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Total Body Neutron Activation
Published in Stanton H. Cohn, Non-Invasive Measurements of Bone Mass and Their Clinical Application, 2020
A study of the efficacy of methandrostenolone46 showed significant differences (p≤0.001) in TBCa between treated and control groups. TBCa increased 2% in the treated group and decreased 3% in the placebo group. These data strongly suggest that long term (26 months) use of methandrostenolone in postmenopausal women prevented bone loss; the possibility that a significant increase in bone mass above initial values occured is less certain.
Medical Consequences of Anabolic Steroids
Published in John Brick, Handbook of the Medical Consequences of Alcohol and Drug Abuse, 2012
James Langenbucher, Thomas Hildebrandt, Sasha J. Carr
Most of the anabolics were developed and manufactured by JEV Jenapharm (Jena, Germany), adapting technical expertise from the Schott-Zeiss Institute for Microbiology at the University of Jena. Much of the program was concentrated around the daily administration of 0.125 mg per kilo of bodyweight of an oral steroid, Turinabol, a close relative of methandrostenolone was first produced by Jenapharm in 1961. The drug was administered in five annual blocks or “cycles” of four to six weeks duration. Injectible anabolics, too, were administered, but for some reason have not been as widely discussed. The DDR program was astonishingly successful. An East German steroid-fueled national sports federation captured 181 Olympic medals 1968-1976, including 90 in the Montreal games alone, transforming a small country into an athletics powerhouse that consistently rivaled both the United States and the Soviet Union for medal supremacy. Some of the abuses of the DDR anabolic-sports federation have been revealed in formerly secret documents (Franke and Berendonk, 1997), and numerous DDR officials have faced both civil and criminal penalties for providing “vitamin cocktails” to naïve female adolescents whose deep voices, broad shoulders, and masculine-level power intimidated and amazed their international competition.
Acute pancreatitis secondary to the use of the anabolic steroid trenbolone acetate
Published in Clinical Toxicology, 2019
Vidhya Kumar, Danny Issa, George Smallfield, Doumit Bouhaidar
We report a case of AP induced by an anabolic steroid, trenbolone acetate (TA). TA is licensed in the United States as a growth promoter in the live stock industry [7], but not licensed for human use and is frequently used illegally in the bodybuilder community for muscle growth. Supply of anabolic steroids are easily found on online sources without a prescription [8] and supplied by unregulated international pharmacies with disclaimers that consumers are subject to local laws. In addition to online access, many athletes have obtained the steroids from friends, gym members or training partners [9,10]. Our patient was a 24-year-old male who presented with AP. He had suffered three previous episodes of recurrent AP following administration of TA - the re-challenge resulting in AP each time. Other case reports link anabolic steroids to AP [10,11], such as a case involving androgenic anabolic steroids such as “Guerilla Warfare” which contains Trenaavar, Promagnon and Ment Dione, and an additional case with chronic use of methandrostenolone (Dianabol). Treatment in both of these cases consisted of supportive care, including intravenous fluid resuscitation, appropriate pain management, and pancreatic rest with slow introduction of oral nutrition [10,11].
The role of hormones in muscle hypertrophy
Published in The Physician and Sportsmedicine, 2018
Julius Fink, Brad Jon Schoenfeld, Koichi Nakazato
The major AAS used by athletes can be divided into three groups [30]: Testosterone derivatives (T, Methyltestosterone, Methandrostenolone, Chlorodehydromethyltestosterone, Fluoxymesterone, Boldenone): The compounds in this group are known to induce fast strength and muscle gains but show a high rate of aromatization. Due to the high water retention caused by aromatization, they are mainly used in bulking cycles for quick mass gains.Dihydrotestosterone derivatives (Stanozolol, Oxandrolone, Oxymetholone, Mesterolone, Methenolone, Drostanolone): Even though most of these compounds are highly androgenic, they have a high binding affinity to the androgen receptor and are potent strength and muscle mass builders. Due to the DHT structure, these compounds cannot aromatize to estrogen. Therefore, these compounds are often used for cutting cycles and pre-contest.Nandrolone derivatives (Nandrolone, Trenbolone): Compounds in this group show the highest anabolic to androgenic ratio and have strong muscle building effects. However, administration of nandrolone derivatives can result in elevated progestogenic activity. The use of this group of AAS is versatile and is used for both bulking and cutting cycles.