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Suprofen
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic activities. It binds to the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes, preventing the synthesis of prostaglandins and reducing the inflammatory response. Currently, it appears not to be used systemically, but suprofen is utilized in eye drops to inhibit the miosis (pupil constriction) that may occur during ocular surgery (1). It is also available since 1989 in Japan in an ointment containing 1% suprofen (1,3). All reports of (photo)contact allergy thus far have come from Japan, with the exception of one patient who was sensitized during a clinical trial (12).
Effects of Antithrombotic and Results of Drug Screening
Published in Josef Hladovec, Antithrombotic Drugs in Thrombosis Models, 2020
A new type of NSAID is represented by benzydamine which differs from other agents in many respects and also possesses an oxygen-free radical scavenging activity. It prevented thrombosis after the insertion of a wire coil into the vena cava in rats.703 The effects of another drug, suprofen, were reviewed by Todd et al.704 It also inhibited mortality after arachidonic acid in rats.705
Metabolomics markers in Neurology: current knowledge and future perspectives for therapeutic targeting
Published in Expert Review of Neurotherapeutics, 2020
Roberta Bonomo, Guido Cavaletti, Debra J. Skene
Chemotherapy-induced peripheral neuropathy (CIPN) is a common drug-related adverse effect of anti-neoplastic treatment [212]. Despite the fact that a clear mechanism has yet to be defined, mitochondrial dysfunction [213–216], intraepidermal nerve fiber damage [215], dysfunctional ion channels [217–219], inflammatory and immune status [220–222] seem to contribute to the pathogenesis of nerve damage. Wu and colleagues investigated metabolomics changes in patients treated with paclitaxel-induced CIPN [223]. The ultra-performance liquid chromatography-electrospray ionization-mass spectrometer (UPLC-ESI-MS) analysis revealed a decrease of PCs and LysoPCs, indoxyl sulfate, suprofen S-oxide, and 4-ethylphenylsulfate. Metabolism of fatty acids, involved in the biosynthesis of prostaglandins and cell membranes, and glycerophospholipids, which provide stability, permeability and fluidity to cell membranes, was primarily affected by paclitaxel. These findings support other previous studies reporting alterations in lipids (LysoPCs or PCs), organic acids and ketones in paclitaxel-related CIPN [224–226].