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Endocrine Disorders, Contraception, and Hormone Therapy during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Nandrolone is an androgenic and anabolic steroid administered parenterally to treat metastatic breast cancer. Illicitly, it is used to increase muscle mass and enhance athletic performance. No studies have been published that have analyzed congenital anomalies among infants born to women treated with nandrolone during pregnancy. However, the strong androgenic action of this agent would be expected to cause virilization of the external genitalia in female fetuses. Intrauterine deaths were increased in frequency among rats born to mothers who were given up to twice the medically administered dose (Naqvi and Warren, 1971).
Rehabilitation after fracture
Published in Charles M Court-Brown, Margaret M McQueen, Marc F Swiontkowski, David Ring, Susan M Friedman, Andrew D Duckworth, Musculoskeletal Trauma in the Elderly, 2016
In addition to nutritional supplementation, some investigators have evaluated the use of anabolic agents to improve function after fracture. In older female hip fracture patients, Hedstrom et al. found that 12 months of treatment with the anabolic steroid nandrolone in concert with vitamin D and calcium resulted in maintenance of muscle mass, less bone loss and improved gait speed as compared to treatment with calcium alone.21 A more recent trial in underweight women with hip fractures did not note any additional improvement in bone mineral density in subjects receiving nandro-lone in addition to protein supplementation.22 However, a recent Cochrane review noted methodological deficiencies with the few reported studies evaluating anabolic steroids in hip fracture patients and found insufficient data to make any conclusions regarding this intervention.23 While these interventions remain investigational, there is significant interest in hip fracture patients, in particular, as a target population for newer myoanabolics due to the substantial morbidity and mortality of this condition.24
Introduction
Published in Linda M. Castell, Samantha J. Stear (Nottingham), Louise M. Burke, Nutritional Supplements in Sport, Exercise and Health, 2015
Samantha J. Stear, Hans Braun, Kevin Currell
Following a wave of Nandrolone findings in doping offences in the late 90s, several studies have sought to explore the extent of supplement contamination. These studies have shown that many DS are mislabelled or do not reflect the true ingredients, demonstrating insufficient quality control in the production process. Therefore, concern was raised regarding the potential for contamination from doping substances that were not declared on the label but would lead to a positive doping test.
Nutritional management of a polytrauma patient in an intensive care unit
Published in South African Journal of Clinical Nutrition, 2021
Recovery from an ICU stay may extend for months after discharge as catabolism prevails.7 Although the causes of ICU-associated weakness are multifactorial, the use of anabolic medications, along with suitable nutritional support and exercise, may facilitate functional improvements and better quality of life.7,12 ICU patients have been found to be testosterone depleted by day 7.7 Research on the beneficial effects of these drugs has, until recently, largely pertained to burns injuries. However, the GAINS trial in Australia, a placebo-controlled, randomised trial, investigated the effect of nandrolone, an anabolic steroid, on various markers of strength, including grip strength, in weak adult ICU patients.12 The nandrolone group had better grip strength and functional activity scores than the placebo group, although the results were not significant. No harmful effects of nandrolone were reported, and further research is warranted.12
The therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat model
Published in British Journal of Neurosurgery, 2020
Mehmet Fatih Korkmaz, Hakan Parlakpinar, Mehmet Nuri Erdem, Mehmet Fethi Ceylan, Levent Ediz, Emine Samdanci, Ersoy Kekilli
Sun et al. reported a reduction in distal femoral and proximal tibial BMD of 25% and 16%, respectively, at 56 days in rats with spinal cord injury.29 Using dual-energy X-ray absorptiometry, Jiang et al. reported that bone loss in rats with spinal cord injury was 11.5% at Day 21.30 A different study found 8.4% of bone loss in rats with chronic constriction injury of the sciatic nerve at Week 5.1 Cardozo et al. the protective effect of nandrolone against loss and slow muscle atrophy following nerve transaction and reported 7% and 12% reductions in BMD of the femur and tibia on the 28th and 56th days, respectively.28 In the present study, injured femoral diaphysis BMD was reduced significantly at the 42nd day following injury (p = 0.005).
Personal and psychosocial factors associated with anabolic-androgenic steroid use among Iranian male bodybuilders
Published in Journal of Substance Use, 2018
Mohammad Hassan Saati Asr, Saeed Bashirian, Rashid Heidari Moghadam, Majid Barati, Babak Moeini
The dominant pattern of steroid use among participants in this study included the combined use of steroids (13.2%), which is consistent with the results of the study conducted by Shoshtarizadeh et al. (2013). However, in their study, Zakeri (2012) and Atarodi & Rohani (2012) showed that Nandrolone had been reported as the most popular steroid (Piacentino et al., 2015). Obviously, different training approaches of coaches and access to different steroids are effective in shaping bodybuilders’ consumption pattern. In this study, 69.3% of bodybuilders used various nutritional supplements, which are consistent with other similar studies (Narimani, Ahadi, Boboli, & Ghadimi, 2013). It seems that the lack of close monitoring of the production process of food supplements increases the likelihood that harmful substances will be added to these food supplements, which can be associated with complications for consumers of these supplements. This issue indicates the necessity of being paid more attention by the health authorities and supervisors (Rashidlamir et al., 2014).