China
Africa
Explore chapters and articles related to this topic
Medicinal Plants of China Focusing on Tibet and Surrounding Regions
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Jiangqun Jin, Chunlin Long, Edward J. Kennelly
Bioactivities: Anticancer (Li et al., 2016), antibiofilm, anti-inflammatory (Chiang et al., 2015), liver toxicity protection activities (Lee et al., 2015; Lin et al., 2016); antioxidant, antihypoxia, radioprotective activities (Chang et al., 2018); immunomodulatory, anti-aging, anti-fatigue, neuroprotective, anxiolytic, nootropic, life-span increasing and central nervous system (CNS)-stimulating activities (Varela et al., 2016); antidiabetic, estrogenic activities (Bhardwaj et al., 2018). Salidroside could scavenge intracellular free radicals, and the phenolic compounds had antioxidants effects and could moderately stimulate IFN-γ expression (Bhardwaj et al., 2018).
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
In the Zucker diabetic fatty rat, an animal whose metabolic anomalies simulate the condition of metabolic syndrome in humans, treatment with Rhodiola crenulatadecreased fasting plasma insulin levels and enhanced insulin sensitivity in the homeostasis model assessment of insulin resistance. The crenulata species of Rhodiola rosea is closely related to rosea and contains significant concentrations of active salidroside.9 Indeed, similar to the effects of ketamine and many substances with antidepressant effects, salidroside ameliorates insulin resistance through activation of a mitochondria‐associated AMPK/PI3K/Akt/GSK-3β pathway.10 Aqueous extracts of Rhodiola rosea also reduce serum glucose levels in rats made diabetic by treatment with streptozotocin. Interestingly, this effect is eliminated by adrenalectomy, and is thought to be mediated by stimulation of adrenal release of β-endorphin.11
Therapeutic Implications of Rhodiola sp. for High Altitude Maladies: A Review
Published in Megh R. Goyal, Durgesh Nandini Chauhan, Plant- and Marine-Based Phytochemicals for Human Health, 2018
Kalpana Kumari Barhwal, Kushal Kumar, Suryanarayan Biswal, Sunil Kumar Hota
The genus Rhodiola L. (Crassulaceae) consists of approximately 100 species, distributed in the mountainous regions of Southwest China and the Himalayas, where the environment is vulnerable to unfavorable conditions.6, 41, 78 Use of Rhodiola in the traditional system of medicine can be traced back to as early as 300 anno Domini (A. D.: in the year of Lord), based upon its description in the Handbook of Traditional Tibetan Drugs among 175 most important Tibetan drugs.64Rhodiola was used to treat lung diseases, particularly lung-heat disorders. It is mentioned in the Handbook of Traditional Tibetan Drugs in 10 formulations out of which nine are for the treatment of lung diseases.40, 64 One of the species of Rhodiola, namely Rhodiola rosea (commonly called as golden root, rose root, roseroot, western roseroot, Aaron’s rod, Arctic root, king’s crown, lignum rhodium, orpin rose) has also been included in the Ayurveda (traditional Indian system of medicine) as an adaptogen.57 In addition to this, Rhodiola has also been used in traditional medicine in European countries like Russia.13 Out of 100 species of Rhodiola, R. rosea and Rhodiola imbricata have been extensively reported in recent literature for their adaptogenic,18, 33 immunomodulatory,46 memory-enhancing,51 and radioprotective properties.2, 11 Approximately, 140 compounds have been isolated from the root and rhizome of R. rosea.51 The isolated compounds are of different classes that include essential oils, trans-cinnamic alcohol glycosides, flavonoids, organic acids, fats, phenolics including tannins and proteins.34 Salidroside is a principal phenolic compound isolated from Rhodiola, other than rosavin, triandrin, and tyrosol.37
Salidroside Inhibits Ganglion Cell Apoptosis by Suppressing the Müller Cell Inflammatory Response in Diabetic Retinopathy
Published in Current Eye Research, 2023
Jing Li, Wenqiang Liu, Yufei Wang, Anqi Liu, Shengxue Yu, Hongdan Yu, Zhongfu Zuo, Xuezheng Liu
Rhodiola rosea is widely distributed in high-altitude areas and has long been used as a medicinal herb.22 Salidroside (SAL) is the main medicinal component of R. rosea. Previous studies have shown that the SAL performs anti-hypoxic, anti-inflammatory, and anti-aging functions, exerts anti-fibrotic activity, and enhances immunity.23–25In vitro, SAL also inhibits hepatic gluconeogenesis and lipid accumulation.26,27 However, the specific role and mechanism of SAL in DR, as well as the underlying mechanism, are not known. Moreover, whether SAL affects RGCs through the inflammatory response of Müller cells has not been reported. Therefore, it is important to actively explore the effect of SAL on Müller cells and RGCs during the pathogenesis of DR, to explore effective therapeutic drugs for the treatment of DR, and to provide a theoretical basis for the possible use of SAL as a drug target for the effective treatment of DR.
