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Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Synonyms: Boesenbergia rotunda (L.) Mansf.; Kaempferia pandurata Roxb.Common name: ao chun jiang (Chinese)Subclass Commelinidae, Superorder Zingiberanae, Order Zingiberales, Family ZingiberaceaeMedicinal use: indigestion (China)Pharmacological target: atherogenic hyperlipidemia
Factors determining phage stability/activity: challenges in practical phage application
Published in Expert Review of Anti-infective Therapy, 2019
Ewa Jończyk-Matysiak, Norbert Łodej, Dominika Kula, Barbara Owczarek, Filip Orwat, Ryszard Międzybrodzki, Joanna Neuberg, Natalia Bagińska, Beata Weber-Dąbrowska, Andrzej Górski
Pimchan et al. (2018) investigated the in vitro activity of plant extracts (obtained from Stephania suberosa and Oroxylum indicum – used in traditional Asian medicine) combined with lytic SU27 phage application against E. coli and extracts’ impact on phage activity [206]. They observed that in the case of phage alone and phage with pulp plant extract the bacterial titer was significantly reduced after 6 h when compared to the untreated control or bacteria treated with extracts only. In the case of samples treated with SU27 and extracts of Boesenbergia rotunda (after 4 h) and Oroxylum indicum (after 8 h) an additive effect was observed, but after 2 and 8 h of incubation Oroxylum indicum at a concentration of 16 mg ml−1 significantly reduced phage titer. This research shows the possibility to use a combined therapy using both phages and plant extracts which may be effective in antimicrobial activity. Also research conducted by Ghosh et al. (2015) indicated potential phage K combined with essential oil compounds (alpha-pinene, 3-carene, +limonene, (1S)-(-)-b-pinene) to control S. aureus [207]. Unfortunately, detailed results showing essential oils’ interference with phage particles and their impact on phage activity have not been published. Chantril et al. (1952) observed that 8 of 288 tested extracts obtained from British plants suppressed the activity of Pseudomonas pyocyanea phage at concentrations of less than one-tenth of those that affected the growth of bacteria [208]. Moreover, two extracts (from Epilobium angustifolium L. and from Saxifraga ligulata), and their concentrates inactivated the phages of P. pyocyanea and T5 active against E. coli during 30 min incubation at room temperature, but they did not do so in the presence of broth.
Cytotoxic Activity of Boesenbergia rotunda Extracts against Nasopharyngeal Carcinoma Cells (HK1). Cardamonin, a Boesenbergia rotunda Constituent, Inhibits Growth and Migration of HK1 Cells by Inducing Caspase-Dependent Apoptosis and G2/M–Phase Arrest
Published in Nutrition and Cancer, 2021
Mohammed Khaled Bin Break, Michelle Chiang, Christophe Wiart, Chiew-Foan Chin, Alan Soo Beng Khoo, Teng-Jin Khoo
Natural products have always been a rich source of anticancer drugs and several plant-derived molecules have been found to possess cytotoxic activity (2). Boesenbergia rotunda (L.) Mansf. is an edible ginger species that belongs to the Zingiberaceae family and grows in Southeast Asia, India, Sri Lanka and China. It is a common ingredient in the cuisine of several Asian countries such as Malaysia, China and India, whereby it is often added to food, such as curry, in order to enhance the flavor and promote appetite (3).
Absolute oral bioavailability and possible metabolic pathway of panduratin A from Boesenbergia rotunda extract in beagle dogs
Published in Pharmaceutical Biology, 2023
Tussapon Boonyarattanasoonthorn, Teetat Kongratanapasert, Apisada Jiso, Pinnakarn Techapichetvanich, Nitra Nuengchamnong, Kittitach Supannapan, Anusak Kijtawornrat, Phisit Khemawoot
Natural products are known to be the oldest source of drug discovery. Since the outbreak of COVID-19, there has been a dramatic increase in the use of medicinal plants and natural products for prevention and treatment (Boozari and Hosseinzadeh 2021). Thai medicinal plants and their components are promising sources of anti-SARS-CoV-2 agents. Andrographis paniculata (Burm.f.) Wall. ex Nees (Acanthaceae) is a Thai herb approved by the WHO for prophylaxis and symptomatic treatment of upper respiratory infections and acute diarrhea (World Health Organization [WHO] 2002). A. paniculata extract and andrographolide (its major compound) significantly inhibited SARS-CoV-2-infected Calu-3 cells, with an IC50 of 0.036 μg/mL and 0.034 μΜ, respectively (Sa-ngiamsuntorn et al. 2021), and the Royal Thai Government Gazette announced the use of A. paniculata capsules to treat asymptomatic COVID-19 patients in Thailand on 4 June 2021 (NDSDC 2021). In our previous study, 122 extracts and compounds from Thai medicinal plants were screened for antiviral activity against SARS-CoV-2-infected Vero E6 cells. Boesenbergia rotunda (L.) Mansf. (Zingiberaceae), also known as fingerroot extract, and its bioactive compound, panduratin A, exhibited anti-SARS-CoV-2 activity, with IC50 of 3.62 μg/mL and 0.81 μΜ, respectively, whereas the standard drug remdesivir showed an IC50 of 2.71 μΜ (Kanjanasirirat et al. 2020). In our preliminary study, administering fingerroot extract containing panduratin A 15–50 mg/kg/d for 7 d could reduce lung pathology in SARS-CoV-2 infected hamsters. According to interspecies scaling calculation (USFDA 2005), the appropriate dosing of panduratin A in dogs should be 5–10 mg/kg/d. Therefore, an oral formulation of fingerroot extract containing panduratin A 5–10 mg/kg/d was chosen to determine the systemic exposure, possible metabolic pathways, and the excretion route in beagle dogs. Because of the good antiviral activity of B. rotunda extract and panduratin A, this herb may be a possible candidate for COVID-19 drug development. Determining the efficacy, safety, toxicity and pharmacokinetic profiles of panduratin A from fingerroot extract in animal studies is crucial for further product development during this pandemic.