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Effects of regular exercise on inflammasome activation-related inflammatory cytokine levels in older adults: a systematic review and meta-analysis
Published in Journal of Sports Sciences, 2021
Yijian Ding, Xi Xu
Ageing is a highly complicated process characterised by progressive impairment of physiological homoeostasis at the molecular, cellular and tissue levels (Lopez-Otin et al., 2013). During ageing, chronic, low-grade inflammation, known as inflammaging, develops (Franceschi et al., 2000). Inflammaging significantly increases the risk of the onset of chronic inflammation-associated diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic disorders and cancer (Ferrucci & Fabbri, 2018; Rea et al., 2018). A better understanding of the mechanisms of inflammaging and looking for effective countermeasures is, therefore, critical to improve health and quality of life in an ageing population.