SPARCL1

SPARCL1

The Induction of Bone Formation and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family

Published in Ugo Ripamonti, The Geometric Induction of Bone Formation, 2020

There is of course no direct correlation between being massively predated and the evolutionary appearances of the vertebrates’ bony armour and later of the skeleton. Rather, positive gene mutations selectively at that point in time set into motion different calcium homeostasis profiles (Venkatesh et al. 2014) with later the appearance of the osteogenic proteins of the TGF-β supergene family (Ripamonti 2003). The development and appearance of specific secretory calcium binding phosphoproteins (SCPPs), arising from the Sparc-like1 gene (Sparcl1), would have been critical for the evolutionary beginning of bone formation (Venkatesh et al. 2014).

SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension

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Journal Information

Published in Biomarkers, 2020

Stanislav Keranov, Oliver Dörr, Leili Jafari, Christoph Liebetrau, Till Keller, Christian Troidl, Steffen Kriechbaum, Sandra Voss, Manuel Richter, Khodr Tello, Henning Gall, Hossein A. Ghofrani, Eckhard Mayer, Werner Seeger, Christian W. Hamm, Holger Nef

SPARCL1 (also known as Hevin and SC1) is a secreted glycoprotein that is part of the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins (Sullivan et al.2006). Existing evidence shows that SPARCL1 may be associated with pathological remodelling in the settings of chronic pressure overload (St Croix et al.2000, Imoto et al.2017). Therefore, we aimed to determine the potential of SPARCL1 as a plasma biomarker of pathological myocardial remodelling and RV maladaptation in PH.

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The Induction of Bone Formation and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family

SPARCL1 as a biomarker of maladaptive right ventricular remodelling in pulmonary hypertension