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Monographs of essential oils that have caused contact allergy / allergic contact dermatitis
Published in Anton C. de Groot, Monographs in Contact Allergy, 2021
A male patient presented himself with an itchy dermatitis on the forearms, backs of the hands, and legs. His job was to repair agricultural engines. By doing this, he had developed irritant contact dermatitis of the hands from contact with oil, frequent washing, and mechanical stress to the skin. For 2 months, the patient had been using neem oil on his hands, arms, and legs to treat his dry skin. Within 2 weeks, an itchy rash appeared at the sites of application. Patch tests revealed positive reactions to sodium metabisulfite, ketoconazole cream (which contains sodium sulfite), and neem oil. The product contained 99.9% neem oil and 0.1% tocopherol. Later, the patient was tested with tocopherol 10% and 30% in arachis oil and retested with the neem oil, which again gave a positive reaction to the oil; there were no reactions to tocopherol. Twenty-three controls were tested with the neem oil product with negative results. The reactions to sodium metabisulfite and ketoconazole cream were of past relevance (12).
Pitfalls and Practical Solutions
Published in Joseph Chamberlain, The Analysis of Drugs in Biological Fluids, 2018
Sodium metabisulfite is a commonly used preservative for urine samples; however, it may also have an inhibitory effect on enzymic hydrolysis of conjugates as has been demonstrated for its effect on sulfatases used in the enzymic hydrolysis of 4-hydroxyantipyrine sulfoconjugate.1386
Contact Urticaria Syndrome from Foods and Food Derivatives
Published in Ana M. Giménez-Arnau, Howard I. Maibach, Contact Urticaria Syndrome, 2014
Angèle Soria, Pascale Mathelier-Fusade
Sulfites and derivatives agents (sulphur dioxide, sodium sulfite, sodium bisulfite, sodium metabisulfite) are widely used as preservatives and antioxidant additives in many foods, beverages (sulfur dioxide were encountered especially in wines and beers), and pharmaceutical industries. Various clinical manifestations were described with topical, oral, or parenteral exposure to sulfites occurring a few minutes after ingestion or inhalation (i.e., flushing, urticaria, angioedema, diarrhea, nausea, abdominal pain, bronchospasm, hypotension, and anaphylactic reactions). Metabisulfites are incriminated in urticaria and angioedema reactions, not with contact urticaria.[71]
A randomized open label, parallel-group study to evaluate the hemodynamic effects of Cafedrine/Theodrenaline vs Noradrenaline in the treatment of intraoperative hypotension after induction of general anesthesia: the “HERO” study design and rationale
Published in Current Medical Research and Opinion, 2023
Benjamin Vojnar, Götz Geldner, Susanne Huljic-Lankinen, Melanie Murst, Thomas Keller, Stephan Weber, Christine Gaik, Tilo Koch, Andreas Weyland, Peter Kranke, Sascha Kreuer, Daniel Chappell, Leopold Eberhart
Patients are not included if there is any known hypersensitivity to Sodium Metabisulfite or any of the components of medicinal products as per their SmpCs and/or bronchial asthma with sulfite hypersensitivity. In addition, patients are excluded with underlying conditions (clinically relevant mitral stenosis, clinically relevant aortic stenosis, hyperthyroidism, pheochromocytoma, uncontrolled hypertension) or undergoing treatments with cardiac sensitizing agents or co-medications that negatively affect the effectiveness of the medicinal products (ACE-Inhibitor/AT2-Antagonists or MAO-Inhibitors on the day of surgery). Furthermore, patients are excluded if they have sepsis, septic shock, or systemic inflammatory response syndrome, if there is use of regional or inhalation anesthesia during bolus- and/or infusion phase, and/or if a female patient cannot exclude pregnancy.
Possible effects of excipients used in the parenteral drugs administered in critically ill adults, children, and neonates
Published in Expert Opinion on Drug Safety, 2020
Kannan Sridharan, Hasan MSN Hasan, Muna Al Jufairi, Amal Al Daylami, Eman Al Ansari, Ali Mohammed Qader, Sheikh Abdul Azeez Pasha
A summary of the individual excipients administered in the study population is provided in Table 3. Majority of the participants received either hydrochloric acid or sodium hydroxide as pH modifier but exact quantity was not stated for the former and in most of the preparations for the latter. Following these buffers, sodium chloride was the major excipient. Benzyl alcohol (65/1072 prescriptions; 6 drugs), polysorbate 80 (3/1072 prescriptions; 1 drug), propylene glycol (23/1072 prescriptions; 3 drugs), propyl paraben (158/1072 prescriptions; 2 drugs), and methyl paraben (158/1072 prescriptions; 2 drugs) were the harmful excipients administered to the neonates. Sodium metabisulfite (208/1072 prescriptions; 5 drugs), monobasic sodium phosphate (13/1072 prescriptions; 13 drugs), dibasic sodium phosphate (32/1072 prescriptions; 2 drugs), disodium edetate (187/1072 prescriptions; 5 drugs), macrogol (3/1072 prescriptions; 1 drug), calcium chloride (3/1072 prescriptions; 1 drug), and lactic acid (3/1072 prescriptions; 1 drug) were the potentially harmful excipients administered to the neonates.
Recent developments on treatment strategies and the prognosis of dermatomyositis: a review
Published in Journal of Dermatological Treatment, 2018
Verena Isak, Joseph L. Jorizzo
A particularly difficult to treat skin manifestation of DM is calcinosis cutis. In a case series of four patients, topical 25% sodium metabisulfite led to a size reduction of the lesions (138). Topical, IV, as well as intradermal sodium thiosulfate was successfully used to treat refractory calcinosis (119,139,140). Treatment of DM-associated calcinosis cutis with IVIG has shown mixed results, with anecdotal success in one patient (141), prevention of recurrence of calcinosis with doses on 2 consecutive days each month in another patient (142), but no improvement in two patients after 5 years of IVIG treatment (143). Rituximab was ineffective in altogether eight patients (106,144). Iorizzo and Jorizzo report surgical removal to be the most effective treatment for especially larger lesions (21).