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The melanocyte and melaninogenesis
Published in Dimitris Rigopoulos, Alexander C. Katoulis, Hyperpigmentation, 2017
Dimitrios Xekardakis, Sabine Krueger-Krasagakis, Konstantinos Krasagakis
Many common drugs have an effect on melaninogenesis. The most known are antiepileptic agents (hydantoins), antibiotics (such as tetracyclines), diuretics, chloroquine, levodopa, nonsteroidal anti-inflammatory drugs, oral contraceptives, some chemotherapy agents (doxorubicin, cyclophosphamide, and others), and heavy metals.6 (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol (DMPB), which is a component of a tropical ginger of Southeast Asia named Zingiber cassumunar Roxb, seems to trigger tyrosinase expression and activity, to increase dendrite formation, and finally, to increase melanin synthesis in human melanocytes.39
Lipogenesis inhibition and adipogenesis regulation via PPARγ pathway in 3T3-L1 cells by Zingiber cassumunar Roxb. rhizome extracts
Published in Egyptian Journal of Basic and Applied Sciences, 2018
Natthawut Wong-a-nan, Kewalin Inthanon, Aroonchai Saiai, Angkhana Inta, Wutigri Nimlamool, Siriwadee Chomdej, Prasat Kittakoop, Weerah Wongkham
The rhizome, young leaves and flowers of Zingiber cassumunar Roxb. (ZC) (Zingiberaceae) have long been used as a flavorings in Thai cuisine and as fresh ingredients in northern Thai salads. Synonyms of the scientific name include Zingiber montanum (J. Koenig) Link ex A. Dietr. (ZM) and Z. purpureum Roscoe. [1]. The Thai name of this monocotyledonous plant is Phlai or Plai [2,3] and the international common name is cassumunar ginger [4]. ZC has been investigated for several pharmacological properties, including antioxidant [5], anti-inflammation [6], anti-allergic [7], anti-proliferative [8], antiulcer [9] and insecticidal [10]. Anti-adipogenic activity of closely related species has been mentioned in several publications (e.g. Z. officinale Roscoe (ginger) [11,12] , Z. zerumbet Smith (bitter ginger) [13] and Z. mioga Roscoe (mioga ginger) [14]), while for ZC only one reports have been published on the in vitro inhibitory effect on pancreatic lipase activity [15]. In northern Thailand, ZC is an ingredient in several pharmacological remedies to treat obesity among tribal people [16]. Consequently, this study investigated the potential and cellular mechanism of anti-adipogenic and lipolytic activity of crude extracts from ZC rhizomes on an in vitro culture system using the mouse adipocyte cell-model, 3T3-L1.
Curcumin and neurological diseases
Published in Nutritional Neuroscience, 2022
Raffaella Adami, Daniele Bottai
Cur is a phytopolylphenol pigment, (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione, which obtained from the plant Curcuma longa (but also found in Curcuma aromatica, mangga, phaeocaulis, xanthorrhiza, zedoaria, Etlingera elatior, Zingiber cassumunar and Costus speciosus); it is commonly known as turmeric. Turmeric is a perennial herbaceous plant with oblong, palmate roots and tubers; it grows spontaneously in southern Asia and Africa in tropical climate regions with high rainfall and a normal temperature range between 20 and 35 °C [2].