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Cosmetic-Medical Treatments
Published in Paloma Tejero, Hernán Pinto, Aesthetic Treatments for the Oncology Patient, 2020
M. Lourdes Mourelle, B. N. Díaz
Vitamin B5 or D-panthenol acts like a moisturizer, improving stratum corneum hydration, reducing transepidermal water loss and maintaining skin softness and elasticity. Activation of fibroblast proliferation, which is of relevance in wound healing, has been observed both in vitro and in vivo with dexpanthenol. Accelerated reepithelization in wound healing, monitored by means of the transepidermal water loss as an indicator of the intact epidermal barrier function, has also been seen. Dexpanthenol has been shown to have an anti-inflammatory effect on experimental UV-induced erythema. The stimulation of epithelization and granulation and the mitigation of itching were the most prominent effects of formulations containing dexpanthenol; they also improved the symptoms of skin irritation, such as dryness of the skin, roughness, scaling, pruritus, erythema, and erosion/fissures, over 3–4 weeks [30]. A study of colloid gel versus dexpanthenol demonstrated the clear clinical benefit of a hydroactive colloid gel over an oil-in-water (O/W) emulsion containing 5% dexpanthenol for the prevention of radiotherapy-induced moist desquamation [31].
Scientific Rationale for the Use of Single Herb Remedies in Ayurveda
Published in D. Suresh Kumar, Ayurveda in the New Millennium, 2020
S. Ajayan, R. Ajith Kumar, Nirmal Narayanan
Several reports are available on the wound-healing property of G. glabra. Zaki et al. (2005) studied the healing effect of licorice extract on open skin wounds in adult New Zealand rabbits. Full-thickness wounds (15 × 15 mm) were made on the shaven areas of the rabbits. Creams incorporating 5%, 10% and 15% (w/w) of hydroalcohol extract were prepared and applied twice daily. Dexpanthenol ointment was used as the standard control. Healing was assessed by reduction in wound area. Results of this study proved that 10% licorice cream was a potent healing agent, showing results better than dexpanthenol cream.
Nina: The Use of Potent Opioids in a Complex Chronic Pain Patient
Published in Michael S. Margoles, Richard Weiner, Chronic PAIN, 2019
She was next seen on 12/21/94. The patient had been treated for an upper respiratory infection, and on 11/30/94 she had been instructed to add dexpanthenol injection (3 cc) twice a day for 2 days and then daily for 5 days as adjunctive treatment to the antibiotics that her local medical doctor was prescribing for her. The patient was told to buy Mineral Insurance Formula from Bronson and take three tablets per day. She had been on a generic B-complex tablet from a local drugstore and was told to discontinue that and begin nontime-release B complex with C and E by Bronson at two tablets twice per day. At that visit, her L-thyroxine was increased to 0.05 mg/day. Her B-complex injection was upgraded to the components of a half-strength shot, still minus the components indicated previously.
Dexpanthenol may protect the brain against lipopolysaccharide induced neuroinflammation via anti-oxidant action and regulating CREB/BDNF signaling
Published in Immunopharmacology and Immunotoxicology, 2022
Gülin Ozdamar Unal, Halil Asci, Yalcın Erzurumlu, Ilter Ilhan, Nursel Hasseyid, Ozlem Ozmen
Dexpanthenol (Dex, or d-panthenol; (+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3 dimethylbutyramide) is an alcoholic analog of pantothenic acid (PA). This substance has been tried in many events, such as wound healing and cosmetic conditions. In addition to this proliferative effect of the active ingredient, scientists have proven its antioxidant, anti-inflammatory, and anti-apoptotic properties with various studies [8,9]. However, in these studies, it has not been shown which intracellular mechanisms the properties mentioned above use, and their effect on learning and memory has not been investigated. In this study, we aimed to investigate the possible effect of Dex, which is easy to obtain and has low side effect potential, on LPS-induced brain damage and especially on the CREB/BDNF signaling mechanism associated with learning and memory.
Best practices, new perspectives and the perfect emollient: optimizing the management of contact dermatitis
Published in Journal of Dermatological Treatment, 2018
Jean-Marie Lachapelle, Ana Gimenez-Arnau, Martin Metz, Jill Peters, Ehrhardt Proksch
When considering CD, an ideal emollient must first and foremost be safe and effective. In light of this, ingredients such as dexpanthenol are particularly valuable: dexpanthenol is found in a number of cosmetic products, owing to its hygroscopic properties, which are thought to be attributable to the compound’s moisturizing effects. Moreover, dexpanthenol has also demonstrated hydrating and barrier-repairing effects on atopic skin, providing a clinically observable anti-irritative effect (84–86). An investigation into the effect of dexpanthenol on the skin barrier revealed that the excipient increases the molecular mobility of several lipid and protein segments of the stratum corneum to generate the properties of a hydrated skin in dehydrated conditions, thus improving skin barrier function (87). The effect of dexpanthenol on filaggrin expression is a topic that warrants further research.
Dry skin management: practical approach in light of latest research on skin structure and function
Published in Journal of Dermatological Treatment, 2020
Ehrhardt Proksch, Enzo Berardesca, Laurent Misery, Johan Engblom, Joke Bouwstra
The specialist panel also confirmed the important role of dexpanthenol in topical emollients for dry skin management. Among its multiple functions, dexpanthenol compensates for reduced hydration by increasing water content and by favorably influencing the molecular mobility/fluidity of the SC lipid lamellae and proteins. Another key feature of dexpanthenol is its beneficial effect on epidermal regeneration due to an enhancement of epidermal differentiation. By supporting the epidermal regeneration process, dexpanthenol contributes to barrier function recovery in dry skin conditions and helps to reestablish normal epidermal differentiation. The latter feature is important to address the long-term issues associated with dry skin and to interrupt the dry skin cycle.