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Environmental Factors Impacting Bioactive Metabolite Accumulation in Brazilian Medicinal Plants
Published in Luzia Valentina Modolo, Mary Ann Foglio, Brazilian Medicinal Plants, 2019
Camila Fernanda de Oliveira Junkes, Franciele Antonia Neis, Fernanda de Costa, Anna Carolina Alves Yendo, Arthur Germano Fett-Neto
Cordia verbenacea DC. is a native Brazilian medicinal plant, widely distributed along the Southeast coast of Brazil. This bushy plant is popularly known as cordia, blacksage or erva baleeira and has been known for its properties as antiulcer, antimicrobial and anti-inflammatory (Falcão et al., 2008; Michielin et al., 2009). Several compounds are found in the aerial parts of C. verbenacea including α-pinene, trans-caryophyllene, aloaromadendrene, cordialin A, cordialin B, rosmarinic acid and flavanols (Thirupathi et al., 2008). The phenolic rosmarinic acid is regarded as a phytochemical marker of C. verbenaceae due to its abundance in the species. A relatively strong positive correlation between the rainy season at a Central Brazil locality and rosmarinic acid content was reported, suggesting the wet period is the best choice for harvesting this medicinal plant (Matos et al., 2015). According to Queiroz et al. (2016), the harvest time during the day did not influence the content of essential oil, but it could modify its chemical profile. Even though the concentrations of the major compounds β-caryophyllene, xylene and γ-muurolene displayed no differences among collection times, sabinene was found only during early morning (6 am) harvest.
Sabinene suppresses growth, biofilm formation, and adhesion of Streptococcus mutans by inhibiting cariogenic virulence factors
Published in Journal of Oral Microbiology, 2019
Bog-Im Park, Beom-Su Kim, Kang-Ju Kim, Yong-Ouk You
Sabinene is a chemical compound found in herbal essential oils, including the oil extracted from Chamaecyparis obtusa. C. obtusa belongs to the species cypress that is used in construction and furniture industries because of its structural properties and natural aroma. Its essential oil has been widely used as functional additives in several industries, including cosmetics. The essential oil extracted from C. obtusa contains several types of terpenes, including limonene, bornyl acetate, and borneol, and exhibits biological properties such as antioxidant and anti-inflammatory effects [7,8]. Sabinene is a natural liquid monoterpene obtained from essential oils of various plants, including Cannabis. The chemical formula of sabinene is C10H6 and it has a bicyclic structure [9]. Several studies have reported the biological functions of sabinene, including its antifungal [10] and anti-inflammatory properties [11]. However, the effects of sabinene on the cariogenic activity of S. mutans have been incompletely characterized.