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Marine Polysaccharides from Algae
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Wen-Yu Lu, Hui-Jing Li, Yan-Chao Wu
Neurodegenerative diseases are progressive damage of neurons, which are mainly related to the death of neurons. This leads to a gradual loss of cognitive and physical function. The most common neurodegenerative diseases are Huntington’s disease, Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) (Lin and Beal, 2006). There are two main types of neurodegenerative diseases: dyskinesia and degeneration/dementia disorders (Huang et al., 2018). The disease afflicts about 35.6 million people around the world. The number is expected to double by 2030 and triple by 2050. Even in most high-income countries, it is difficult for dementia patients to obtain adequate medical care, where only about 50% of dementia patients are correctly diagnosed, while in low-income and middle-income countries, less than 10% of cases are diagnosed. With the aging of the population, the number of patients with dementia is also increasing (Jager et al., 2014).
Age-Related Physiological Changes Influencing Work Ability
Published in Joanna Bugajska, Teresa Makowiec-Dąbrowska, Tomasz Kostka, Individual and Occupational Determinants, 2020
Due to their increasing occurrence with age, several debilitating neurological and psychiatric disorders contribute to further deterioration of neuropsychological functioning. Stroke is one of the leading causes of disability in older people (Kostka et al. 2019). About 30% of people who survive a stroke become disabled and require assistance. Other important neurodegenerative disorders include Alzheimer’s disease and different types of dementia, Parkinson’s disease, depression and delirium.
Nanotechnological Interventions for Neurodegenerative Disorders Using Phytoactives
Published in Bhupinder Singh, Om Prakash Katare, Eliana B. Souto, NanoAgroceuticals & NanoPhytoChemicals, 2018
Sumant Saini, Charan Singh, Shikha Lohan, Atul Jain, Eliana B. Souto, Bhupinder Singh
Considering the multimodal applicability of such engineered nanoscaled systems, these have also been explored in the management of various neurodegenerative disorders. The merit associated with these nanostructured systems is that they can easily move across the hitherto impermeable BBB and can effectively act at the target site in a precise manner, resulting eventually in improved access and modulatory potential of the bioactives.
The relationship between activity level and cognitive function in Chinese community-dwelling elderly
Published in Research in Sports Medicine, 2022
Man-Li Liu, Li-Jun Jiang, Wen-Xiao Wang, Xiao Zhang, Xiao-Hua Xing, Wei Deng, Tao Li
As of the end of 2019, China’s elderly aged 60 years or above accounted for 18.1% of the whole population. Cognitive function deteriorates as people age and the incidence of all-cause dementia nearly doubles with every 5 years of age. Since with the changes in population structure and the increase longer of life expectancy, the prevalence of cognitive impairment and dementia in the elderly population is expected to increase significantly in the future (Moore, 2007). However, no matter age-related cognition decline, mild cognitive impairment (MCI) or dementia has indeed challenged our society. With 10 million dementia people in China, a conservative estimate of monetary costs of dementia was about US$70 billion (Xu et al., 2017), and the costs will increase dramatically over the coming decades (Jia et al., 2018). However, effective curative medicines are still not available for these neurodegenerative disease(Winblad et al., 2016). It is important to explore non-pharmacological interventions to prevent cognitive disorders in old age.
Enhanced bone marrow stem cell attachment and differentiation on PCL/CNT substrate
Published in Inorganic and Nano-Metal Chemistry, 2019
Maryam Mehdizadeh Omrani, Mojtaba Ansari, Soheila Salahshour Kordestani, Nasim Kiaie, Amir Salati
Today, many people suffer from neurodegenerative diseases such as Alzheimer, Huntington, Parkinson and other injuries. These diseases affect different areas of the brain and have common characteristics. In all of them, neurons lose their connections with the surrounding nerve cells and electrical signals which are responsible for cell activity are unable to be transmitted and neurons will die. The human body can compensate this damage to some extent through neural stem cells in the brain. Currently, there is no cure for these diseases. Available treatment methods only slow down the disease process but do not stop it. Therefore, scientists are trying to develop existing treatment methods into cell therapy and tissue engineering.[1–4]
A Comparative Study of Existing Machine Learning Approaches for Parkinson's Disease Detection
Published in IETE Journal of Research, 2021
Gunjan Pahuja, T. N. Nagabhushan
Parkinson's disease (PD) is a progressive neurodegenerative disorder of the nervous system that affects our body movements including speech. Dr. James Parkinson in 1817 [1] discovered this disease and described the condition which he called the ‘Shaking Palsy’. Neurodegenerative diseases are defined as hereditary and sporadic conditions which are characterized by dysfunction of the progressive nervous system (JPND research, 2015). Out of many neurodegenerative diseases like Alzheimer's disease, Brain Cancer, Degenerative Nerve Diseases and Epilepsy, “Parkinson's Disease” is considered to be the second most common neurodegenerative disease [2].