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Osteoporosis
Published in Charles Theisler, Adjuvant Medical Care, 2023
Chronic pain and depression are not uncommon accompanying symptoms. Decreased bone mass can also weaken spinal vertebrae to the extent that there is lost height and the development of a kyphosis, or dowager's hump, which is an abnormal curving and twisting of the thoracic spine that gives a hunched-over appearance. Osteoporosis may significantly limit mobility and may require long-term nursing home care. The goals in treating osteoporosis include lowering the risk of fractures and preventing disabilities related to osteoporosis.
Bones and fractures
Published in Henry J. Woodford, Essential Geriatrics, 2022
Osteoporosis is usually managed with a combination of non-pharmacological and pharmacological interventions. Osteopenia is usually managed by non-pharmacological measures alone. Information about the potential risks and benefits of any strategy help inform a shared decision-making process. Individualised assessments should focus on relevant clinical outcomes, rather than T-scores alone.31 The aim is for patient agreement to help promote optimal adherence. Visual decision aids are available to assist.32
Introduction to dermatological treatment
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
To prevent osteoporosis give lifestyle advice – regular exercise, stop smoking, reduce alcohol intake. Start the patient on Calcichew D3 forte, 2 tablets a day. Patients over the age of 45 (or postmenopausal women) or at risk of osteoporosis should also be on a bisphosphonate to reduce bone turnover, e.g. alendronate (Fosamax) 70 mg/week. If intolerant to this (or there are contraindications to this drug) alternatives should be discussed with a rheumatologist.
Gaps in evidence on treatment of male osteoporosis: a Research Agenda
Published in The Aging Male, 2023
Adam J. Rose, Susan L. Greenspan, Guneet K. Jasuja
However, there are many knowledge gaps about treating osteoporosis among men. There are preventive recommendations for any person who has been diagnosed with osteoporosis, such as taking appropriate calcium and vitamin D, ruling-out specific causes of secondary bone loss like hyperparathyroidism, smoking cessation, active lifestyle, and interventions to minimize fall risk. There are also promising approaches to prevent osteoporosis, such as increased weight-bearing exercise, most of which would require lifestyle changes from a much younger age. But once someone has been diagnosed with osteoporosis, beyond the basic lifestyle interventions, what treatment can be offered to them, and how effective is it? Our answers to these questions, for a male, are still largely unknown. The purpose of this review is to clarify what we don’t know, which will help set an agenda for what can be done to fill in these knowledge gaps.
Closing the gap in osteoporosis management: the critical role of primary care in bone health
Published in Current Medical Research and Opinion, 2023
Andrea J. Singer, Anita Sharma, Cynthia Deignan, Liesbeth Borgermans
Due to the growing size of the aging population globally, osteoporosis represents an increasing societal and economic burden that warrants the attention of primary care. Osteoporotic fractures are associated with high rates of disability, loss of independence, reduced quality of life for patients and caregivers, and high costs to individuals and healthcare systems. Osteoporosis is currently underdiagnosed and undertreated. As the primary contact with patients, PCPs are uniquely positioned to play a critical role in improving osteoporosis management and closing the treatment gap. We recommend that PCPs adopt a systematic approach of proactively screening patients to identify those at risk for osteoporosis and implement individualized treatment plans and follow-up to reduce the likelihood of debilitating osteoporotic fractures. This requires PCPs to gain knowledge of osteoporosis risk factors and understand the role of BMD testing and application of risk assessment tools to best treat and serve their patients. PCPs may also need to work as part of multidisciplinary teams with other medical specialties, including working groups, to offer outreach, case finding, treatment, referral, and health education. The simple strategy presented in this article can be used to guide PCPs in making decisions regarding the course of action when managing patients at risk for osteoporosis and osteoporotic fracture within the primary care setting.
Association between LEPR polymorphism and susceptibility of osteoporosis in Chinese Mulao people
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2022
Guangbin Ye, Yandong Huang, Lianfei Yin, Jianchu Wang, Xiufeng Huang, Xiaoyun Bin
This study found that BMD of the senior and middle-aged Mulao ethnic group in China decreases with age. The minority of OP in Mulao people was similar to the average of China. The decrease of BMD of men (significantly decreased after 75) was more later and slowly than that of women (significantly decreased after 55) in Mulao ethnic group. Advocating a healthy lifestyle, active intervention and early diagnosis and treatment are of great significance for the prevention and treatment of osteoporosis. The polymorphism of rs1137100, rs2767485, and rs465555 in LEPR was associated with BMD in Mulao people, and AA, CT, TT GG type were the susceptible genotypes of OP. Four haplotypes were constructed, among which, AACGCT and GGTGTA could increase the risk of OP, whereas GGCGTA might reduce OP susceptibility.