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Published in Emmanuel Tsekleves, John Keady, Design for People Living with Dementia, 2021
Emmanuel Tsekleves, John Keady
In the mild stage of Alzheimer’s disease, symptoms typically include forgetfulness, losing or misplacing things, difficulty finding the right words and showing poor judgment with planning and decision-making. People with mild Alzheimer’s disease might be unable able to recall a recent conversation or the name of a familiar object, even though it might be on the tip of their tongue.
PSO-Based Optimized Machine Learning Algorithms for the Prediction of Alzheimer’s Disease
Published in Rohit Raja, Sandeep Kumar, Shilpa Rani, K. Ramya Laxmi, Artificial Intelligence and Machine Learning in 2D/3D Medical Image Processing, 2020
Saroj Kumar Pandey, Rekh Ram Janghel, Pankaj Kumar Mishra, Kshitiz Varma, Prashant Kumar, Saurabh Dewangan
Alzheimer’s Disease is a kind of neurodegenerative disease of the central nervous system characterized by progressive cognitive impairment. ‘Sixth main cause of death with a rising ‘population is Alzheimer’s Disease and it is also known as late-life disease. Although there are ‘some medical treatment may temporarily show positive effects but ‘none has demonstrated the capability of preventing deterioration’ [2]. ‘Alzheimer’s Disease (AD) is the most common type of’ disease ‘among people 65 years and older. In this disease the mental ability of persons gradually decreases and reaches a stage where it becomes very difficult for them to live a normal life. It is expected that 1 in 85 people will be affected by 2050 and the number of affected people is going to be doubled in the next 20 years [3].
Defining Older Adult User Groups
Published in Walter R. Boot, Neil Charness, Sara J. Czaja, Wendy A. Rogers, Designing for Older Adults, 2020
Walter R. Boot, Neil Charness, Sara J. Czaja, Wendy A. Rogers
The prevalence of Alzheimer’s disease (AD) is expected to increase significantly in the United States and worldwide in the coming decades, with a related increase in the burden on the patient, family members, and society. AD is a devastating disease that erodes the quality of life and functioning of the individual with AD, generates high levels of stress and burden on family caregivers, and results in substantial economic burdens to society. The majority of people with Alzheimer’s disease are cared for at home by family members or “fictive” family members such as friends or neighbors. Although there are positive aspects of caregiving such as giving back to someone and experiencing personal growth, the negative consequences of caregiving are well documented, especially for caregivers of patients with AD. Caregiving can be extremely stressful and result in negative physical and emotional health consequences for the caregiver, disruptions in social and family relationships, and economic burdens.
Neuroprotective effect of quercetin through targeting key genes involved in aluminum chloride induced Alzheimer’s disease in rats
Published in Egyptian Journal of Basic and Applied Sciences, 2023
Hala A Elreedy, Asmaa M. Elfiky, Asmaa Ahmed Mahmoud, Khadiga S. Ibrahim, Mohamed A Ghazy
The prevalence of dementia worldwide is approximated at up to 36 million and is projected to reach 66 million by 2030 and 115 million by 2050, and also around two-thirds of these patients live in developing countries [1]. Alzheimer’s disease (AD) is the most prevalent form of dementia in older patients, and it is distinguished by a gradual deterioration in cognitive ability, mostly beginning with memory impairment [2]. From a neuropathological point of view, AD is distinguished by the accumulation of extracellular beta-amyloid (A) plaques, the rapid exhibition of intracellular tau pathology, the synaptic connections lack in certain brain regions and severe oxidative stress. Environmental factors are associated with an increased risk of Alzheimer’s disease, including exposure to aluminum [3]. According to epidemiological research and animal studies, Al deposition in the hippocampus induces aberrant-amyloid deposition and neuronal apoptosis by stimulating the amyloid formation and neuroinflammation, leading to hippocampal-dependent learning and impairment of memory ability [4,5].
Machine Learning Model and Cuckoo Search in a modular system to identify Alzheimer’s disease from MRI scan images
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2023
Saravanan Thangavel, Saravanakumar Selvaraj
Although Alzheimer’s Disease (AD) typically affects people over 65, early symptoms of this fatal neurodegenerative disorder can be detected as early as 45. When two uncharacteristic probes in wreckage called brain plague and tangle are deposited, neurons in the brain die. The hippocampus is the primary region of the mental power to be affected by Alzheimer’s Disease. This is where our earliest memories are formed (Saravanakumar and Saravanan 2022). Some of the first signs and symptoms of Alzheimer’s disease are problems with memory, like having trouble finding words or thinking clearly. Patients with AD experience behavioural changes, personality variations, a lack of initiative, and even routine functions at home or work, all of which contribute to their eventual death. As Alzheimer’s disease progresses, the brain’s volume decreases, affecting nearly all functions.
Leung-Malik Features and Adaboost Perform Classification of Alzheimer’s Disease Stages
Published in IETE Journal of Research, 2022
Shaik Basheera, M. Satya Sai Ram
Alzheimer’s disease is now the sixth largest cause of mortality in the United States, according to the most recent health survey. The most common kind of dementia that is associated with ageing is Alzheimer’s disease (AD). The first indication of Alzheimer’s disease is memory loss, which may disrupt a person’s routine. The hippocampus becomes smaller as Alzheimer’s disease progresses, the ventricular system enlarges and produces more cerebral spinal fluid (CSF), the volume of white matter (WM) in the brain decreases, and the volume of grey matter (GM) in the brain reduces. The Apolipoprotein e4 gene in the family and the individual’s own genetic make-up have a role in this (APOE4). AD is a progressive, fatal neurodegenerative disease characterized by the progressive death of brain cells and the loss of their connections to other neurons. The most important step is to get a diagnosis of Alzheimer’s disease at an early stage. The medical history of the patient, a neurological examination, a physical examination, and an assessment of the person’s memory and thinking using a unique questionnaire that was particularly devised by the physicians all contribute to the process of diagnosing Alzheimer’s disease in a patient. In addition to that, they use a rating for dementia and the Mini-Mental State Examination (MMSE). The National Institute on Aging and the Alzheimer’s Association were the first organizations to define clinical criteria for the diagnosis of Alzheimer’s disease. In addition to the clinical methods described above, a variety of imaging modalities are used to arrive at a diagnosis of Alzheimer’s disease stage.