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Phytotherapeutic Agents in Epilepsy
Published in Vikas Kumar, Addepalli Veeranjaneyulu, Herbs for Diabetes and Neurological Disease Management, 2018
Imperatorin is a furocoumarin isolated from Urena lobata L. (Fam. Malvaceae). Several studies have have shown the anticonvulsant potential of this compound. A comparative study relating to anticonvulsant effects of imperatorin and osthole in MES seizure test in mice concluded that the two furocoumarins caused suppression of seizures, quite similar to the classical antiepileptic drug valproate.156 Imperatorin has been reported to enhance the protective activity of conventional antiepileptic drugs against MES-induced seizures by Luszczki et al. in 2007 and they have also studied the time-course and dose response relationships of imperatorin in the MES model.157–159
Inhibiting the Absorption of Dietary Carbohydrates and Fats with Natural Products
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Defatted ethanol extract of aerial parts of Ducrosia anethifolia DC. at a concentration of 10 μg/mL inhibited in vitro α-amylase and α-glucosidase by 31.2% and 28.8%, respectively (acarbose 10 μg/mL: 32.2% and 29.9%, respectively).140 From this extract, imperatorin (Figure 1.34) at a concentration of 10 μg/mL inhibited in vitro α-amylase and α-glucosidase by 28.2% and 28.8%, respectively.140 The extract given orally to streptozotocin-induced diabetic rats (fasting blood glucose >300 mg/dL) at a daily dose of 500 mg/kg for 45 days decreased glycaemia from 365 to 165.6 mg/dL (normal: 111.5 mg/dL) and ameliorated serum cholesterol and triglycerides.140 Rats with fasting blood glucose between 120 and 250 mg/dL are considered as mildly diabetic, whereas rats with a fasting blood glucose value of 300 mg/dL or more are severely diabetic.141 Severe diabetes in rats suggests massive pancreatic insults by alloxan and streptozotocin.
Alloimperatorin from Ammi majus fruits mitigates Piroxicam-provoked gastric ulcer and hepatorenal toxicity in rats via suppressing oxidative stress and apoptosis
Published in Biomarkers, 2022
Howaida I. Abd-Alla, Ghadha Ibrahim Fouad, Kawkab A. Ahmed, Kamel Shaker
Previous results on Ducrosia species displayed the high activity of furocoumarins isolated from the nonpolar extracts e.g., n-hexane and ethyl acetate extracts (Abd-Alla et al. 2016). The principal furanocoumarins including methoxsalen 2, imperatorin 5 and heraclin 3 and other coumarins of significance are isoimperatorin 4, heraclenin, and isopimpinellin (Balbaa et al. 1973; Abu-Mastafa et al. 1975; Hossain and Al Touby 2020). Imperatorin 5 and isoimperatorin 4 are the major furanocoumarins isolated from the dried root of Angelica dahuricae, the plant belongs to the same family of Ammi majus (Uto et al. 2015; Bai et al. 2021). Pharmacological and biochemical studies have indicated that heraclin 3 and isoimperatorin 4 have anti-inflammatory activity (Uto et al. 2015; Bai et al. 2021). Although evidence on other coumarinss’ related biological activities is great, it lacks information about Allo biological activities. Thereby, this study was conducted to investigate Allo’s potential activities in the liver, kidney, and gastric disorders. Another member of the 6, 7-furanocoumarin family-like alloimperatorin (6) is isoimperatorin (4), which is characterised by exerting anti-inflammatory and analgesic activities (Banikazemi et al. 2021). The anti-inflammatory properties of furocoumarins previously isolated from A. majus aerial parts (bishop’s weed) have been confirmed (Tanimoto et al. 2020). 6-hydroxy-7-methoxy coumarin and hydroxy-7-methoxy-4 methyl coumarin have shown high anti-inflammatory activity (Tanimoto et al. 2020).
