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Hybrid Nanosystems
Published in Carla Vitorino, Andreia Jorge, Alberto Pais, Nanoparticles for Brain Drug Delivery, 2021
Pablo Vicente Torres-Ortega, Laura Saludas, Jon Eneko Idoyaga, Carlos Rodríguez-Nogales, Elisa Garbayo, María José Blanco-Prieto
Despite the promising future of HNs, this technology is still at a premature stage and further studies should demonstrate its efficacy on more accurate in vivo models before its translation to clinical trials. Furthermore, the relative toxicity of inorganic compounds is still one of the main concerns for the use of these systems in brain-related disorders and rigorous evaluation of the possible toxicity and negative effects associated with these systems is necessary [55]. Approaches to develop reproducible methodologies and feasible scale-up synthesis of hybrid nanomaterials are also needed. A regulatory framework should also be defined in order to progress in this technology. Therefore, further efforts should be focused on the development of suitable specific guidelines able to harmonise related issues with safety, efficacy evaluation and manufacturing processes.
Conclusion
Published in Nate F. Cardarelli, Tin as a Vital Nutrient:, 2019
At this point in the text ancillary chapters were inserted that broaden our knowledge about the physiological activity of tin. Dr. Thayer’s paper reported on the investigation of the effect of several tin compounds on the growth and development of plant cells. Both organic and inorganic compounds were evaluated. A wide range of effects were noted, with a crucial factor being the nature of the groups bonded to the tin atom. Microbes in nature appear to resist organotin movement through the cell envelopes by surface absorption and binding. It is postulated that the change in growth parameters, especially lag time, observed under tin stress arises from the need of the organism to modify its cell membrane in order to prevent tin movement into the cell. The data presented reasonably indicate that tin-cell membrane reactions occur.
Preparation of Low Molecular Weight Copper Complexes
Published in Robert A. Greenwald, CRC Handbook of Methods for Oxygen Radical Research, 2018
Syntheses of low molecular weight copper complexes are usually straightforward and do not require expensive equipment. At the outset, the ligand and inorganic compound must be established as chemically pure. A ligand can usually be identified as chemically pure if its melting point, color, and spectral characteristics agree with published values. If a ligand is found to be impure, it can often be purified by distillation or recrystallization from a solvent listed either in compendia providing physical properties of pure compounds or in the original publication reporting the synthesis of the ligand. ACS reagent-grade inorganic compounds are usually chemically pure and can be purchased from a variety of chemical suppliers.
The combined effect of essential oils on wood physico-chemical properties and their antiadhesive activity against mold fungi: application of mixture design methodology
Published in Biofouling, 2023
Moulay Sadiki, Mounyr Balouiri, Soumya Elabed, Fadoua Bennouna, Mohammed Lachkar, Saad Ibnsouda koraichi
The microbial colonization of wood and historic wooden objects by various microorganisms, especially, rot fungi, cause its biodeterioration and decomposition (Blanchette et al. 2004, 2021; Nitiu et al. 2020; Savković et al. 2022). To improve and increase the lifespan of this material many preservatives treatment have been used, including thermal and chemical modifications, synthetic and inorganic compounds, and fungitoxic chemicals (oil-borne preservatives) (Stirling et al. 2014; Blanchet and Pepin 2021; Woźniak 2022). However, these treatments were unadvised and restricted in different countries due to their potentially harmful and toxic effects on the environment as well as the risk presented to human health (Stirling et al. 2014; Morais et al. 2021). Therefore, the search for new ecofriendly and green wood preservatives has become the main objective and goal of several research centers worldwide. Natural products, mainly from aromatic and medicinal plants, including plant extracts, essential oils, alkaloids, and others have been used and investigated as alternative agents in wood protection against rot fungi (Singh and Singh 2012; Pánek et al. 2014).
Molecular docking, quorum quenching effect, antibiofilm activity and safety profile of silver-complexed sulfonamide on Pseudomonas aeruginosa
Published in Biofouling, 2021
Fallon dos Santos Siqueira, Camilla Filippi dos Santos Alves, Alencar Kolinski Machado, Josiéli Demétrio Siqueira, Thiago dos Santos, Caren Rigon Mizdal, Kelly Schneider Moreira, Diogo Teixeira Carvalho, Pauline Codernonsi Bonez, Carolina Gonzalez Urquhart, Roberto Christ Vianna Santos, Michele Rorato Sagrillo, Lenice de Lourenço Marques, Davi Fernando Back, Marli Matiko Anraku de Campos
From the point of view of technological design, the synthesis and development of metallodrugs (metal-based drugs) is a great challenge, especially when it comes to inorganic compounds. The bioaccumulation of metal ions can cause serious adverse side effects, which require accurate pharmacological investigation, also considering physiological and toxicological aspects (Rocha et al. 2011; Sagrillo et al. 2015). Therefore, the SMTZAg in vitro safety profile was investigated, in order to prove the safety of this compound before a possible in vivo evaluation. PBMCs were used for this, as these cells have been an excellent experimental model in the field of cyto-genotoxic understanding (Boligon et al. 2009; Boligon et al. 2012; Sagrillo et al. 2015). After SMTZAg exposure for 24 h, cells were tested to assess the viability index, genotoxic effects, and possible hemolysis induction, as well as some oxidative parameters, including the determination of NO and ROS production. The concentrations of the compound chosen to evaluate the cellular effects were selected based on the MIC previously obtained.
MiADMSA abrogates sodium tungstate-induced oxidative stress in rats
Published in Drug and Chemical Toxicology, 2022
Sherry Sachdeva, Ankita Sharma, S. J. S. Flora
The impairment of biometals can be attenuated by using chelation therapy utilizing various metal chelators. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. These agents are organic or inorganic compounds capable of binding metal ions to form a complex ring-like structure called ‘chelates’. They possess “ligand” binding atoms that form either two covalent linkages or one covalent and one co-ordinate or two co-ordinate linkages in the case of bi-dentate chelates. Bi-dentate or multi-dentate ligands form ring structures that include the metal ion and the two-ligand atoms attached to the metal (Aaseth et al. 2015).