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Nutritional and Medicinal Benefits of Ficus carica
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Luteolin emerged to be the principal flavonoid in the ficus leaf , representing a somewhat greater content of flavonoids as compared to quercetin. Luteolin is thought to have the probability of playing a considerable role in health, as it is considered to show wide-ranging anti-inflammatory effects (Jang et al., 2008), along with immunomodulatory, antioxidant, antimicrobial and anticarcinogenic activities. Inflammation, hypertension, cancer and several other diseases have been managed by using food enriched with luteolin in the traditional medicinal system (Lin et al., 2008). Gas chromatography/ion trap mass recognised around seven plant sterols from the ficus latex extract. They are analysed with the help of HPLC combined with HPLC-DAD (diode array detection). The quantities of α-amyrin, β-sitosterol, β-amyrin, lupeol acetate, lanosterol, lupeol and betulol were 76, 10,564, 1,197, 1,989, 2,634, 2,827 and 327 mg/kg of the latex of plant, correspondingly. Hence, β-sitosterol is the constituent found in maximum quantities while α-amyrin is the slighter one (Shiraishi, 1996).
COVID-19 Pandemic and Traditional Chinese Medicines
Published in Hanadi Talal Ahmedah, Muhammad Riaz, Sagheer Ahmed, Marius Alexandru Moga, The Covid-19 Pandemic, 2023
Roheena Abdullah, Ayesha Toor, Hina Qaiser, Afshan Kaleem, Mehwish Iqtedar, Tehreema Iftikhar, Muhammad Riaz, Dou Deqiang
Luteolin is a natural flavonoid that inhibits proliferation of tumor cells and is also anti-inflammatory and anti-oxidant in nature. With EC50 of 10.6 μmol/l, luteolin proved to be effective for inhibition of cleavage activity of SARS-CoV and at EC50 of 20.2 μmol/l, it can inhibit SARS-CoV 3C like protease activity. Molecular docking has shown strong interaction of Luteolin with SARS-CoV-2 via 3C like protease, RdRp, P like protease, and Spro [24].
Nutrition Part I
Published in Mark C Houston, The Truth About Heart Disease, 2023
Several dietary and nutritional components have been shown to decrease inflammation by interrupting the inflammatory vascular receptors (8). These include the following:Curcumin (turmeric).Cinnamaldehyde (cinnamon).Sulforaphane (broccoli).Resveratrol (nutritional supplement, red wine, grapes).Epigallocatechin gallate (EGCG) (green tea).Luteolin (celery, green pepper, rosemary, carrots, oregano, oranges, olives).Quercetin (tea, apples, onion, tomatoes, capers).
Enhancement of oral bioavailability and anti-colitis effect of luteolin-loaded polymer micelles with RA (rosmarinic acid)-SS-mPEG as carrier
Published in Drug Development and Industrial Pharmacy, 2023
Zhaomin Lu, Juan Liu, Liangjian Zhao, Chenli Wang, Feng Shi, Zhengqi Li, Xuesong Liu, Zhiwei Miao
Luteolin (3, 4, 5, 7-tetrahydroxyflavone) is a known flavonoid compound, which is usually isolated from celery, honeysuckle, balsam and other plants [10]. Luteolin possesses several biological properties, namely anti-inflammatory, antibacterial, antioxidant, anti-cancer and cytoprotective effects [11]. The potential of luteolin to inhibit pro-inflammatory factors (like TNF-α) secretion in mouse macrophages has been described by Li et al. [11]. Also, luteolin could suppress proliferation of cells and regulation of HCT-15 (human) colon cancer cells through regulation of wnt/β/catenin signaling pathway [12]. Additionally, in vivo experiment showed that luteolin had a protective effect on interleukin-10 (IL-10) deficient mice in an experimental colitic model [13]. Luteolin could also inhibit azoxymethane-induced colon cancer in mice through Nrf2 pathway interference [14]. Despite these wide health benefits, the clinical application of luteolin is limited because of its low water solubility. Therefore, it is necessary to improve its solubility in water to promote its development and application further.
Exacerbation of diclofenac-induced gastroenterohepatic damage by concomitant exposure to sodium fluoride in rats: protective role of luteolin
Published in Drug and Chemical Toxicology, 2022
Akinleye S. Akinrinde, Kehinde O. Soetan, Monsuru O. Tijani
Taken together, exposure of rats to diclofenac resulted in significant gastroenterohepatic damage, as evidenced by the macroscopic and microscopic lesions seen as well as the results of the examination of the rats, in accordance with the biochemical parameters of oxidative stress, particularly in the gastric and duodenal tissues, and to a lesser extent, in the liver. An important finding in this study was that these alterations were significantly exacerbated in rats that were treated concomitantly with sodium fluoride. The data from this study suggests that formulations combining the concurrent use of these compounds must be administered with caution, because of potential interactions that may aggravate gastrointestinal damage. The gross and histologic manifestations of gastrointestinal injury may be partly explained by the alterations observed in the oxidative status of the tissues. However, there is a need for future studies to investigate underlying molecular mechanisms involved in the process. The flavonoid, Luteolin, was studied and its protective influence against diclofenac and sodium fluoride-induced injury was documented. This influence may be attributed to its antioxidant and/or anti-inflammatory activities. Based on the findings of the study, Luteolin may thus be considered an important agent for the amelioration of gastrointestinal and hepatic damage elicited by combined administration of gastrointestinal toxicants such as diclofenac and sodium fluoride.
Luteolin Induces Apoptosis and Autophagy in HCT116 Colon Cancer Cells via p53-Dependent Pathway
Published in Nutrition and Cancer, 2022
Ho Soo Yoo, Sae Bom Won, Young Hye Kwon
In the European Union, the average daily intake of luteolin was approximately 1 mg in 18 to 64 years of adults. Similarly, luteolin intake of 3.82 mg/day was reported in Chinese adult group study (Del Bo et al. 2019). In ninety-two Chinese students, strong positive correlations were observed between dietary intake of flavonoids, including apigenin and luteolin, and their plasma concentrations when plasma flavonoids were determined after enzymatic hydrolysis. The mean dietary intake of luteolin was 8.08 mg/d and the corresponding mean plasma concentration was 99.90 nM (Cao et al. 2010). In human study with oral administration of artichoke leaf extracts with luteolin glycosides equivalents to 14.4 mg luteolin, maximum observed plasma concentration was about 200 nM at 0.36 h after intervention. Free luteolin in plasma or urine was detected after enzymatic hydrolysis of conjugates (Wittemer et al. 2005), implicating low systemic bioavailability of free luteolin.