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Micronutrients
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
As vitamin B5 is ubiquitous in all animal and plant tissues, its food sources are large. Some of the richest sources of pantothenic acid include liver, egg yolks, beef, poultry, milk, seafood, royal jelly of honey, brewer’s yeast, rice bran, molasses, wheat germ, cereals, cauliflower, kale, broccoli, tomatoes, avocado, lentils, split peas, peanuts, soybeans, potatoes, and sweet potatoes (3, 43).
Experimental Stomatology
Published in Samuel Dreizen, Barnet M. Levy, Handbook of Experimental Stomatology, 2020
Samuel Dreizen, Barnet M. Levy
Nelson et al.105 described the teratogenic effects of pantothenic acid deficiency in rats. Female Long-Evans rats, 60 to 65 days of age, were placed on a pantothenic acid-deficient diet from the day of breeding. Others were mated after approximately 4 to 20 days on the deficient diet and continued thereon. Control animals received the test diet for 18 to 20 days before breeding, then supplemented with pantothenic acid throughout gestation. Each group contained 20 to 24 rats.
The vitamins
Published in Geoffrey P. Webb, Nutrition, 2019
Pantothenic acid is a precursor of coenzyme A which is essential for many metabolic processes – note the acetyl CoA in carbohydrate and fatty acid metabolism and the succinyl CoA of the Krebs cycle. The vitamin is widely distributed in food and clinical deficiency is rare. A “burning feet” syndrome has been reported in severely malnourished prisoners of war and in experimental deficiency. Requirements for pantothenic acid are difficult to estimate accurately.
Antiperspirant effects and mechanism investigation of Mulisan decoction in rats based on plasma metabolomics
Published in Pharmaceutical Biology, 2022
Shan-Peng Ma, Wei-Ping Ma, Shi-Ning Yin, Xiang-Yue Chen, Xiao-Qing Ma, Bao-Hong Wei, Jing-Guang Lu, Hong-Bing Liu
Pantothenic acid, also known as vitamin B5, is a precursor of CoA. Recently, the relationship between pantothenic acid and immunity has attracted broad attention. Pantothenic acid can promote immune cells to produce cytokines (He et al. 2018). It plays a significant role in inflammation and regulates the innate immune response by adjusting CoA levels (Jung et al. 2017). CoA mainly plays the function of acyl carrier in metabolism, participates in the decomposition of sugar, fat and protein, promotes energy metabolism, and scavenges oxygen free radicals (Depeint et al. 2006; Naquet et al. 2020). CoA also participates in important biochemical reactions in the body, such as the tricarboxylic acid cycle, fatty acid synthesis and oxidation, amino acid metabolism, etc. (Shedid et al. 2018). Therefore, the metabolic pathway of pantothenate and CoA biosynthesis plays a vital role in body physiological health. In this study, MLS can significantly reverse the level of pantothenic acid to normal expression, indicating that MLS had good regulation on pantothenate and CoA biosynthesis. After the improvement of pantothenate and CoA biosynthesis, RP rats' energy metabolism and immune function could be improved to improve pathological sweating.
Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy
Published in OncoImmunology, 2022
Melanie Bourgin, Oliver Kepp, Guido Kroemer
Vitamin B5 (pantothenic acid) has recently joined the club of immunostimulatory B vitamins. Vitamin B5 is a precursor of coenzyme A (CoA), an essential cofactor for energy metabolism and fatty acid oxidation.20 CoA can be conjugated to acetate to form acetyl-CoA thioester, which plays a central role in the intersection between amino acid catabolism, glycolysis, fatty acid metabolism, as well as a donor of acetyl groups for acetylation reactions,21 and longer acyl-CoA derivatives, which serve as “activated” fatty acids to participate in intracellular fatty acid transport and lipid biosynthesis.22,23 Of note, a protective effect has been ascribed to vitamin B5 in the context of infection by Plasmodium falciparum, the pathogen responsible for malaria.24 Similarly, vitamin B5 supplementation of mice can afford protection against Mycobacterium tuberculosis, the infectious agent causing tuberculosis, through improved T cell-mediated immunity.25
The therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat model
Published in British Journal of Neurosurgery, 2020
Mehmet Fatih Korkmaz, Hakan Parlakpinar, Mehmet Nuri Erdem, Mehmet Fethi Ceylan, Levent Ediz, Emine Samdanci, Ersoy Kekilli
Peripheral nerve injury may result in functional or anatomical defects. However, a return to function may be seen following spontaneous regeneration in the distal nerve area.12 Pharmacological treatment is often preferred to surgical treatment. Experimental studies have reported the success of several pharmacological agents for the treatment of nerve injuries.13–18 DEX is a biologically active alcohol-analog of PA that is converted into PA inside the cell.6 Pantothenic acid exerts its anti-oxidative effects by increasing the synthesis of reduced GSH and associated peroxidase enzymes, which serve as the most important protective systems against lipid peroxidation and oxidative stress.19 Additionally, PA is incorporated into the structure of coenzyme A, induces epithelization, and exerts anti-inflammatory effects.20 As with many rat experiments, the experimental treatment we started before the injury, this is often done because pre-injury treatment seems to be much more effective than post-injury treatments, but it has obvious limitations with clinical practices as it’s not really an option.