China
Africa
Explore chapters and articles related to this topic
Postmenopause
Published in Carolyn Torkelson, Catherine Marienau, Beyond Menopause, 2023
Carolyn Torkelson, Catherine Marienau
Curcumin is the main active ingredient in turmeric, naturally found in the root of the turmeric plant, which is an herbaceous perennial of the ginger family. Curcumin has antioxidant and anti-inflammatory effects that provide multiple health benefits. It aids in the management of inflammatory conditions, metabolic syndrome, arthritis, pain, and degenerative eye conditions. It may help in the management of exercise-induced inflammation and muscle soreness. In addition, a relatively low dose of curcumin can promote gut health, in people who do not have diagnosed health conditions. These benefits are best achieved when curcumin is combined with agents such as piperine (the chemical found in black pepper), which increases its bioavailability.
Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Curcumin, a major bioactive found in the rhizomes of turmeric, Curcuma longa L., is broadly used in the traditional system of Indian medicine owing to its antibacterial, antiviral, anticancer, and antifungal activities. Curcumin is suggested to be safe even at higher dosages (12 grams per day) and has fewer side effects. Curcumin and its bioconjugates have shown strong antiviral effects on different viruses, such as influenza viruses [PR8, H1N1, and H6N1], HSV-1, HSV-2, coxsackie virus B3 (CVB3), hepatitis B virus (HBV), human papilloma viruses (HPVs), and Japanese encephalitis virus (JEV) (ZorofchianMoghadamtousi et al. 2014). Studies suggest that curcumin majorly exhibits its antiviral effects by interfering with replication of various viruses (Kim and Kim 2015). Curcumin exhibits antitumour characteristics by downregulating NF-kB pathway in prostate cancer, arresting cell cycles in G2 and S phase of breast cancer cells, and colorectal cancer cells, and is involved in shrinking colon cancer cells and in hepatocellular carcinoma (Aggarwal et al. 2003).
Cardiovascular Risk Factors
Published in Nicole M. Farmer, Andres Victor Ardisson Korat, Cooking for Health and Disease Prevention, 2022
Curcumin is a major phenolic component of the spice turmeric. Curcumin has multiple functions that can affect CVD, including anti-inflammatory, antioxidant, and lipid-modifying. Several human trials have reported reduction of blood pressure levels with curcumin/turmeric administration (Hadi et al., 2019). However, the results from trials have provided conflicting evidence with some trials reporting no significant changes (Hadi et al., 2019). A meta-synthesis of 11 studies equating to 748 patients found that the duration of curcumin (≥12-weeks) is a significant factor in lowering SBP, a significant reduction in SBP with mean reduction of about 1.24 mmHg (Hadi et al., 2019). Possible mechanisms for the role of curcumin in blood pressure include increase bioavailability of nitric oxide (Santos-Parker et al., 2017) and downregulation of angiotensin-II receptor-1 (Yao et al., 2016).
Curcumin improves the ability of donepezil to ameliorate memory impairment in Drosophila melanogaster: involvement of cholinergic and cnc/Nrf2-redox systems
Published in Drug and Chemical Toxicology, 2023
Opeyemi Babatunde Ogunsuyi, Olayemi Philemon Aro, Ganiyu Oboh, Olawande Chinedu Olagoke
In many Asian and some African nations, turmeric (Curcuma longa L.) rhizomes are often used as spices, culinary additives, and traditional medicines (Govindarajan and Stahl 1980, Ademiluyi et al. 2012). The primary polyphenol found in turmeric (Curcuma longa), a member of the Zingiberaceae family, is called curcumin (CUR) (Kumar et al. 2009). Curcumin is well recognized for its powerful biological effects, which include antioxidant, anti-viral, anti-cancer, and anti-inflammation (Sharma et al. 2005). Previous research have shown that curcumin’s antioxidant, anti-inflammatory, and lipophilic actions help AD patients’ cognitive abilities (Mishra and Palanivelu 2008, Sahoo et al. 2021). In order to determine how this binary combination could affect memory index, along with the redox status, AChE activity and mRNA levels, as well as the capacity for cellular resistance to oxidants (cnc/Nrf2), this study examined the effect of curcumin plus donepezil in AlCl3-induced amnesia-like biochemical, molecular and phenotypic features in Drosophila.
Recent updates in curcumin delivery
Published in Journal of Liposome Research, 2023
Mohammad A. Obeid, Manal Alsaadi, Alaa A. Aljabali
Since curcumin acts as an inflammatory mediator, several publications and clinical trials have investigated the potential use of curcumin in the treatment of arthritis, which is a chronic disease characterised by dysregulation of inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF), in addition to many chemokines and inflammatory enzymes. This will result in severe joint inflammation resulting from that with the subsequent joint damage and disability (Salehi et al. 2019). In this regard, the clinical study of the curcumin-treated done by Deodhar et al. showed comparable results between the group receiving curcumin with the group receiving the non-steroidal anti-inflammatory agent phenylbutazone regarding the disease signs and symptoms such as the morning stiffness and joint swelling (Dcodhar et al. 2013). In another study, diclofenac sodium was reported to have better anti-inflammatory effects when administered to patients with rheumatoid arthritis in combination with curcumin, and the group that received this combination showed better improvement in disease scores such as the American College of Rheumatology (ACR) score and the Disease Activity Score (DAS) compared to the groups that received either drugs alone (Chandran and Goel 2012).
Co-delivery of curcumin and Bcl-2 siRNA to enhance therapeutic effect against breast cancer cells using PEI-functionalized PLGA nanoparticles
Published in Pharmaceutical Development and Technology, 2022
Leila Mohammad Gholinia Sarpoli, Shohreh Zare-Karizi, Erfan Heidari, Akbar Hasanzadeh, Mehrdad Bayandori, Fereshteh Azedi, Michael R. Hamblin, Mahdi Karimi
Extensive efforts have recently been made in the field of nanomedicine to develop an efficient and specific drug delivery system for breast cancer therapy. Several studies have focused on the potential role of curcumin as a promising anti-cancer drug (Vallianou et al. 2015; Arya et al. 2018). Nevertheless, the pharmacological limitations of curcumin (short plasma half-life, need for high dose, and poor aqueous solubility) have hindered its application in clinical studies (Arya et al. 2018). These limitations could be overcome by incorporating this natural compound into an efficient encapsulation system. The use of PLGA NPs is one option to overcome the aforementioned problems with curcumin delivery. PLGA possesses advantages such as good uptake by endocytosis, ease of preparation, high drug loading capacity, and a controlled drug release rate, which makes it an ideal candidate to serve as a nano delivery vehicle (Arya et al. 2018). In the current study, we encapsulated curcumin (with/without siRNA Bcl-2) into PEI-coated PLGA NPs, and tested them on the T47D breast cancer cell line.