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Plant Source Foods
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Galangal contains several important chemical compounds that give it its different medicinal properties. In total, 544 compounds were isolated from 35 Alpinia species (218). Different compounds in galangal are: 210 terpenoids, 143 diarylheptanoids, 71 flavonoids, 66 phenolics (including 2 abundant phenol derivatives named acetoxychavicol acetate and acetoxyeugenol acetate), 24 lignans, 6 stilbenes, 4 steroids, 3 fatty acids, 2 alkaloids, 2 glycosides, 1 ester, and some vitamins and minerals (215–222). Previous phytochemical investigations have shown that both A. galanga and A. officinarum have some similar chemical constituents, such as diarylheptanoids, flavonoids, volatile oil, terpenes, phenylpropanoids, and glycosides, though the main chemical components are different. A. galanga is rich in a variety of phenolic compounds and essential oils, whereas A. officinarum is rich in flavonoids and diarylheptanoids (222). Investigations have shown A. galanga and A. officinarum to have many biological activities, including effectiveness as anti-inflammatory, antiviral, antimicrobial, antioxidant, antitumor, anti-allergic, and gastro-protective agents (222).
Pullulan based derivatives: synthesis, enhanced physicochemical properties, and applications
Published in Drug Delivery, 2022
Surendra Agrawal, Divya Budhwani, Pravina Gurjar, Darshan Telange, Vijay Lambole
An edible film was prepared using carboxymethyl chitosan-pullulan for preserving mangoes. The film resulted in the prolonged shelf life of mangoes. In addition, Galangal essential oil (GEO) was added to get antimicrobial action. GEO has antioxidant properties along with antitumor, anti-inflammatory, and anticoagulation action. Carboxymethyl chitosan-pullulan is a promising food packaging agent to prolong the shelf life of fresh and processed products (Zhou et al., 2021). An injectable hydrogel of amoxicillin was obtained by grafting poloxamer 407 in CMP. The hydrogel showed great elasticity and excellent ability to recover the initial structure after the removal of applied stress. Poloxamer 407 is a thermosensitive copolymer. This combination showed sustained release of amoxicillin, which indicates the success of CMP-poloxamer copolymer for the formulation of injectable hydrogels (Constantin et al., 2021).
Protective effects of total flavonoids from Alpinia officinarum rhizoma against ethanol-induced gastric ulcer in vivo and in vitro
Published in Pharmaceutical Biology, 2020
Kaiwen Lin, Yong Wang, Jingwen Gong, Yinfeng Tan, Tang Deng, Na Wei
The results showed that F-AOH had anti-inflammatory and protective effects on ethanol-induced gastric ulcer. The underlying mechanism may be related to the abnormally increased negative feedback regulation of NO, the activation of NF-κB/COX-2 signalling pathway, and the influence of downstream inflammatory factor levels. These findings provide a basis for the clinical treatment of gastric ulcer with the Chinese herbal medicine galangal, demonstrating the pharmacological activity and anti-inflammatory effect of F-AOH, which can be used as a potential gastroprotective agent. Furthermore, with regard to the anti-inflammatory and protective effects of F-AOH on gastric ulcers, further studies are required to determine the exact mechanism of the feedback effect of NO on the biphasic regulation between the NF-κB/COX-2 and downstream signalling pathways.
Green synthesis of silver nanoparticles from Alpinia officinarum mitigates cisplatin-induced nephrotoxicity via down-regulating apoptotic pathway in rats
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Zhiping Zhang, Guangda Xin, Guangyu Zhou, Qianyu Li, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Dayu Wang, Feng Liu
Plants are the major natural reservoir of antioxidants and they are used to treat various diseases like cancer, inflammation, hepatic disorders, kidney disorders etc., Alpinia officinarum, lesser galangal is a traditional plant of India and China [15]. It is a perennial herb belonging to the ginger family Zingiberaceae possessing ornamental leaves and white flowers [16]. Rhizome of A. officinarum possesses immense pharmacological traits like antitumor, antiulcer, antibacterial, and antifungal properties [17–19]. Poor bioavailability was the foremost drawback of herbal-based drugs. Nanoparticles are a promising agent to overcome the poor bioavailability of herbal-based drugs. Compared to physical and chemical synthesized nanoparticles green synthesized nanoparticles are more potent, eco-friendly, economic and without any side effects [20,21]. Phytochemicals present in plants reduces the metals and stabilizes the ions to form nanoparticles [22]. Various studies are reported the medicinal potency of silver nanoparticles synthesized from plant extracts against cancer, bacterial infection, inflammation. etc [23–25].