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The Integrative Coronary Heart Disease (CHD) Prevention Program
Published in Mark C Houston, The Truth About Heart Disease, 2023
Turmeric is a spice that has received much interest from both the medical and scientific worlds as well as from the culinary world. It is a rhizomatous herbaceous perennial plant (Curcuma longa) of the ginger family. The medicinal properties of turmeric, the source of curcumin, have been known for thousands of years. It has antioxidant, anti-inflammatory, antimicrobial, and anticancer properties.
Role of Curcuma longa and Its Constituents, Especially Curcumin, in Prevention and Management of Diseases
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
The remarkable effects of turmeric and its constituents are usually acquired by means of its consumption with food, even in minimum quantities for prolonged durations. In TCM, Curcuma longa is recognised as a liver and blood tonic; moreover, it helps to move ‘chi' (qi) and alleviate pain in the body, specifically in the joints. Turmeric also aids in alleviating the inflammation, pain and soreness of muscles after exercise, hence increasing recovery and performance in dynamic people. Numerous phytochemical analyses have demonstrated remarkable constituents in turmeric along with strong therapeutic potential. Certain information about its safety, interactions, mechanism of action and efficient dose is required for the logical use of Curcuma longa and its constituents in the management of various diseases in humans.
Kidney Failure/Renal Insufficiency/Chronic Kidney Disease (CKD)
Published in Charles Theisler, Adjuvant Medical Care, 2023
Turmeric: Clinical studies show that in more than 95% of kidney failure cases, kidney damage is caused by inflammation. Turmeric contains lots of curcumin which can help to block inflammation and thus stop progression of the illness or condition. Previous clinical studies also demonstrate that taking turmeric by mouth (1-3 gm) three times daily for eight weeks reduces itching in people with long-term kidney disease.13
The potential of curcumin for treating spinal cord injury: a meta-analysis study
Published in Nutritional Neuroscience, 2023
Mahnaz Kahuripour, Zahra Behroozi, Behnaz Rahimi, Michael R. Hamblin, Fatemeh Ramezani
Nathan Seddon and colleagues studied the effects of curcumin on cognitive function in 2019 and showed that curcumin improved visual memory and attention [11]. In 2021, Saffarpour and colleagues showed nano-formulated curcumin treatment ameliorates pain-related behaviour and improves spatial memory [12]. In 2016, Daily and colleagues showed the effects of turmeric and curcumin in reducing the symptoms of osteoarthritis in a systematic review and meta-analysis [13]. They showed that the consumption of turmeric extract (about 1000 mg per day) significantly improved osteoarthritis, but the small number of RCTs in the analysis, the total sample size, and the methodological quality were insufficient for definitive conclusions. The study by Sharifiaghdam and colleagues in 2022 showed that nano-formulated curcumin could attenuate doxorubicin-induced cardiotoxicity by regulating apoptosis in a mouse model [14].
Antiinflammatory Activities of Curcumin and Spirulina: Focus on Their Role against COVID-19
Published in Journal of Dietary Supplements, 2023
Angelica Perna, Eleonora Hay, Carmine Sellitto, Emiliano Del Genio, Maria De Falco, Germano Guerra, Antonio De Luca, Paolo De Blasiis, Angela Lucariello
Turmeric is an Indian spice, derived from the rhizome of the Curcuma Longa plant, whose active ingredient, responsible not only for the bright yellow color of this spice but also for its main characteristics, is curcumin. Over the years, studies on turmeric have revealed its beneficial effects in various diseases (Hay et al. 2019), as well as its antioxidant (xxxx n.d), anti inflammatory (Peng et al., 2021) and anticancer properties (Perna et al. 2018). An antiviral activity of curcumin has been demonstrated against several different viruses (Rattis et al. 2021), such as hepatitis viruses (Chen et al. 2012; Colpitts et al. 2014), influenza viruses (Chen et al. 2010; xxxx n.d) and emerging arboviruses like the Zika virus (ZIKV) or chikungunya virus (CHIKV) (Mounce et al. 2017). Interestingly, it has also been shown to reduce the spread of sexually transmitted diseases as it inhibits human immunodeficiency virus (HIV), herpes simplex virus 2 (HSV-2) and human papillomavirus (HPV) (Praditya et al. 2019).
Complexity of Tumor Microenvironment: Therapeutic Role of Curcumin and Its Metabolites
Published in Nutrition and Cancer, 2022
Sahdeo Prasad, Priyanka Saha, Bilash Chatterjee, Anis Ahmad Chaudhary, Rajiv Lall, Amit K Srivastava
Turmeric has been used in diet as spice for centuries, but it also has many medicinal properties. Accumulated evidence has revealed that turmeric and its bioactive constituent, curcumin, exhibit a variety of biological properties including antioxidant, anti-microbial, anti-inflammatory, antiviral, anticancer, anti-allergic, and cholesterol lowering, antidiabetic, cardioprotective, hepatoprotective, and neuroprotective effects (8). Curcumin quenches free radicals and exerts as an antioxidant in normal cells but acts as a prooxidant in cancer cells, and thus acts as a chemopreventive and therapeutic agent (10). Recently, curcumin alone or in combination with other phytomedicine attributed efficacy against the SARS-Cov-2 virus (11). Curcumin exhibits antioxidant activity by quenching free radicals and inducing antioxidant enzymes. It suppresses inflammatory transcription factors STAT3, NF-κB, cytokines, chemokines, and other inflammatory mediators. It has shown to have preventive and therapeutic efficacy against a variety of cancer through inhibition of cancer cell proliferation, angiogenesis, invasion, and metastasis by targeting various kinases, and oncogenes. Curcumin also exerts anticarcinogenic effects by increasing the level of tumor-suppressive protein p53, pro-apoptotic Bax and cytochrome C levels. Moreover, the therapeutic ability of curcumin was further found by initiating apoptosis through the cleavage of apoptotic protein poly (ADP-ribose) polymerase (PARP) (12).