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Antineoplastic Drugs during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Similar to vinblastine and vinblastine, vinorelbine is synthesized from a vinca alkaloid that has been used to treat breast cancer, lung cancer and other neoplasms. Three reports including 3, 20, 1, 1, and 1 pregnancies. Of the three infants exposed, in the first report, treatment began in the second trimester and three were apparently normal at 2 to 3 years of age (Cuvier et al., 1997). Among 20 pregnancies exposed to vinorelbine, two first trimester exposures resulted in spontaneous abortion, and one treated during the second trimester resulted in a fetal death. The findings were mainly limited to second and third trimester exposures, and 95 percent of those who survived (n = 17) had low birth weight and two had complications related to prematurity but were normal at >3 years of follow-up (Giaclone et al., 2000). In three case reports, multiple antineoplastic agents were used to treat breast and lung cancer with exposures beginning in the second trimester. Infants were normal at several years’ follow-up (De Santos et al., 2000; Janne et al., 2001; Fanale et al., 2005). Manufacturer’s information indicated IUGR in rats exposed during gestation at doses 25–33 percent of the usual human dose.
Chemotherapy in pregnancy
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Vinorelbine is a synthetic derivative of vinblastine. It is indicated in the treatment of non-small cell lung cancer, breast cancer, ovarian cancer, and HL. When administered to a patient with lung cancer from the 27th to 39th week of pregnancy, a healthy and normal infant resulted (93). Several other patients have reportedly received vinorelbine during pregnancy, with therapy being initiated between 15 and 29 weeks of gestation. In this setting, the drug has most commonly been administered as part of a combination of chemotherapies, being paired with 5-FU, cisplatin, or trastuzumab. All infants have been delivered without congenital abnormalities, had normal birth weights, and have been developing normally (94–96).
Antitubulin Agents
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
The search for new Vinca analogues has led to the second-generation semisynthetic analogs vindesine (EldesineTM) and vinorelbine (NavelbineTM), and more recently a third-generation bi-fluorinated semisynthetic analog vinflunine (JavlorTM) has been introduced. Vinorelbine, which is used for the treatment of advanced breast and non-small-cell lung cancer, is unique among the five agents in that it can be administered orally as well as intravenously. Vinflunine is also unique in being approved as a monotherapy for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a platinum-based regimen.
Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of gastric cancer
Published in Drug Development and Industrial Pharmacy, 2021
Xiu-ying Li, Luan-xia Shi, Xue-min Yao, Ming Jing, Qin-qing Li, Ying-li Wang, Qing-shan Li
Vinorelbine is a semi-synthetic vinca alkaloid antitumor drug commonly used cytotoxic agent. Vinorelbine specifically binds to tubulin during the process of cell mitosis, thereby inhibiting microtubule synthesis and further inducing microtubule disaggregation, which forces the mitosis of tumor cells to stop in the middle stage, thereby killing the tumor cells [22]. At the same time, vinorelbine can also inhibit the synthesis of protein by interfering with the transport of amino acids in the cell membrane, and promote the apoptosis of tumor cells [23]. Moreover, vinorelbine can yield sustainable antitumor activity possibly through antiangiogenic mechanisms [24]. Schisandrin B is a type of lignan that extracts from Schisandra chinensis (Turcz) Baill.B. In the past several years, schisandrin B has been revealed to possess multiple functions against tumor. It is reported that it can inhibit invasion and migration through the HOTAIR-micoRNA-125a-mTOR pathway and PI3K/Akt-mTOR-MMP-9 pathway to prolong survival time [25]. Meanwhile, schisandrin B induced apoptosis by up-regulating Bax, caspase-3, caspase-9, and cleaved PARP, and by downregulating cyclin D1, Bcl-2, and CDK-4 [26].
The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma
Published in Journal of Liposome Research, 2019
Xue-Tao Li, Wei Tang, Hong-Jun Xie, Shuang Liu, Xiao-Li Song, Yao Xiao, Xin Wang, Lan Cheng, Gui-Rong Chen
RGD (Arg-Gly-Asp) is a tripeptide composed of l-arginine, glycine, and l-aspartic acid. It is known to serve as a specific ligand for integrin ανβ3 subfamily, which is overexpressed on vascular endothelial cells and most malignant cancer cells including glioma cells, ovarian cancer cells, breast cancer cells, melanoma cells, and so on (Liu et al.2010, Li et al.2011, Zhang et al.2011). Vinorelbine is a cytostatic drug belonging to the vinca alkaloid family. It interferes with microtubule assembly and induces a cell cycle arrest at mitosis (Xu et al.2016). Vinorelbine has been used for treatment of breast cancer, non-small cell lung cancer, brain glioma, and other type of cancers (Cazzaniga et al.2016). Tetrandrine is one member of the bis-benzylisoquinoline alkaloids isolated from root of the traditional Chinese medicinal herb, Stephaniae tetrandrae. It has been broadly applied in treatment of silicosis, autoimmune disorders, inflammatory pulmonary diseases, cardiovascular diseases, and hypertension. It is also reported that tetrandrine could reverse MDR and inhibit the angiogenesis and metastasis in some solid tumours (Liu et al.2016b).
Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Yao Xiao, Lan Cheng, Hong-jun Xie, Rui-jun Ju, Xin Wang, Min Fu, Jing-jing Liu, Xue-tao Li
The quantification of cell apoptosis was detected by an Annexin V-FITC/PI apoptosis kit (Tianjin Sungene Biotech Co., Ltd., Tianjin, China) [25]. Briefly, C6 cells were seeded into 6 well culture plate at a density of 4 × 105 cells/well and cultured in F10 medium at 37 °C under 5% CO2 for 24 h. Then, C6 cells were incubated with the varying drug-loaded liposomes. The final concentration of vinorelbine was 0.1 μM and culture medium was used as blank control. After treatment for another 24 h, C6 cells were harvested, washed and resuspended in 200 μL of binding buffer. Then, the suspension was stained with annexin V-FITC and PI according to the manufacturer's instructions. After treatment for 10 min at room temperature in the darkness, the samples were analyzed by flow cytometer to determine the percentage of apoptotic cells. Each assay was repeated in triplicate.