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The Role of Plant-Based Natural Compounds in Inflammation
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Marcela Dvorakova, Premysl Landa, Lenka Langhansova
Similar results were obtained in other studies. For example, Li et al. (2008) reported luteolin as inactive in COXs inhibition, while its glucoside showed extremely weak inhibition of COX-1 (IC50 = 92.3 µM), as well as of COX-2 (IC50 = 39.1 µM) (Li et al., 2008). In the study of Lee and Kim (2010), luteolin was found inactive on COX-1, while it inhibited COX-2 with an IC50 of 59.9 µM. In the same study, myricetin was found inactive and quercetin showed extremely weak inhibition (IC50 = 81.1 and 72.3 µM for COX-1 and COX-2, respectively) (Lee and Kim, 2010). Moreover, Bai and Zhu (2010) observed the stimulatory effect of myricetin and quercetin on COXs in animal studies. Oxyflavone myricitrin (3-O-α-L-rhamnopyranoside of myricetin) was reported to inhibit 5-LOX in a cell-free system with an IC50 of 7.8 µM, while it did not inhibit mPGES-1 (Winekenstadde et al., 2015). In addition, it was also not able to inhibit COXs (Noreen et al., 1998).
Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Myricetin, structurally related to kaempferol and quercetin, exhibits a wide range of bioactivities such as antiviral, anticancer, anti-inflammatory, and anti-oxidant properties. Myricetin is reported to regulate the viral enzymes of HIV, Coronavirus, and Rauscher murine leukaemia virus. It is also a potent anticancer agent since it inhibits the enzymes responsible for various types of cancer, like skin cancer, colorectal cancer, and hepatic cancer (Semwal et al. 2016).
Identification of Botanical and Geographical Origins of Honey-Based on Polyphenols
Published in Megh R. Goyal, Arijit Nath, Rasul Hafiz Ansar Suleria, Plant-Based Functional Foods and Phytochemicals, 2021
Zsanett Bodor, Csilla Benedek, Zoltan Kovacs, John-Lewis Zinia Zaukuu
Spanish researchers quantified some phenolic compounds and flavonoids (such as: myricetin, caffeic acid pinocembrin, hesperetin, naringenin, chrysin, kaempferol, quercetin, p-coumaric-acid, and galangin) by HPLC-diode array detector (DAD) method for four types of honeys. Hesperetin was detected as an exclusive marker molecule for citrus honeys. Principal component evaluation showed that kaempferol, chrysin, pinocembrin, naringenin, and caffeic acid content of rosemary honeys contributed to a separation of this honey from the other types. The relatively higher content of myricetin, quercetin. p-coumaric acid and galanginin honeydew honeys provided their separation from rosemary, citrus, and polyfloral honeys [28].
The seamless integration of dietary plant-derived natural flavonoids and gut microbiota may ameliorate non-alcoholic fatty liver disease: a network pharmacology analysis
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2023
Ki-Kwang Oh, Haripriya Gupta, Raja Ganesan, Satya Priya Sharma, Sung-Min Won, Jin-Ju Jeong, Su-Been Lee, Min-Gi Cha, Goo-Hyun Kwon, Min-Kyo Jeong, Byeong-Hyun Min, Ji-Ye Hyun, Jung-A Eom, Hee-Jin Park, Sang-Jun Yoon, Mi-Ran Choi, Dong Joon Kim, Ki-Tae Suk
Both luteolin and myricetin are secondary metabolites in natural resources or postbiotics in specific GM. The luteolin improves sensitivity level of insulin as an antidiabetic agent, including antioxidant and anti-inflammatory properties [50]. Likewise, myricetin has not only potent stimulatory effect of insulin, but accelerates lipogenesis in rat adipocytes [51]. The MK-2206 as an AKT inhibitor reached at a phase II clinical trial suppressed the progression of NAFLD [52]. Uncommonly, there was no relationship between CFTR and hepatic steatosis in the development of NAFLD [53]. Wortmannin as PIK3R1 (PI3K) inhibitor diminished the expression level of interleukin 1β (IL-1β) and interleukin 18 (IL-18), which leads to protecting mice from NAFLD [54]. The results suggested that targets (AKT1, PIK3R1) and effectors (luteolin, myricetin) might be critical elements to alleviate NAFLD on a pharmacological viewpoint. Thus, our innovative methodology gives significant clues to clarify the nuanced relationships between GM and DPDNFs.
Modulation of mitochondrial permeability transition pore opening by Myricetin and prediction of its-drug-like potential using in silico approach
Published in Drug and Chemical Toxicology, 2023
Akinwunmi O. Adeoye, John A. Falode, Olabimpe C. Oladipupo, Tajudeen O. Obafemi, Babatunde J. Oso, Ige F. Olaoye
Flavonoids represent a collection of phytochemicals that are largely distributed in various plants in rather high quantities. They have been substantiated to be ideal natural antioxidant compositions in many common plants and herbs (Sartor et al. 2002, Li et al. 2011). Myricetin, a natural flavonoid has attracted great interest due to its antioxidant and free-radical scavenging activities. It is widely distributed in natural plants (Deepak et al. 2016, Bridi et al. 2019, Nardini and Garaguso 2020), as an important active ingredient and additive in many foods. Myricetin has also shown a therapeutic effect on many diseases, including tumors of different types, inflammatory diseases, thrombosis, cerebral ischemia, atherosclerosis, diabetes, and Alzheimer’s disease (Song et al. 2021). Various studies had been reported using computational approaches in investigating putative compounds that could be repurposed or repositioned as drugs. This study, investigated the effects of myricetin on mitochondria permeability transition pores in vitro and also its inhibitory potential on proteins that are important in the apoptotic process in silico.
Development and formulation of antidiabetic property of Anarcadium occidantale-based solid lipid microparticles
Published in Journal of Microencapsulation, 2022
Kingsley C. Eze, Calister E. Ugwu, Fimber S. Odo, George C. Njoku
According to Den Hartogh and Tsiani, naringenin inhibits glucose absorption as well as renal glucose reabsorption, thereby reducing diabetic hyperglycemia (Den Hartogh and Tsiani 2019). Kaempferol has been shown to improve insulin sensitivity, thereby protecting against pancreatic β-cell dysfunction (Alkhalidy et al. 2015). Myricetin, on the other hand, was found to increase glycogen synthase 1 activity in diabetic hepatocytes and improve insulin sensitivity (Li et al. 2017), whereas quercetin inhibited intestinal glucose absorption, insulin secretory and insulin-sensitizing activities, and improved glucose utilisation in peripheral tissues (Eid and Haddad 2017). Procatechuic acid, a phenolic glycoside, suppresses diabetic cardiomyopathy by stimulating glucose metabolism, alleviating oxidative stress, and inhibiting inflammation (Bhattacharjee et al. 2017).