Anti-nociceptive and anti-inflammatory effect of imperatorin: evidences for involvement of COX-2, iNOS, NFκB and inflammatory cytokines
Published in International Journal of Neuroscience, 2020
Gurjit Singh, Jashanpreet Kaur, Manpreet Kaur, Palwinder Singh, Rajbir Bhatti
Imperatorin also known as marmelosin is a furanocoumarin widely reported in plants of family Umbelliferae. Results from various pre-clinical studies have confirmed that imperatorin possesses numerous pharmacological activities such as anti-inflammatory, antiviral activity, anti-carcinogenic, antihypertensive, anti-convulsant and anti-anxiety [8]. Studies have also documented neuro-modulatory effect of the imperatorin and anti-inflammatory action in cell lines through decrease in inflammatory cytokines [9]. Imperatorin has also been documented to suppress calcium and voltage gated sodium channels [10] Previous studies from our laboratory have revealed that osthole, a naturally occurring coumarin inhibits the expression of COX-2 and iNOS [11]. In the current investigation, the effect of imperatorin in mouse model of pain and inflammation and possible molecular mechanism has been explored.
Antagonism of NK-1R using aprepitant suppresses inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Xiaoping Liu, Yuelan Zhu, Wei Zheng, Tangliang Qian, Haiyu Wang, Xiujuan Hou
Excessive production of proinflammatory mediators such as IL-1β, IL-6, IL-8, and TNF-α as well as the increased generation of ROS play an important role in affecting the progression and severity of RA. Blockage of oxidative stress and inflammatory responses induced by pro-inflammatory factors in synoviocytes has been considered as a potential therapeutic strategy against RA. For example, salicin has been shown to display anti-oxidant and anti-inflammatory capacities through hindering NF-κB signalling and activating Nrf2 and HO-1 in RA-FLSs [20]. Another study reported that administration of the natural product paeonol could attenuate IL-1β-induced synovial inflammation in FLS-RAs and progression of RA in mice through modulating the production of proinflammatory cytokines and activation of the TLR4/NF-κB signalling pathway [21]. Imperatorin has been reported to inhibit cell proliferation and induce apoptosis in RA-FLSs, which may be associated with mitochondrial/caspase-mediated signalling pathways [22]. TNF-α has been identified as a predominant inflammatory regulator in the pathogenesis of RA. The expression of TNF-α is greatly increased in synovial fluid in RA [23]. TNF-α stimulation in FLSs can induce a prolonged and sustained inflammatory response, leading to persistent synovial inflammation in RA [24]. Thus, disrupting the TNF-α signalling cascade in RA FLSs has been considered as an important strategy for the treatment of RA. Indeed, TNF-α inhibitors have made great advances in the management and therapy of RA [25]. In this study, we report that blockage of NK-1R using aprepitant ameliorates the TNF-α-induced inflammatory response in FLSs. Consistently, the anti-inflammatory effects of aprepitant have been reported in previous investigations. For example, antagonism of NK-1R using aprepitant has been shown to attenuate the B. burgdorferi-associated neuroinflammatory response by preventing astrocyte activation [26]. NOX-4 is involved in the release of superoxide by FLSs in response to TNF-α treatment [27]. Interestingly, we found that aprepitant treatment reduced NOX-4 expression and production of ROS, suggesting that antagonism of NK-1R may be able to mitigate oxidative stress in RA. The presence of increased expression of cytokines and upregulated expression of MMP-3 and MMP-13 in RA-FLSs leads to collagen degradation and joint inflammation in RA [6]. Our findings show that aprepitant treatment reduced the expression of MMP-3 and MMP-13, implicating that aprepitant might possess a protective effect against articular cartilage disruption in RA. TNF-α initiates the expression of pro-inflammatory genes by activating the NF-κB signalling pathway. NF-κB is a central regulator of the inflammatory response in RA-FLSs. The inhibitory effects of aprepitant in NF-κB activation suggests that aprepitant may have a wide range of anti-inflammatory capacities in FLSs.