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Gastroretentive Drug Delivery Systems
Published in Ambikanandan Misra, Aliasgar Shahiwala, In-Vitro and In-Vivo Tools in Drug Delivery Research for Optimum Clinical Outcomes, 2018
Bhupinder Singh, Hetal P. Thakkar, Sanjay Bansal, Sumant Saini, Meena Bansal, Praveen K. Srivastava
Bioadhesive or mucoadhesive DDS utilize the bioadhesive properties of certain water-soluble polymers that become adhesive on hydration and can adhere to the epithelial surface in the stomach. Hence, this can be used for targeting a drug to a particular region of the body. Some of the promising bioadhesives commonly used include polycarbophil, carbopol, chitosan, and carboxymethylcellulose. Gastric mucoadhesion alone does not tend to be strong enough to impart to dosage forms the ability to resist the strong propulsion forces of the stomach wall. The continuous production of mucous by the gastric mucosa to replace the mucous that is lost through peristaltic contractions and the dilution of the stomach content also seems to limit the potential of mucoadhesion as a GR force (Thombre and Gide 2016).
Hydrophilic Adhesives
Published in István Benedek, Mikhail M. Feldstein, Technology of Pressure-Sensitive Adhesives and Products, 2008
Mikhail M. Feldstein, Parminder Singh, Gary W. Cleary
Bioadhesion is a special case of adhesion in which the substrate is skin or a mucous membrane. Bioadhesion (and mucoadhesion) is the process whereby synthetic and natural macromolecules adhere to the skin or mucosal surfaces in the body.10 A primary process in bioadhesion, as well as in adhesion, is a series of physicochemical interactions between functional groups of bioadhesive material and the substrate,71,72 followed by the diffusion of bioadhesive molecules into the biosubstrate.73 Bioadhesives are now gaining increasing attention because these polymers bind directly to receptors on the cell surface rather than to the mucus gel layer.74 Because specific binding to the cell surface is often followed by uptake and intracellular transport, new opportunities for drug delivery are evolving.75 Bioadhesion may, thus, enable researchers to deliver macromolecular drugs directly to specific target cells and has implications that are relevant to other fields of science, such as tissue engineering, gene delivery, and nanotechnology.76 However, in this section we mainly focus on adhesion to skin, buccal membranes, and dental tissue, because it is precisely these areas of applications that require materials with performance properties similar to the behavior of PSAs.
Bioadhesive Drug Delivery Systems
Published in Severian Dumitriu, Valentin Popa, Polymeric Biomaterials, 2020
Ryan F. Donnelly, A. David Woolfson
There has been an increasing interest in the use of bioadhesive polymers in the design of drug delivery systems. One of the advantages of using these materials is that they can maintain contact with mucosal surfaces for much longer periods of time than non-bioadhesive polymers. Since polymers possessing bioadhesive properties can retain drugs in close proximity to membranes rich in underlying vasculature, they may offer a solution to the poor bioavailability of some drugs and a method to avoid enzymatic degradation of others.
A Novel High-strength Autologous Fibrin Glue Augmented with Biocompatible Polymers
Published in The Journal of Adhesion, 2023
Anindya Karmaker, Mahmudul Hasan, Shafayet Ali, Kazi Md Asif, Shoeb Ahmed
The formation of a fibrin clot is the body’s natural way to halt the bleeding and speed up the healing process. This natural healing mechanism has motivated the creation and development of several types of bioadhesives. The three most frequent forms of bioadhesives utilized in surgical applications are hemostatic agents, tissue adhesives, and sealants.[4] Even though the three adhesive kinds have distinct names, they work similarly and are classified based on the application stage and purpose. Hemostatic drugs improve primary hemostasis, induce fibrin production and prevent fibrinolysis.[5] In the event of a surgery, a major injury, or bleeding management, hemostatic agents, or simply hemostats, may be required to control blood loss.[6] Because of their viscose and paste-like flowable matrix, some commercially available hemostats may be injected directly into the wound region,[4].[7] Tissue adhesives are a class of natural and synthetic substances that are currently employed in a variety of local applications for hemostasis, wound closure, and fistula healing. The most often used tissue adhesives include cyanoacrylates, fibrin glues, and thrombin.[8] Through polymerization or crosslinking reaction, tissue adhesives form an insoluble matrix in the wound.[9] A sealant is a substance that is used to prevent fluids from passing through a surface, joints, or gaps in materials.[4] Most tissue adhesives and hemostats can act as sealants.
Fifty years of the Journal of Adhesion
Published in The Journal of Adhesion, 2019
S. de Barros, R. G. Barbastefano, C. G. de Souza, L. F. M. da Silva, L. Sharpe
If the trend seen the last 50 years are extrapolated for the next 50 years, the adhesion community have reasons to be optimistic and important advances can be foreseen such as smart adhesives with multiple functions such as graded properties as a function of the stress distribution, self-healing properties, poor adhesion detection or dismantling capacity. One of the main challenges is to formulate a bioadhesive that is as strong and durable as a synthetic adhesive. But the holy grail of adhesion technology is to find a suitable non-destructive technique to detect poor adhesion. The adhesion community has used JA to disseminate the most recent advances in adhesion and adhesives for 50 years. This editorial is to celebrate 50 years of exitance of JA and thank all the authors that contributed to this wealth of knowledge.