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Scutellaria Species and Cancer Research
Published in Namrita Lall, Medicinal Plants for Cosmetics, Health and Diseases, 2022
Samantha H. Sherman, Lani Irvin, Prahlad Parajuli, Nirmal Joshee
Baicalin, a flavonoid isolated from the S. lateriflora, has been shown to suppress migration and invasion of an aggressive breast cancer cell line, MDA-MB-231, without any effect on cancer cell viability. Baicalin inhibits expression of markers for epithelial to mesenchymal transition (EMT), a phenomenon associated with metastatic events. In addition, in vivo study in xenograft mouse model illustrated that baicalin inhibits breast cancer metastasis to the lungs and liver (Zhou et al., 2017).
Biobased Products for Viral Diseases
Published in Mahendra Rai, Chistiane M. Feitosa, Eco-Friendly Biobased Products Used in Microbial Diseases, 2022
Gleice Ribeiro Orasmo, Giovanna Morghanna Barbosa do Nascimento, Maria Gabrielly de Alcântara Oliveira, Jéssica Missilany da Costa
Baicalin is a flavonoid purified from the medicinal plant Scutellaria baicalensis Georgi and has been shown to have anti-inflammatory and anti-HIV-1 activities (Li et al. 2000). The flavonoid baicalin inhibits HIV-1 infection on entry of the virus. The authors proposed that the flavonoid baicalin can be used as a basis for the development of new anti-HIV-1 agents.
Drug Nanocrystals
Published in Carla Vitorino, Andreia Jorge, Alberto Pais, Nanoparticles for Brain Drug Delivery, 2021
M. Ermelinda S. Eusébio, Ricardo A. E. Castro, Joäo Canotilho
As an example, Liu et al. [175] prepared nanocrystals of baicalin (Fig. 7.5e), a substance with potential for stroke and Alzheimer treatment [176], by high-pressure homogenisation using several stabilisers (polysorbate 80, TW80, poloxamer P188, poloxamer P407, RH40 and D-α-tocopherol polyethylene glycol succinate, TPGS). Particles were obtained with 50% drug load and sizes approximately 250 nm. Among the different nanosuspensions, in vitro absorption of proteins from human plasma was dependent on the nature of the stabiliser: for baicalin nanocrystals coated with TW80, TPGS, or a mixture of both stabilisers, relatively low amounts of opsonins were adsorbed, whereas high amounts of apolipoproteins were found. Pharmacokinetic studies comparing the performance of baicalin solution with TW80 and TW80+TPGS nanosuspensions were conducted in rats. Better results were obtained for TW80+TPGS-coated particles, with a four-fold increase in brain-targeting efficiency relative to the baicalin solution.
Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis
Published in Pharmaceutical Biology, 2023
Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang, Ling Shen
Baicalin is a flavonoid glycoside isolated from the dried roots of Scutellaria baicalensis Georgi, which is a dicotyledonous Labiaceae plant (Liao et al. 2021). It is reported that baicalin can be used to treat a variety of diseases (Wang et al. 2019; Yu et al. 2019; Wei et al. 2022). For example, Fan et al. (2022) found that baicalin could restore ovarian function in aged mice and improve hydrogen peroxide-induced granulosa cell injury. Chen et al. (2013) showed that baicalin could suppress the growth of ovarian cancer cells. In addition, baicalin was able to ameliorate the progression of PCOS by upregulating AMP-activated protein kinase (AMPK) protein (Wang et al. 2019). Meanwhile, Yu et al. (2019) reported that baicalin effectively reversed the phenomenon of elevated androgen level in the serum of PCOS rats. However, the role of baicalin in PCOS progression remains unclear. Thus, we investigated whether baicalin could affect the progression of PCOS by mediating miRNAs.
Baicalin suppresses interleukin-1β-induced apoptosis, inflammatory response, oxidative stress, and extracellular matrix degradation in human nucleus pulposus cells
Published in Immunopharmacology and Immunotoxicology, 2023
Xiaoliang Bai, Mingyan Yao, Xiaojuan Zhu, Yong Lian, Mingyuan Zhang
Baicalin is one of the flavonoids isolated from Scutellaria radix, which is a traditional Chinese medicine (TCM) with a long history of application in the treatment of heat-clearing and detoxicating [9]. Baicalin shows better absorption and higher bioavailability with oral bioavailability (OB) of 40.12% and drug-likeness (DL) of 0.75 (Figure 1(A)). It has been reported that baicalin exhibits significant pharmacological properties, such as anti-inflammatory, anti-microbial, anti-tumor, and anti-oxidant activities [10]. Importantly, as a flavonoid, baicalin exhibited excellent anti-inflammatory activity. Baicalin relieves lipopolysaccharide (LPS)-induced cell apoptosis and inflammatory reaction in liver cells through p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) pathways [11]. Baicalin ameliorates depressive-like behavior in a chronic unpredictable mild stress (CUMS) mice model [12]. Baicalin inhibits imiquimod-induced skin inflammation in a psoriasis murine model via inhibiting the interleukin (IL)-17/IL-23 axis [13]. Baicalin exerts anti-inflammatory and cell-protective effects on Salmonella Typhimurium-induced inflammatory injury in RAW264.7 cells and H9 cells [14].
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway
Published in Pharmaceutical Biology, 2022
Hui Wang, Qingtao Jiang, Lizhu Zhang
Baicalin is a flavonoid extracted from the dried root of Scutellaria baicalensis with many pharmacological effects. Animal experiments and clinical studies have confirmed that baicalin has antifibrosis and organ protection effects (Xiao et al. 2018). However, the precise role and potential mechanisms have yet to be revealed. In the current study, UUO mouse models were established and treated with varying doses of baicalin. Baicalin treatment clearly ameliorated RIF in UUO mice, confirming the protective effects of baicalin on RIF. Fibroblasts are intrinsic cells in the renal interstitium that transform into myofibroblasts under the stimulation of TGF-β (Sun et al. 2016). Recent studies have confirmed that myofibroblasts are associated with RIF and are the key effector cells. The phenotypic transformation of fibroblasts and renal cells to myofibroblasts is an important mechanism leading to RIF. Interestingly, baicalin provided significant protection against TGF-β1-induced myofibroblasts.