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Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, dimethyl-sulfoxide (DMSO), and glucosamine sulfate. Organic sulfur, as SAAs, can be used to increase synthesis of S-adenosylmethionine, glutathione, taurine, and N-acetylcysteine (14). MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Other sulfur compounds such as S-adenosylmethionine, dimethyl-sulfoxide, taurine, chondroitin sulfate, glucosamine, and reduced glutathione may also have clinical applications in the treatment of a number of ailments such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS (13). In addition, sulfur is needed for a number of chemical reactions involved in the metabolism of drugs, steroids, and xenobiotics (13). The other sulfur compounds of biological significance are thiocyanate (SCN) in saliva and other fluids, ergothioneine of the red blood cells, glutathione, present in all cells, and glucosamine and chondroitin sulfate, which serve a structural function in cartilage, bone, tendons, blood vessel walls, and so on (8).
The Use of Brain Slices in the Study of Free Radical Actions
Published in Avital Schurr, Benjamin M. Rigor, BRAIN SLICES in BASIC and CLINICAL RESEARCH, 2020
The protective properties of antioxidants and free radical scavengers add further support for a free radical mechanism underlying the actions of the generating systems used in the hippocampal slice. Dimethyl sulfoxide (DMSO) is a hydroxyl radical scavenger.43–45 It protects E/S coupling against impairment by peroxide and by dihydroxyfumarate.26,38 However, it does not protect against the decreased synaptic efficacy occurring with peroxide exposure.26 The hydroxyl radical scavenger, thiourea, is an effective protectant in many systems.3 Unfortunately, it has direct actions on electrophysiological potentials in the hippocampal slice preparation, making interpretation of the data difficult. However, it does appear to limit the damage produced by peroxide when the concentration is carefully chosen.26 Trolox C, a water-soluble vitamin E analog, is an antioxidant that protects tissue in part by scavenging peroxy radicals.3,46–48 Trolox C is very effective in hippocampal slices, limiting the consequences of exposure to hydrogen peroxide26 (Figure 2).
Interstitial cystitis and chronic pelvic pain
Published in J Kellogg Parsons, E James Wright, The Brady Urology Manual, 2019
Intravesical dimethyl sulfoxide (DMSO):49Mechanism of action is unclear45Up to 50% of patients will respond42Protocol: 50 ml once per week for 6–8 weeks42May cause significant pain flares during instillation.
Effect of Local and Systemic Dimethylsulfoxide on Peripheral Nerve Repair: A Controlled Randomized Experimental Study
Published in Journal of Investigative Surgery, 2021
Elif Sanli, Gungor Cagdas Dincel, Ebru Umay
Peripheral nerve injury causes loss of sensation and function [1], and after complete nerve transection, surgical repair is mandatory. However, surgical repair is often insufficient for sufficient functional outcome, and it causes sequelae in the patient. Dimethylsulfoxide (DMSO) is an antioxidant and anti-inflammatory agent that has been shown to protect brain tissue against the oxidative injury produced by ischemia [2]. Moreover, DMSO decreases neuronal damage due to chronic ethanol exposure [3]. This agent has also been shown to reduce oxidative damage to the brain after ischemia/reperfusion and middle-cerebral artery occlusion [4, 5]. However, the effect of DMSO on peripheral nerve injury has not been well evaluated in the literature, therefore, the present study was designed to evaluate the effectiveness of local and systemic administration of DMSO on peripheral nerve repair after neurotmesis.
Eu(III)-coordination polymer: inhibitory activity on cervical cancer via inducing ROS mediated apoptosis
Published in Drug Development and Industrial Pharmacy, 2020
Annexin V-FITC/PI apoptosis assay (BD Biosciences, San Jose, CA) was utilized to determine the HCC94 cervical cancer cells percent after combined treatment. The performance was conducted in accordance with the instruments. Briefly, in the exponential growth phase, we collected the HCC94 cervical cancer cells and then the cells were seeded into cell culture plates (2 × 105 cells/well). After incubation at the condition of 37 °C 5% humidified CO2 for 12 h, we added this compound to cells for processing at the concentration of 5 µM. 0.1% DMSO (0.1% dimethyl sulfoxide) was used as negative control and the apoptosis inducer kit (Beyotime, Shanghai, China) was used as the positive control. Next, cell was labeled using 5 µl propidium iodide (PI) and 5 µl Annexin V-FITC. Flow cytometry (BD, Franklin Lakes, NJ) was used to measure the absorbance of all samples at the emission wavelengths of 525 and 625 nm and excitation wavelength of 488 nm. The test was performed at least three times.
Propentofylline reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatase-1: An experimental study in a rat model of acute incisional pain
Published in Neurological Research, 2019
Yuanyuan Yang, Yisa Shi, Juan Jia, Shenghong Wang, Hong Chang, Mingguo Li, Xu Jin, Jing Wang
Male Sprague-Dawley healthy rats (supported by Traditional Medical University of Gansu province in China, weighing 250–300 g, 1.5–2.0 months old) were housed separately and maintained on a 12 h/12 h day and night cycle in an animal facility with free access to food and water. For the study, rats were divided into six different treatment groups. Rats in the naïve group (n = 6) received no injection. Rats in the NS group (n = 6) were injected intrathecally with 10 μL of normal saline. Rats in the DMSO group (n = 6) were injected intrathecally with 10 μL of 10% DMSO (dimethyl sulfoxide, diluted to 10% with NS). Rats in the IP group (n = 30) underwent acute paw incisional pain surgery without injection. Rats in the PPF group (n = 36) underwent acute paw incision surgery and were injected intrathecally with PPF (Sigma, 10 μg/10 μL diluted in NS) 30 minutes postoperatively. Rats in the Ro 31–8220 group (n = 6) underwent acute paw incision surgery and were injected intrathecally with Ro 31–8220 (40 μg/20 μL diluted in 10% DMSO) 30 minutes preoperatively and then with PPF (10 μg/10 μL) 30 minutes postoperatively.