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Stem Cell Banking for Regenerative and Personalized Medicine
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2020
Cord blood is unique in that it contains hematologic stem cells and thus may be used to reconstitute the blood and immune system after chemotherapy, radiation and stem cell transplant. Although bone marrow is similar in this regard, neither cord tissue nor adipose tissue has this capability. Cord blood may be used to treat more than 80 malignant and non-malignant hematologic conditions requiring transplant. In addition, CB may also be used for regenerative medicine and tissue engineering applications, as can cord tissue and adipose tissue MSC [14, 21]. In the transplant setting CT-MSCs have shown positive results in the treatment of GVHD following hematopoietic stem cell transplantation. Wu et al. [73] found that CT-MSC had superior proliferative potential and increased immunosuppressive effects as compared to bone marrow MSC. Two pediatric patients with severe steroid-resistant GVHD were infused with ex vivo expanded CT MSCs. The GVHD improved dramatically in both patients following infusion of CT-MSCs, although one patient needed to receive multiple infusions of MSCs over the course of treatment [73]. CT-MSCs have also been evaluated for potential therapeutic benefits in autoimmune diseases. Liang et al. [74] reported that CT-MSCs stabilized the disease course of a patient with progressive multiple sclerosis that was not responsive to conventional treatment [74]. A subsequent study from the same group reported dramatic improvements in a patient with systemic lupus erythematosus following intravenous infusion of CT-MSCs [75]. Importantly none of the case reports indicated adverse effects associated with infusion of CT-MSCs.
Stem Cell Banking for Regenerative and Personalized Medicine
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2019
Cord blood is unique in that it contains hematologic stem cells and thus may be used to reconstitute the blood and immune system after chemotherapy, radiation and stem cell transplant. Although bone marrow is similar in this regard, neither cord tissue nor adipose tissue has this capability. Cord blood may be used to treat more than 80 malignant and non-malignant hematologic conditions requiring transplant. In addition, CB may also be used for regenerative medicine and tissue engineering applications, as can cord tissue and adipose tissue MSC [14, 21]. In the transplant setting CT-MSCs have shown positive results in the treatment of GVHD following hematopoietic stem cell transplantation. Wu et al. [73] found that CT-MSC had superior proliferative potential and increased immunosuppressive effects as compared to bone marrow MSC. Two pediatric patients with severe steroid-resistant GVHD were infused with ex vivo expanded CT MSCs. The GVHD improved dramatically in both patients following infusion of CT-MSCs, although one patient needed to receive multiple infusions of MSCs over the course of treatment [73]. CT-MSCs have also been evaluated for potential therapeutic benefits in autoimmune diseases. Liang et al. [74] reported that CT-MSCs stabilized the disease course of a patient with progressive multiple sclerosis that was not responsive to conventional treatment [74]. A subsequent study from the same group reported dramatic improvements in a patient with systemic lupus erythematosus following intravenous infusion of CT-MSCs [75]. Importantly none of the case reports indicated adverse effects associated with infusion of CT-MSCs.
Glossary of scientific and technical terms in bioengineering and biological engineering
Published in Megh R. Goyal, Scientific and Technical Terms in Bioengineering and Biological Engineering, 2018
Placental cord (umbilical cord) is the structure connecting the embryo/fetus to the placenta. It is initially extra-embryonic mesoderm forming the connecting stalk within which the placental blood vessels (arteries and veins) form. In human placental cords the placental blood vessels are initially paired, later in development only a single placental vein remains with a pair of placental arteries. This structure also contains the allantois, an extension from the hindgut cloaca then urogenital sinus. Blood collected from the placental cord following delivery is a source of cord blood stem cells.)
Application of a novel mass spectrometric (MS) method to examine exposure to Bisphenol-A and common substitutes in a maternal fetal cohort
Published in Human and Ecological Risk Assessment: An International Journal, 2018
Erin Speiser Ihde, Stacy Zamudio, Ji Meng Loh, Yalin Zhu, John Woytanowski, Lawrence Rosen, Min Liu, Brian Buckley
To achieve a total of 30 evaluable samples, 35 patients were consented and enrolled. Five were omitted prior to analysis due to complications with collecting samples or failure to meet all study inclusion criteria (below). The samples were acquired at Caesarean section deliveries at Hackensack University Medical Center, Hackensack, New Jersey. Treatment of patients was not under investigation in this research study. Cord blood samples were collected from otherwise discarded umbilical cords/cord blood samples taken for routine newborn testing.