China
Africa
Explore chapters and articles related to this topic
Fatigue/Chronic Fatigue Syndrome
Published in Charles Theisler, Adjuvant Medical Care, 2023
Medical causes of fatigue include depression, sleep apnea, anemia (e.g., iron deficiency anemia), cardiac failure, chronic diseases (e.g., COPD or hypothyroidism), and drug therapy, (e.g., antidepressants, antihypertensives, cytokines/interferon, and anticancer medications). If fatigue is the result of an underlying condition, then treatment depends upon that condition. Any comorbidity identified should be treated.
Collaborative Ecological Community Interventions for People with Chronic Fatigue Syndrome
Published in Christopher B. Keys, Peter W. Dowrick, People with Disabilities, 2021
Leonard A. Jason, Amy M. Kolak, Tonya Purnell, Dan Cantillon, Jennifer M. Camacho, Susan Klein, Allison Lerman
Chronic fatigue syndrome (CFS) appears to be a heterogeneous disease syndrome that may be triggered by a variety of factors (Jason, Wagner et al., 1995). The most prominent symptom is persistent fatigue for at least 6 months. Other symptoms commonly reported include: mild fever or chills, sore throats, painful lymph nodes, unexplained generalized muscle weakness, muscle discomfort, prolonged generalized fatigue after levels of exercise, generalized headaches, joint swelling, neuropsychiatric complaints, and sleep disturbances. Relatively few patients recover, with most continuing to experience decreases in exercise tolerance and mild CFS-related symptoms which are exacerbated during periods of stress and minor illness (Wilson et al., 1994). While there are several theories of etiology of this syndrome, considerable controversy exists about the nature of the possible biological, psychological, constitutional and genetic contributory factors (Friedberg & Jason, 1997). This lack of agreed upon and established etiology presents researchers with a unique challenge: how to conduct research in a sensitive and comprehensive way, and not inadvertantly stigmatize those with this illness as having a “psychiatric illness.”
Chronic Fatigue Syndrome: Limbic Encephalopathy in a Dysregulated Neuroimmune Network
Published in Jay A. Goldstein, Chronic Fatigue Syndromes, 2020
Fatigue is a common symptom associated with many medical disorders which needs to be considered when evaluating a patient. Common causes of fatigue include viral, infectious or inflammatory syndromes, endocrine disorders, and autoimmune diseases. Heart failure, chronic lung diseases, anemia, malabsorption, hepatic and renal failure all may be associated with fatigue due to inadequate delivery of nutrients and oxygen to various organ systems. Almost any chronic illness can cause fatigue, and neoplastic disorders should always be considered. Adverse drug reactions and ingestion of alcohol, toxins, or illicit substances may also produce fatigue. Sleep disorders are commonly overlooked as is chronic sinusitis, a fatigue-producing condition that should respond to proper therapy.
Mental fatigue in individuals with psychiatric disorders: a scoping review
Published in International Journal of Psychiatry in Clinical Practice, 2023
Kristina Mozuraityte, Agne Stanyte, Naomi A. Fineberg, Alessandro Serretti, Julija Gecaite-Stonciene, Julius Burkauskas
Mental fatigue reflects a psychobiological state characterised by subjective feelings of tiredness and lack of motivation (Herlambang et al., 2019; Lorist, 2008; Morris & Christie, 2020; van Cutsem et al., 2017), alongside poor cognitive and behavioural performance leading to diminished attention and concentration (Boksem et al., 2005; de Raaf et al., 2013; Guo et al., 2016; Morris & Christie, 2020), poor executive planning (Lorist et al., 2000; Qi et al., 2019) and difficulties focussing on the task at hand (Boksem & Tops, 2008). It can be differentiated from other recognised forms of fatigue by key aspects of its symptom-profile. Thus, unlike mental fatigue, physical fatigue is characterised as a decrease in physical performance due to physical inability to maintain the required level of strength (Abd-Elfattah et al., 2015) and social fatigue by increased withdrawal from social relationships (Nagy et al., 2018).
Fatigue in ANCA-associated vasculitis (AAV) and systemic sclerosis (SSc): similarities with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A critical review of the literature
Published in Expert Review of Clinical Immunology, 2022
Charmaine van Eeden, Mohammed S. Osman, Jan Willem Cohen Tervaert
Fatigue is a common symptom and is estimated to affect approximately 50% of the people at any given time [18,19]. However, ME/CFS in the general population is uncommon and its prevalence is estimated to be < 3% [18,20]. The etiology of ME/CFS is multifactorial and is thought to stem from immune dysregulation, metabolic abnormalities associated with certain genetic predispositions [18,21]. The diagnosis of ME/CFS is primarily based on patient-reported symptoms and clinical manifestations, with no definitive physical biomarkers or laboratory tests [22]. ME/CFS remains to be one of the largest challenges faced by numerous patients [18,20,23] with associated loss of income, sleep disturbance, and concomitant mental health complications. The connection between inflammatory disease and ME/CFS is an emerging area of interest [24–26]. Close attention has been brought to ME/CFS-like syndromes – particularly as many patients infected with SARS-CoV-2 [27], subsequently developed long COVID-19 syndrome. This development has re-invigorated research into this area with nearly 100 million US dollars in research investments recently [28]. In this review, we aim to link ME/CFS with the dysregulated mechanisms in AAV and SSc to potentially identify overlapping pathways in their pathogenesis (Figure 1). We also aim to critically summarize the clinical data describing ME/CFS in these patient groups.
Inpatient rehabilitation outcomes in neoplastic spinal cord compression vs. traumatic spinal cord injury
Published in The Journal of Spinal Cord Medicine, 2022
Sevgi Ikbali Afsar, Sacide Nur Saraçgil Cosar, Oya Umit Yemişçi, Hüma Bölük
In a study by Santos et al., no significant correlation was found between the presence of medical comorbid disease and the functional gain of patients with metastatic spinal cord compression.19 Similarly, in the current study, no statistically significant correlation was found between the FIM and FAS scores and comorbid diseases of hypertension, diabetes mellitus and coronary artery disease in the traumatic and neoplastic groups. In addition to systemic comorbid diseases, it is important to distinguish medical comorbidities associated with cancer diagnosis. Cancer-related fatigue is the most prevalent symptom experienced by individuals with cancer. With evaluation and appropriate treatment of organic factors, such as anemia and infection, are often easily correctable. However, other causes of fatigue must be considered, such as depression, and sedation caused by centrally acting drugs and pain medications.16 These patients may require supportive care and modifications of the rehabilitation care plan.18