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Ethnopharmacological Properties of Some Threatened Medicinal Plants
Published in Jayanta Kumar Patra, Gitishree Das, Sanjeet Kumar, Hrudayanath Thatoi, Ethnopharmacology and Biodiversity of Medicinal Plants, 2019
Sanjeet Kumar, Padma Mahanti, Gitishree Das, Jayanta Kumar Patra
The plant parts such as roots, leaves, stem, flowers, tubers, fruits, bark, gum or resinous extract are used against different diseases and disorders. When the seeds of Celastrus paniculatus were macerated, and oil was obtained. The oil is used to enhance the memory of abnormal children (Kulkarni et al., 2011). The juice of resin of Gardenia gummifera was used to kill the intestinal worm (Nayak et al., 2011). It was also observed that tuber paste of Gloriosa superba was applied externally to reduce the joint pain among the old age people of tribal communities of Kendujhar (Akhtar, Haqqi, 2012). The tuber juice of this plant is taken for abortion. The bark decoction of Oroxylum indicum is used to treat throat infections (Payne et al., 2013). It was noted that fruits juice of Piper longum is used to cure cough and asthma (Okwu, Nnamdi, 2011). The leaf juice of Pterocarpus marsupium was taken to control diabetes (Liu et al., 2005) and tuber paste of Pueraria tuberosa was used as an emollient paste (Aburjai, Natsheh, 2003). The root paste of Rauvolfia serpentine is used against snake bites (Gomes et al., 2010) and leaves and fruits paste of Scindapsus officinalis is applied to reduce inflammation (Nijveldt et al., 2001).
Increasing the Sensitivity of Adipocytes and Skeletal Muscle Cells to Insulin
Published in Christophe Wiart, Medicinal Plants in Asia for Metabolic Syndrome, 2017
Oroxylin A from Oroxylum indicum (L.) Kurz. at a concentration of 20 μM abrogated the differentiation of 3T3 preadipocytes (induced by dexamethasone-insulin-3-isobutyl-1-methylxanthine) as evidenced by a decreased triglyceride accumulation by 61.2% and adiponectin secretion by 31.4%.283This flavone (Figure 4.21) decreased the expression of peroxisome proliferator-activated receptor-γ and downstream fatty acid synthetase and lipoprotein lipase.283 In mature 3T3-L1 adipocytes, this flavone induced lipolysis as evidenced by increased expression of glycerol, it increased tumor necrosis factor-α secretion and decreased Akt phosphorylation.283
Trade in Indian Medicinal Plants
Published in T. Pullaiah, K. V. Krishnamurthy, Bir Bahadur, Ethnobotany of India, 2017
D. K. Ved, S. Noorunnisa Begum, K. Ravi Kumar
As far as the 70 species mainly sourced from the tropical forests (Table 7.2) are concerned, it is alarming to note that most of these are trees or woody perennials with many of them occurring in specialized niches. Of special concern are the tree species like Oroxylum indicum (L.) Benth.ex Kurz, Stereospermum chelonoides (L.f.) DC., & Premna serratifolia L. [= P. integrifolia L.] the roots of which form part of the popular Ayurvedic raw drug group ‘Dashamoola’. With no current management focus for promoting populations of such species, their populations are on the decline and would need to be urgently built up if herbal industry is to be fed with regular supplies of these species, as the current level of estimated consumption exceeds 1000 MT in respect of each of these species. All the 70 species needs focused and urgent attention by NMPB.
Application of the Mannich reaction in the structural modification of natural products
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Miao-Xia Pu, Hong-Yan Guo, Zhe-Shan Quan, Xiaoting Li, Qing-Kun Shen
Oroxylin A, a flavonoid from the Indian herb Oroxylum indicum, is a potent inhibitor. Babu et al.87 designed and synthesised a series of 8-aminomethylated derivatives based on oroxylin A with a methoxy group at the 6th position through the Mannich reaction and evaluated their effects on rat intestinal and yeast α-glucosidase inhibitory activities. The synthesised compounds significantly enhanced the a-glucosidase-inhibitory activity of the lead compounds (Table 4). Among them, compound 67 (Figure 5) with N-methyl piperazine at the C8 position showed the strongest inhibitory activity, with IC50 values of 35.43 and 98.84 µg/mL for rat intestinal a-glucosidase and yeast a-glucosidase, respectively. Regarding the structural features of the active Mannich bases, the results indicate that the 5,7-dihydroxy-6-methoxy groups on the A-ring of the flavonoid are the basis of glucosidase inhibition activity. Alicyclic amine substituents significantly improved the intestinal a-glucosidase inhibitory potential of the parent compound. Among them, the N-methylpiperazinyl substitution had the strongest inhibitory effect. This experiment showed that the introduction of alicyclic amines into natural compounds can significantly improve their activity, providing a direction for the results of natural products.
Development and evaluation of Chrysin-Phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity
Published in Journal of Microencapsulation, 2018
Shahadali Komath, Anuj Garg, Muhammad Wahajuddin
Chrysin (5, 7-dihydroxyflavone) is an extensively distributed flavonoid which can be obtained from Propolis, honey, and extracts of numerous plants species. It is a primary active chemical constituent of the Indian trumpet trees (Oroxylum indicum) (Jung 2016). Chrysin showed a wide spectrum of biological and pharmacological activities like anti-oxidant, anti-inflammatory, anti-diabetic, anti-cancer, anti-haemolytic, anti-hypertension, and neuroprotection (Kasala et al.2016, Jung 2016). Chrysin was reported to inhibit the growth of tumour cell by destruction of intracellular GSH concentrations due to antioxidant property, inhibition of angiogenesis and induction of apoptosis in different cell lines (Kasala et al.2016). A higher daily dose was required to prevent the growth of MDA-MB-231 cells and 4T1 cells in animal models, because of its poor bioavailability (Sun et al. 2012, Lirdprapamongkol et al. 2013).
Synergistic Antiproliferative Effects of Co-nanoencapsulated Curcumin and Chrysin on MDA-MB-231 Breast Cancer Cells Through Upregulating miR-132 and miR-502c
Published in Nutrition and Cancer, 2019
Naser Javan, Mohammad Hassan Khadem Ansari, Mehdi Dadashpour, Mehran Khojastehfard, Milad Bastami, Mohammad Rahmati-Yamchi, Nosratollah Zarghami
Chrysin (Chr), a natural flavone, widely found in several plant extracts including passion flowers, Oroxylum indicum, honey, and propolis (15). Cancer chemoprevention effect is the most promising among the numerous pharmacological activities presented by Chr (16). Pre-clinical studies have revealed that Chr exhibits its antitumor activities via selective modulation of various cell signaling mechanisms that are connected to survival, proliferation, inflammation, angiogenesis, invasion and metastasis of cancer cells (17,18). This wide range of anticancer effects in conjunction with low toxicity and adverse side-effects to normal cells highlights a translational route for cancer treatment (19).