China
Africa
Explore chapters and articles related to this topic
Essential Oils: Clinical Perspectives And Uses
Published in Amit Baran Sharangi, K. V. Peter, Medicinal Plants, 2023
Jugreet Bibi Sharmeen, Mahomoodally Mohamad Fawzi
Nonetheless, Malhi et al. (2017) evaluated the tolerability, efficacy, and acceptability of a tea tree oil gel and face wash in treating mild to moderate facial acne in an open-label, uncontrolled phase II pilot study. For this purpose, participants applied tea tree oil products on their face twice daily for 12 weeks and assessments were done at 4th, 8th, and 12th weeks. The total lesion counts as well as the mean investigator global assessment were found to differ significantly over time that is from baseline to 12 weeks. No serious AEs occurred and only minor local tolerability events which were restricted to dryness, peeling, and scaling, were reported to be resolved without intervention. This study thus suggested the efficacy and tolerability of these tea tree oil products in improving mild to moderate acne.
Monographs of fragrance chemicals and extracts that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
alpha-Terpinene is a colorless to pale yellow clear oily liquid; its odor type is woody and its odor at 10% is described as ‘citrusy, woody, terpy with camphoraceous and thymol notes. It has spicy and juicy citrus nuances’ (www.thegood scentscompany.com). alpha-Terpinene is a naturally occurring cyclic monoterpene produced in the secondary metabolism of plants. It has been identified in numerous plant extracts and is a constituent of several commonly used essential oils, especially tea tree oil (see ‘Presence in essential oils’ below and Chapter 6.71 Tea tree oil). α-Terpinene is sometimes present in fragrances at low levels as part of natural oils that are used in the actual fragrances. The chemical has antioxidant activity and it is one of the most important constituents responsible for the antioxidant activity of tea tree oil.
Aromatic Medicine
Published in Anil K. Sharma, Raj K. Keservani, Surya Prakash Gautam, Herbal Product Development, 2020
Sakshi Bajaj, Himangini Bansal
In a single blind and parallel-group study, it was seen that shampoos which contain 5% tea tree oil were compelling and very much endured by patients having gentle to moderate dandruff and at least 41% improvement was observed (Satchell et al., 2002). Not much have been investigated on the antidandruff capability of plant products, and particularly on volatile products, a few endeavors have been made by Anjum et al, yet the outcomes are not promising (Anjum et al., 2014).
Dermocosmetics: beneficial adjuncts in the treatment of acne vulgaris
Published in Journal of Dermatological Treatment, 2021
Elena Araviiskaia, Jose Luis Lopez Estebaranz, Carlo Pincelli
Antimicrobial agents, such as decanediol and tea tree oil, are used in dermocosmetics for acne (26–28). Decanediol has an antibacterial effect against C. acnes (29). This antibacterial action resulted in a significant reduction in pustules and sebum levels during an 8-week treatment period in patients with mild-to-moderately severe acne (29). Tea tree oil reduced the appearance and severity of both inflammatory and non-inflammatory acne lesions with few side effects (28,30). In the study by Bassett et al. (28), the onset of action for tea tree oil (5%) was slower than benzoyl peroxide (BPO); the efficacy of BPO has been well-documented in acne but is associated with skin irritation (31). Bakuchiol is another agent with antimicrobial efficacy against a number of bacteria including Staphylococcus (32,33), additional anti-aging, anti-inflammatory, photoprotective and sebum controlling effects have also been documented (34–36).
Non‐pharmaceutical treatment options for meibomian gland dysfunction
Published in Clinical and Experimental Optometry, 2020
Demodex mites are resistant to a wide range of antiseptic agents, including 75% alcohol, 10% povidone‐iodine, and erythromycin.2007In vivo microscopic observation for 150-minutes revealed that D. folliculorum was killed by tea tree oil in a dose‐dependent manner.2007 In addition to this action, tea tree oil has been found to manifest antibacterial,2004 antifungal,2004 and anti‐inflammatory2004 effects. Terpinen‐4‐ol, a terpene with antimicrobial, antifungal, antiviral, antiseptic, and acaricidal properties, is the active ingredient of tea tree oil with regard to the killing of Demodex mites.2013 A concentration of tea tree oil as low as 5% applied to the lids and base of the eyelash follicles twice daily or as high as 50% applied once weekly was found to attenuate Demodex infestation.2013 However, tea tree oil can cause dermatitis, allergy, and ocular irritation, especially at higher concentrations,2012 and treatment to eradicate Demodex completely is often unrealistic.
Consumer preferences of antifungal products for treatment and prevention of tinea pedis
Published in Journal of Dermatological Treatment, 2019
Most products included additional claims including ‘preservative, scent, dye-free,’ ‘all natural ingredients,’ or ‘animal safe.’ Although these factors may carry importance for some patients, physicians should counsel consumers on the accuracy and significance of these labels in terms of safety and treatment efficacy. For example, many of the top products include and/or advertise tea tree oil as an effective and natural ingredient in eradicating athlete’s foot and other fungal infections. Although there have been two studies evaluating the efficacy of tea tree oil in treating athlete’s foot (14), the evidence for mycological cure rates is lacking, along with an insufficient quantity of clinical trials assessing this and other essential oils when compared to approved antifungal active ingredients such as azoles or allylamines (13). Specifically to date, there have been no studies evaluating antifungal activity against Trichophyton rubrum, a common organism causing tinea pedis (6). Additionally, there is no data to support other antifungal soaks with various ‘natural salts’ listed as the main advertised ingredients. Our study shows that consumers put less emphasis on product ingredients, since they were infrequently listed as either a positive or negative feature. Therefore, patients must be educated regarding appropriate use of ‘natural’ versus FDA approved antifungal products.