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Controlling both the constructive power and the destructive power of inflammation to promote repair and regeneration
Published in David M. Gardiner, Regenerative Engineering and Developmental Biology, 2017
In the context of injury/surgery, the resolution of inflammation and return to homeostasis are critical for efficient repair (Eming et al. 2014). Inflammation must be controlled, as persistent (chronic) inflammation leads to a range of neurodegenerative and cardiovascular diseases, autoimmunity, and cancer, along with various metabolic disorders (Medzhitov 2008; Manabe 2011; De Lerma Barbaro et al. 2014; Matsushima 2014; Crupi et al. 2015). It is for these reasons that the deployment of implantable devices or treatments in regenerative medicine must be performed with caution. For the safety of the patient, there must be careful evaluation of the potential for the intervention to elicit low-level persistent inflammation.
Anti-Inflammatory Dendrimers
Published in Delphine Felder-Flesch, Dendrimers in Nanomedicine, 2016
Cédric-Olivier Turrin, Anne-Marie Caminade
Acute inflammation refers to rapid inflammatory, relatively nonspecific, responses that last few days, and originates from infections, tissue necrosis (thermal injury for example), foreign bodies or immune reactions related to hypersensitivity reaction (allergy, autoimmune diseases). In this regard, acute inflammation can be considered as an appropriate host response to infection or injury. Chronic inflammation refers to progressive, relatively specific and often severe inflammatory responses that may last over a long duration. Chronic inflammation may result from persistent injury or infection (ulcer), prolonged exposure to toxic agents or autoimmune diseases.
Terpenoids: The Biological Key Molecules
Published in Dijendra Nath Roy, Terpenoids Against Human Diseases, 2019
Moumita Majumdar, Dijendra Nath Roy
Inflammation is a major role of the immune system. Chronic inflammation can eventually result in the development of several severe diseases, including a few types of cancer, multiple sclerosis, asthma and rheumatoid arthritis. Marine invertebrates are reported to be an extraordinary source of new natural terpenoids. The probable cause of anti-inflammatory signalling of these marine products is inhibition of NF-κB activation, which modulates arachidonic acid metabolism.
Muscular fitness, Southern European Atlantic Diet and inflammation in adolescents. Azorean Physical Activity and Health Study II
Published in European Journal of Sport Science, 2018
César Agostinis-Sobrinho, Caroline Brand, Carla Moreira, Luís Lopes, José Oliveira-santos, Pedro Silva, Anelise Reis Gaya, Adroaldo Gaya, Jorge Mota, Rute Santos, Sandra Abreu
The inflammatory status is influenced by several factors. Inadequate lifestyle behaviours such as physical inactivity and unhealthy diet seem to be the most common factors during childhood and adolescence (Andersen, Riddoch, Kriemler, & Hills, 2011). Diet may play a central role in the regulation of chronic inflammation and endothelial function (Cavicchia et al., 2009). The Southern European Atlantic Diet (SEADiet) is the traditional diet consumed northwest of the Iberian Peninsula-in particular, northern Portugal and Galicia (a region in the northwest of Spain) and consists of a high intake of seasonal legumes, vegetables, potatoes, whole-grain bread (either from corn or wheat), fish, particularly cod, but also red meat, pork, and dairy products (Oliveira, Lopes, & Rodríguez-Artalejo, 2010). The adherence to a SEADiet has been associated with a lower concentrations of CRP (Guallar-Castillón, Oliveira, Lopes, López-García, & Rodríguez-Artalejo, 2013) and inversely associated with the occurrence of non-fatal acute myocardial infarction (Oliveira et al., 2010).
Effects of regular exercise on inflammasome activation-related inflammatory cytokine levels in older adults: a systematic review and meta-analysis
Published in Journal of Sports Sciences, 2021
Ageing is a highly complicated process characterised by progressive impairment of physiological homoeostasis at the molecular, cellular and tissue levels (Lopez-Otin et al., 2013). During ageing, chronic, low-grade inflammation, known as inflammaging, develops (Franceschi et al., 2000). Inflammaging significantly increases the risk of the onset of chronic inflammation-associated diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic disorders and cancer (Ferrucci & Fabbri, 2018; Rea et al., 2018). A better understanding of the mechanisms of inflammaging and looking for effective countermeasures is, therefore, critical to improve health and quality of life in an ageing population.