China
Africa
Explore chapters and articles related to this topic
Non-steroidal anti-inflammatory drugs
Published in Gill Wakley, Ruth Chambers, Paul Dieppe, Musculoskeletal Matters in Primary Care, 2018
Gill Wakley, Ruth Chambers, Paul Dieppe
It is sensible to become familiar with the adverse profiles of a few NSAIDs. Include the selected drugs on your preferred drug list or practice formulary. For example, if you include tiaprofenic acid on your preferred list, you need to be aware that urinary frequency, dysuria, cystitis and haematuria may occur with this drug. Aseptic meningitis has very rarely been reported with the use of Ibuprofen. Sulindac may precipitate Stevens-Johnson syndrome (erythema multiforme with a variable rash, blisters in the mouth and other body openings, conjunctivitis and even corneal ulceration or perforation). Hypersensitivity rashes or asthma are possible with any of the NSAIDS. You are more likely to detect an adverse effect quickly, and discontinue the drug, if you are aware of the possibility that the clinical picture is likely to have an iatrogenic cause. If all members of the practice agree to use NSAIDs from a selected list, it will be much easier for all staff to be alert for possible adverse effects.
Clinical pharmacology: traditional NSAIDs and selective COX-2 inhibitors
Published in Pamela E Macintyre, Suellen M Walker, David J Rowbotham, Clinical Pain Management, 2008
Stephen F Jones, Aidan M O’Donnell
Between 50 and 80 percent of a dose of tiaprofenic acid is excreted unchanged in urine. Its excretion may be impaired in patients with renal disease (information from manufacturer’s data sheet). Tiaprofenic acid has been associated with severe cystitis, although typically this resolves upon its withdrawal. It is contraindicated in patients with urinary tract disorders.103 Its main indication is in the treatment of arthritis.
Cardiovascular safety of non-steroidal anti-inflammatory drugs revisited
Published in Postgraduate Medicine, 2018
Chris Walker, Luigi M. Biasucci
Traditional NSAIDs also have an effect on platelet function [35,36]; however, their effects are reversible, transient, and related to the half-life of the nsNSAID [37,38]. In addition, traditional NSAIDs particularly ibuprofen, indomethacin, tiaprofenic acid, and naproxen), when administered prior to or concurrently with aspirin, have been shown to consistently reduce the magnitude and duration of aspirin’s inhibitory effect on platelet aggregation through a process of competitive inhibition at the COX-1 active site [31,39–45]. Clinical data in this area are mixed, with some putative evidence for a detrimental effect of concomitant aspirin use in conjunction with ibuprofen [40], which was also seen in a prospective analysis of clinical trial data with regular use of NSAIDs generally [46], but not in a large cohort study [47] or a case–control study [48].
Pediatric cannabis poisonings in France: more and more frequent and severe
Published in Clinical Toxicology, 2021
Céline Chartier, Françoise Penouil, Ingrid Blanc-Brisset, Charlotte Pion, Alexis Descatha, Marie Deguigne
The sex ratio was 1:1 (female: 479 (49.6%), male: 485 (50.3%) and one child whose sex was not documented). The median age was 15 months (range, 6 months−10 years). In total, 84% of the cases involved children aged 0–2 years while 56.3% of the cases involved children less than 15 months old. The main characteristics of the study sample group are set out in Table 1. Nine hundred and twenty-seven (96%) children ingested only cannabis while 38 children ingested cannabis and other products. Co-ingested products were as follows: tobacco (n = 33, 3.5%), a medicine (n = 5, 0.5%: Benzodiazepines 2; Tramadol 1; Tiaprofenic acid 1; Dimethyl fumarate 1).
Cross-sectional study of patient satisfaction with oral analgesics in patients with chronic pain in Japan
Published in Expert Opinion on Pharmacotherapy, 2020
Takahiro Ushida, Teruyoshi Inoue, Daiju Matsui, Mizuka Yokoyama, Kazuhito Shiosakai, Kuniyuki Takeda, Katsushi Fukuoka, Osamu Nakagawa, Kaoru Okuizumi
Acemetacin, amfenac sodium, ampiroxicam, aspirin, aspirin dialuminate combination, celecoxib, diclofenac, etodolac, flufenamate aluminum, flurbiprofen, ibuprofen, indomethacin farnesyl, lornoxicam, loxoprofen, mefenamic acid, mofezolac, meloxicam, nabumetone, naproxen, oxaprozin, proglumetacin, sulindac, tiaprofenic acid, tiaramide, and zaltoprofen