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Instruments and Machines
Published in Qais Hooti, Sung-Hoo Hong, Minimally Invasive Urologic Surgery, 2023
Surgicel is made of oxidized cellulose polymer and manufactured by Ethicon. It is absorbable and can be cut to small sizes appropriate to cover the bleeding area.
Industrial Applications
Published in Vlado Valković, Low Energy Particle Accelerator-Based Technologies and Their Applications, 2022
The irradiation of pulp is of interest from different perspectives. Mainly it is required when a modification of cellulose is needed. Irradiation could bring many advantages, such as chemical savings and, therefore, cost savings and a reduction in environmental pollutants. In the work by Henniges et al. (2013), pulp and dissociated celluloses were analyzed before and after irradiation by EB. The focus of the analysis was the oxidation of hydroxyl groups to carbonyl and carboxyl groups in pulp and the degradation of cellulose causing a decrease in molar mass. For that purpose, the samples were labeled with a selective fluorescence marker and analyzed by gel permeation chromatography (GPC) coupled with multi-angle laser light scattering (MALLS), refractive index (RI), and fluorescence detectors. Degradation of the analyzed substrates was the predominant result of the irradiation; however, in the microcrystalline samples, oxidized cellulose functionalities were introduced along the cellulose chain, making this substrate suitable for further chemical modification (Henniges et al. 2013).
Developmental Diseases of the Nervous System
Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020
James H. Tonsgard, Nikolas Mata-Machado
Skin: Topical agents: oxidized cellulose applied to lesion.Laser ablation.
Surgicel mimicking recurrent pelvic neuroblastoma in a 3-year-old boy
Published in Acta Chirurgica Belgica, 2022
Zafer Turkyilmaz, Ramazan Karabulut, Cem Kaya, Deniz Gökce, Elif Kolay, Kaan Sonmez
Although Surgicel is accepted as absorbent, it lowers the pH in the area where it is used. Although this low pH is antimicrobial for various organisms, it stimulates inflammation in surrounding tissues and delays wound healing due to its acidic character [2]. In an experimental study, it has not been shown that hemostatic agents such as oxidized cellulose cause a granulomatous reaction such as bone wax [9]. Although surgeons think that the material will be absorbed and lost after the use of Surgicel, the complicated degradation reactions of this material include injury, blood-material interactions, temporary matrix formation, acute or chronic inflammation, granulation tissue development, foreign body reactions and fibrous capsule development [10]. It has also been reported that the Surgicel, used in thoracotomy, passes through the intervertebral foramen and exerts spinal cord compression [11].
Pulmonary toxicity and RNA sequencing analyses of mouse in response to exposure to cellulose nanofibrils
Published in Inhalation Toxicology, 2020
Li-Ying Song, Yun-Zhou Wu, Xi-Xiang Pei, Rui Li, Hai-Tao Chen, Xiao-Zheng Sun
CNFs were prepared by multi-site regioselective oxidation of cellulose with TEMPO and periodate at room temperature (20–25 °C) (Sun et al. 2018). TEMPO (0.39 g, 2.5 mmol), sodium periodate (2.14 g, 10.0 mmol), and sodium bromide (4.12 g, 40 mmol) were dissolved in distilled water (500 mL) with vigorous stirring. Microcrystalline cellulose (5 g) was then suspended in the reaction mixture. The reaction beaker was covered with aluminum foil to prevent the photo-induced decomposition of periodate. NaClO solution (10%, 2.7 mL, 40 mmol) was added slowly to the cellulose slurry with continuous stirring, and the resulting suspension was stirred at room temperature for 9 h. The pH of the suspension was carefully maintained at about 10.5 through the addition of 2 M aqueous NaOH. After the designated time, the oxidation reaction was terminated through the addition of ethanol (5 mL). The reaction slurry was centrifuged at 900 g for 2 min (TD5B, Changsha Yingtai Instrument Co. Ltd., Changsha, China), the supernatant was precipitated with ethanol, and the formed precipitate was collected by centrifugation. The oxidized cellulose was then washed and centrifuged several times with 95% ethanol and 0.5 M aqueous HCl. Finally, the precipitate was dispersed in water, collected by vacuum filtration, and the solid fraction was dried by vacuum freeze-drying. The powder obtained in this manner was analyzed as described below.
Use of Hemostatic Nasal Plugs in Emergency Medical Services in the Netherlands: A Prospective Study of 33 Cases
Published in Prehospital Emergency Care, 2018
Ruben te Grotenhuis, Pierre M. van Grunsven, Wim M.J.M. Heutz, Edward C.T.H. Tan
One of the available nasal tampons is HemCon® Nasal Plug (Figure 1), a 48 mm × 12 mm compressed sponge produced by HemCon Medical Technologies, Inc. (Portland, Oregon, USA). The sponge is made of polyvinyl alcohol, which expands on contact with fluid. The plug will swell and fill the nasal cavity, applying pressure over the bleeding point. Furthermore, the plugs are impregnated with a micro-disparted oxidized cellulose (m·doc™) derived from natural cotton. This oxidized cellulose absorbs water and forms a gel-like layer of the wound, which reduces bleeding and in theory forms a barrier to bacteria. It also provides a negatively-charged surface, which activates the intrinsic pathway of blood coagulation.11