China 
Africa 
Explore chapters and articles related to this topic
Flaxseed, a Functional Food—Constituents and Their Health Benefits
Published in Robert Fried, Richard M. Carlton, Flaxseed, 2023
Robert Fried, Richard M. Carlton
Besides lignans, other phenolic compounds found in flaxseed are p-coumaric acid and ferulic acid. P-coumaric acid is a plant metabolic by-product that exhibits antioxidant and anti-inflammatory properties. It also shows bactericidal activity by damaging bacterial cell membranes and by interacting with bacterial DNA. Ferulic acid is an antioxidant that works to boost the effects of other antioxidants. It is commonly used in skin care products to protect overall skin integrity by reducing the development of fine lines, spots and wrinkles.
Dietary Substances Not Required in Human Metabolism
Published in Luke Bucci, Nutrients as Ergogenic Aids for Sports and Exercise, 2020
Ferulic acid is a common phenolic acid found in almost every plant.852 Gamma oryzanol, a ferulate ester of sterols found in rice bran, has also been the subject of studies. Gamma oryzanol is mostly converted to ferulic acid during digestion.852 Ferulic acid closely mimics the structure of normetanephrine, the primary metabolite of norepinephrine.852 Animal studies have found that ferulate administration can mimic effects of increased hypothalamic norepinephrine,852 such as stimulation of somatotropin synthesis by the pituitary.853–855 Infusion of 100 or 500 mg of ferulic acid (0.3 mg/kg) into heifers elevated serum somatotropin levels significantly.856 Other pituitary hormones were generally not affected.852–856
Preclinical Antidepressant-Like Effects of Terpenes, Polyphenolics, and Other Non-Flavonoid Phytochemicals
Published in Scott Mendelson, Herbal Treatment of Major Depression, 2019
Ferulic acid is a phenolic compound, a derivative of cinnamic acid, that is present in a variety of food and medicinal plants, including bamboo shoots, popcorn, chocolate, coffee, red cabbage, grapefruit, eggplant, spinach, and whole grains.79 It is also a component of many medicinal plants used in Traditional Chinese Medicine for the treatment of MDD and other neurological conditions. Those include Angelica sinensis, Avena sativa, Curcuma longa, Hericium erinaceus, Ligusticum chuanxiong, and others. It has been identified as an important phytochemical constituent of the Chinese herbal combinations, chaihu shugan and xiaoyaosan that are used for MDD.
Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer’s disease
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Gaofeng Zhu, Ping Bai, Keren Wang, Jing Mi, Jing Yang, Jiaqi Hu, Yujuan Ban, Ran Xu, Rui Chen, Changning Wang, Lei Tang, Zhipei Sang
Ferulic acid (FA) is a polyphenol that is abundant in vegetables and maize bran. Several lines of evidence have displayed that FA would be hopeful for treating AD because of its scavenging free radicals, Aβ aggregation inhibition properties, anti-inflammatory properties, and neuroprotective effects13,14. However, the low bioavailability of FA limits its clinical uses in AD. Based on this, many groups have developed the FA derivative to treat AD14. Rasagiline, a selective MAO-B inhibitor, which has been approved for treating symptoms of Parkinson’s disease, is in Phase II clinical trial with mild to moderate AD, the data showed that Rasagiline improved blood flow in a separate small study of 11 people with AD treated for a median of 1.7 years with 1 mg per day, along with donepezil6. The propargyl group has been confirmed as the pharmacophore of rasagiline. In addition, evidences show that introducing benzyl derivatives and alkyl fragment into the skeleton could increase MAO-B inhibitory potency15. Thus, we plan to introduce the propargyl, benzyl, and alkyl fragment into the FA skeleton based on the MTDLs strategy and create novel O-alkyl ferulamide derivatives as multifunctional agents (Figure 2).
Intake of New Zealand Blackcurrant Powder Affects Skin-Borne Volatile Organic Compounds in Middle-Aged and Older Adults
Published in Journal of Dietary Supplements, 2022
M. E. T. Willems, M. Todaka, M. Banic, M. D. Cook, Y. Sekine
Emission of acetic acid by the skin has been associated with foot malodor (Caroprese et al. 2009) and body odor in young adults (Lam et al. 2018). The acetic acid is thought to be the result of bacterial metabolic activity that results in transformation of secretions by the eccrine glands. Cutaneous propionibacterium and staphylococcus epidermidis synthesize acetic acid (Lam et al. 2018; Piwowarek et al. 2018). Therefore, if NZBC powder inhibits activity of propionibacterium and staphylococcus epidermidis, it may affect skin health due to their role in acne (Wang et al. 2016). Interestingly, tea polyphenols are suggested to reduce sebum production in the skin and have potential for acne treatment (Saric et al. 2016). Other phenolic compounds, such as ferulic acid which is a metabolite of cyanidin-3-O-glucoside (de Ferrars et al. 2014), have been proposed as well with potential for skin disorders (Działo et al. 2016). However, we cannot exclude that reduced sebum production occurred by intake of NZBC powder.
Nephroprotective effect of ferulic acid on gentamicin-induced nephrotoxicity in female rats
Published in Drug and Chemical Toxicology, 2022
Vasfiye Erseçkin, Handan Mert, Kıvanç İrak, Serkan Yildirim, Nihat Mert
There is an ever-increasing interest in the therapeutic use of natural antioxidant compounds. Phenolics in particular are recognized as potential therapeutic agents for neurodegenerative diseases, cancer, diabetes, cardiovascular disorders, inflammatory diseases, and ageing (Soobrattee et al.2005). Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is obtained from the Ferula foetida and its name was inspired from the name of the plant (Kumar and Pruthi 2014). Ferulic acid is a phenolic acid present in the leaves and seeds of plants. It is mostly found in plants such as oats, artichokes, oranges, rice, wheat and pineapples. In recent years, high therapeutic potential of ferulic acid has attracted considerable attention in terms of research. It has been reported that ferulic acid has a wide range of potency, including anti-inflammatory, antidiabetic, anticarcinogenic, antiapoptotic, antiaging, hepatoprotective, neuroprotective, radioprotective, pulmonary protective, antiatherogenic, hypotensive, and vasodilatation effects (Middleton et al.2000, Kumar and Pruthi 2014). Ferulic acid has been determined as a powerful antioxidant that neutralizes free radicals such as nitric oxide, superoxide and hydroxyl groups that damage the DNA (Koh 2013, Mancuso and Santangelo 2014, Sung et al.2014). There have been many studies in recent years suggesting a significant protective effect for ferulic acid in kidney diseases (Manikandan et al.2014, Hasanvand et al. 2018, Sarıkaya 2018).