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Enteral and Parenteral Devices
Published in Praveen S. Goday, Cassandra L. S. Walia, Pediatric Nutrition for Dietitians, 2022
Ruba A. Abdelhadi, Ammar R. Barakat, Beth Lyman
Granulation tissue is excess tissue that appears around the stoma site. Some children are more prone to granulation tissue. This complication is more likely to occur with increased movement and pulling on the tube. It is further exacerbated by excess moisture around the site. If not treated, granulation tissue may become infected or may continue to increase in size, causing bleeding and discomfort. If the granulation tissue develops an epithelialized layer above it, this will leave a raised ridge above the skin. For these reasons, it is important to manage and eliminate the development of granulation tissue. To minimize the chances of developing granulation tissue, the extension tubing should be disconnected from the EAD when not in use, and the peristomal skin should be kept clean and dry with a moisture wicking dressing. Depending on the severity, granulation tissue may be treated by a provider or nurse with moisture wicking dressing, topical medication, or silver nitrate. Work with the NST to determine the best course of treatment for granulation tissue.
Dysarthria associated with hypoglossal nerve palsy and COVID-19
Published in Margaret Walshe, Nick Miller, Clinical Cases in Dysarthria, 2021
Voice assessment: Laryngeal examination involved an instrumental fiber-optic endoscopic evaluation. Whilst this assessment was conducted for the purposes of examining swallowing safety at the pharyngeal and laryngeal levels, it also provided valuable information on laryngeal motility, which was described as normal. There was no impairment with adduction and abduction of the vocal folds (Supplementary Material Video 3.2). Oedema in the arytenoid mucosa was noted with laryngeal granulation above and beneath the vocal folds. Tissue granulation develops in response to irritation or injury. In this case, it was hypothesised that it was caused by the oral-tracheal intubation in ICU.
Granulation Characterization
Published in Dilip M. Parikh, Handbook of Pharmaceutical Granulation Technology, 2021
Granulation can be characterized on the basis of at least four levels [6].Molecular: Distribution and structureSurface: Both as transitional surfaces and particle surfaceGranular: The primary particle, transition, porosity, size, and shapeGranulation or bulk characteristics
Outcomes of frontolateral vertical partial laryngectomy in T1b glottic carcinomas
Published in Acta Oto-Laryngologica, 2021
Rawad Jadeed, Martin Westhofen
The postoperative follow-up period was 54 to 120 months (mean 79.95 ± 20.59 months, n = 39). One month postoperative 34 of 39 of the patients (87.2%) had no complications, while 5 (12.8%) had wound healing problems and 4 (10.3%) developed fistula after closing the tracheotomy fistula. Patients with fistula formation had successful intravenous antibiotic treatment and topical antibiotic wound dressing for a week. Within 2 years after FVPL, granulation tissue formation und synechia were seen in 13 of 39 patients (33.3%). A localized granulation tissue in the area of the former AC was found in 9 patients. In 4 patients, the granulation tissues were more extensive with connections between the two vocal folds in the anterior third in the form of a synechia. These diagnoses were made during regular tumor follow-ups in the first 3 months after the operation. As soon as this diagnosis was established, microlaryngoscopy was used to exclude tumor recurrence and to remove the tissue changes using a CO2 laser a socalled neoglottic plastic i.e. extension. In patients with synechia, this included synechia cutting. The procedure was sufficient the first time in 6 patients. Unfortunately, 7 patients had neoformation of the granulation tissue and it was necessary to repeat the procedure 3 times within 2 years in 3 patients and 4 times in 4 patients.
Hunner lesion disease differs in diagnosis, treatment and outcome from bladder pain syndrome: an ESSIC working group report
Published in Scandinavian Journal of Urology, 2020
Magnus Fall, Jørgen Nordling, Mauro Cervigni, Paulo Dinis Oliveira, Jennifer Fariello, Philip Hanno, Christina Kåbjörn-Gustafsson, Yr Logadottir, Jane Meijlink, Nagendra Mishra, Robert Moldwin, Loredana Nasta, Jorgen Quaghebeur, Vicki Ratner, Jukka Sairanen, Rajesh Taneja, Hikaru Tomoe, Tomohiro Ueda, Gjertrud Wennevik, Kristene Whitmore, Jean Jacques Wyndaele, Andrew Zaitcev
Biopsy retrieval and histopathology evaluation are important in the diagnosis of BPS to exclude confusable diseases. In non-HLD phenotypes, the majority of histopathology features are slight and non-specific, while certain signs are characteristic for HLD. Deep biopsies including bladder muscle have been recommended, since the disease process involves superficial as well as deeper layers of the bladder wall. Specimens from patients with HLD display striking histologic alterations with prominent ulcerations that may be covered by fibrin mixed with inflammatory cells, in particular neutrophils. The lesions are often wedge-shaped and involve the superficial part of the lamina propria, often extending into the muscularis mucosae. Underlying granulation tissue is present in the vast majority of the subjects. There is often denudation of the urothelium, but if present reactive changes are common (Figure 2(A)).
Cryptotanshinone enhances wound healing in type 2 diabetes with modulatory effects on inflammation, angiogenesis and extracellular matrix remodelling
Published in Pharmaceutical Biology, 2020
Min Song, Lu Chen, Lusha Zhang, Chunxiao Li, Joel Wake Coffie, Zhirui Fang, Liyuan Zhang, Shaoxia Wang, Xiumei Gao, Hong Wang
Based on the anatomical structure of skin, granulation is a new connective tissue which occurs from the base of the wound and contains microscopic blood vessels. The epithelial gap represents distance between the leading edge of migrating keratinocytes. It is the process of covering open wounds with new epithelial surfaces to create a barrier between the wound and the external environment. They are measured in H&E-stained sections of wounds displayed in Figure 2(A). In the CT-treated wounds, GT is thicker and re-epithelialization was faster compared with CMC-Na-treated wounds at day 16 post-wounding. Quantitative calculations of the GT thickness and re-epithelialization of the wounds confirmed that CT treatment significantly enhanced GT thickness and decreased epithelial gap (Figure 2(B,C); p < 0.05, p < 0.01, respectively). Therefore, in addition to wound contraction, CT treatment significantly promoted GT formation and re-epithelialization in open wounds.