Protective effect of salidroside on streptozotocin-induced diabetic nephropathy by inhibiting oxidative stress and inflammation in rats via the Akt/GSK-3β signalling pathway
Published in Pharmaceutical Biology, 2022
Delong Pei, Shengri Tian, Yanqiu Bao, Jun Zhang, Dongyuan Xu, Minhu Piao
Salidroside (SAL) is a phenylpropanoid glycoside obtained from the roots of Rhodiola rosea L. (Crassulaceae) (Zheng et al. 2015). The concentration of SAL extracted from the root extract is 2.7%. It has also been shown to protect cardiomyocytes from oxidative stress by activating the PI3K/Akt pathway (Zheng et al. 2015). Moreover, it also stimulates glucose uptake in skeletal muscle cells by activating AMP-activating protein kinase (AMPK) in vivo (Zheng et al. 2015). SAL exerts a variety of beneficial pharmacologic effects, including antioxidant (Xiao et al. 2014), anti-inflammatory (Lanza et al. 2001), and anti-apoptotic (Zhu et al. 2015) effects, and have shown to improve mitochondrial function (Zhang et al. 2015). Moreover, the role of SAL in preventing apoptosis has been reported in pheochromocytoma (PC12) cells, SH-SY5Y neuroblastoma cells, and cardiomyocytes. However, little is known about its effects on the apoptosis of proximal tubular epithelial cells induced by diabetes (Guo et al. 2018). Despite showing an array of pharmacologic properties, the suitability of SAL as a potential candidate for the treatment of DN remains unexplored till date. Therefore, the present study aimed to examine the effects and underlying mechanisms of SAL on streptozotocin (STZ)-induced DN using a rat model.
Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9
Published in Pharmaceutical Biology, 2021
Hui Zhang, Wenwen Dong, Siyuan Li, Yunqian Zhang, Zhou Lv, Lu Yang, Lai Jiang, Tao Wu, Yan Wang
Salidroside is one of the effective ingredients of Rhodiola rosea L. (Crassulaceae), which has been widely used as a traditional herb in Asia and Eastern Europe (Mattioli et al. 2009). Accumulating evidence has shown that salidroside possesses several pharmacological properties, such as anti-inflammatory (Wang et al. 2015) and antioxidant activities (Zhang et al. 2007), as well as cardioprotective (Zhu et al. 2015) and neuroprotective effects (Wang et al. 2015). It has also been reported that salidroside alleviates LPS-induced lung injury (Guan et al. 2012) and caecal ligation and puncture (CLP)-induced sepsis in mouse models (Lan et al. 2017). However, the effects of salidroside on endothelial permeability remain unknown. As a consequence, the present study investigates the pharmacological role of salidroside in mechanical stretch-induced endothelial dysfunction and ventilation-induced lung injury.