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Medicinal Plants of Mongolia
Published in Raymond Cooper, Jeffrey John Deakin, Natural Products of Silk Road Plants, 2020
Narantuya Samdan, Odonchimeg Batsukh
Rhodiola rosea L. (Figure 1.21) is a common member of the family Crassulaceae, known as one of the most important popular medicinal plants of northern Europe as well as in Mongolia. The plant is found only in a severe alpine climate and grows very slowly. It is 20–40 cm tall, perennial, and a flowering herb. The rhizome is branched, golden yellow or gray-brown, with many emerging erect stems. The plant grows on scree and stony riverbanks in the mountainous areas of Khovsgol, Khentei, Khangai, Khovd, Mong. Altai, Dund. Khalkh, and Gobi-Altai (Ligaa et al., 2005).
Herbs with Antidepressant Effects
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
In animal studies, Rhodiola rosea has also been shown to exert a potent anti-inflammatory effect. In the carrageenan‐induced paw edema, formaldehyde‐induced arthritis, and nystatin‐induced paw edema models of inflammation rats, extracts of Rhodiola rosea exhibited inhibited acute and subacute inflammation. It appeared to do so by inhibiting the activities of the enzymes, cyclooxygenase‐2 and Phospholipase A2.5
Recent Insights on the Role of Natural Medicines in Immunostimulation
Published in Dilip Ghosh, Pulok K. Mukherjee, Natural Medicines, 2019
Isabella Muscari, Sabrina Adorisio, Trinh Thi Thuy, Tran Van Sung, Domenico V. Delfino
Rhodiola rosea (also known as golden root or arctic root). This plant belongs to the Crassulaceae family and is used for treating different diseases in traditional medicine. Studies have proposed that Rhodiola rosea exerts immunopotentiating effects. Specifically, its ethanolic root extract inhibits T lymphocyte apoptosis, thus increasing their number and the expression of Th1 cytokines (IFN-γ, IL-2, and IL-12) (Kaur et al. 2017).
Comprehensive viewpoints on heart rate variability at high altitude
Published in Clinical and Experimental Hypertension, 2023
Jun Hou, Keji Lu, Peiwen Chen, Peng Wang, Jing Li, Jiali Yang, Qing Liu, Qiang Xue, Zhaobing Tang, Haifeng Pei
Chinese herbal medicines are widely utilized in the prevention and treatment of hypoxia-related diseases due to their notable therapeutic effects and minimal adverse reactions. Rhodiola rosea is a prominent anti-altitude sickness drug that is extensively used for its ability to reduce oxygen consumption and enhance oxygen-carrying capacity. Chinese herbs like Salvia miltiorrhiza, Dracocephalum heterophyllum Benth, and Lycium chinense Miller also possess properties that reduce tissue and organ damage caused by hypoxia. They can alleviate the degree of hypoxia in the body, thus mitigating the symptoms of altitude sickness. Both animal and clinical trials have demonstrated that Rhodiola rosea and its extract can improve HRV (111–113). Similarly, Salvia polyphenolic acid salt and Compound Salvia injection have shown improvements in HRV in cases of elderly coronary heart disease and chronic heart failure (114,115). Apart from individual herbal medicines with notable efficacy, compound medications and combination therapies offer a more comprehensive approach for addressing high altitude hypoxia-related diseases. Time-Domain-Analysis-Methods have indicated that Buqi Zhitong decoction and Tongluo Anxin decoction have positive effects on improving HRV (116,117). However, there is still a lack of direct research on high altitude HRV specifically related to natural anti-altitude sickness drugs such as Cordyceps, Salvia, and Dracocephalum tanguticum.
Salidroside Inhibits Ganglion Cell Apoptosis by Suppressing the Müller Cell Inflammatory Response in Diabetic Retinopathy
Published in Current Eye Research, 2023
Jing Li, Wenqiang Liu, Yufei Wang, Anqi Liu, Shengxue Yu, Hongdan Yu, Zhongfu Zuo, Xuezheng Liu
Rhodiola rosea is widely distributed in high-altitude areas and has long been used as a medicinal herb.22 Salidroside (SAL) is the main medicinal component of R. rosea. Previous studies have shown that the SAL performs anti-hypoxic, anti-inflammatory, and anti-aging functions, exerts anti-fibrotic activity, and enhances immunity.23–25In vitro, SAL also inhibits hepatic gluconeogenesis and lipid accumulation.26,27 However, the specific role and mechanism of SAL in DR, as well as the underlying mechanism, are not known. Moreover, whether SAL affects RGCs through the inflammatory response of Müller cells has not been reported. Therefore, it is important to actively explore the effect of SAL on Müller cells and RGCs during the pathogenesis of DR, to explore effective therapeutic drugs for the treatment of DR, and to provide a theoretical basis for the possible use of SAL as a drug target for the effective treatment of DR.
The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial
Published in Journal of Dietary Supplements, 2021
Eric D. Ryan, Gena R. Gerstner, Jacob A. Mota, Eric T. Trexler, Hayden K. Giuliani, Malia N. M. Blue, Katie R. Hirsch, Abbie E. Smith-Ryan
There is a growing number of herbal extracts that are marketed as ergogenic aids. Rhodiola rosea is an herb found at higher altitudes throughout Europe, Asia, and North America, with various applications dating back hundreds of years (Panossian et al. 2010). Recent studies (De Bock et al. 2004; Noreen et al. 2013) have reported positive improvements in aerobic cycling performance (e.g. time trial and time to exhaustion) following an acute supplementation of Rhodiola rosea extract (RRE). These studies (De Bock et al. 2004; Noreen et al. 2013) have suggested that improved performance is due to an altered perception of effort, which may be linked to altered endogenous opioid production. This was supported by Duncan and Clarke (2014) who reported lower RPE values during exercise and improved perceptions of arousal, pleasure, and vigor following 30 min of submaximal cycling. Studies examining the influence of acute RRE supplementation on anaerobic performance is limited. A very recent paper (Ballmann et al. 2019) indicated that mean power output and total work, but not the fatigue index, was improved during repeated Wingate assessments. However, the acute supplementation (500 mg) was preceded by three days of supplementation (1,500 mg/day). Thus, future studies are needed to determine the influence of an acute only RRE supplementation strategy on anaerobic performance.