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Comparative Pathology — Human Large Intestinal Cancer And Animal Models
Published in Herman Autrup, Gary M. Williams, Experimental Colon Carcinogenesis, 2019
Also called villous adenoma, villous polyps are less common than the adenomatous polyps and have distinctly different morphological as well as biological features. These are most often sessile lesions with broad base. Unlike the adenomatous polyps, the entire polyp is neoplastic. The polyp appears as if it has been plastered on to the mucosa. The surface of the polyp is characterized by finger-shaped structures reminiscent of the villi in the small intestine and, hence, the name villous polyps. Generally the morphological features of malignancy are more predominant throughout the entire polyp than that seen in adenomatous polyps. Villous polyps are also generally larger than the adenomatous polyps and the potential to progress to carcinomas is likewise much higher than any other polyps described earlier.5
Endoscopy and Management of Colorectal Polyps
Published in Peter Sagar, Andrew G. Hill, Charles H. Knowles, Stefan Post, Willem A. Bemelman, Patricia L. Roberts, Susan Galandiuk, John R.T. Monson, Michael R.B. Keighley, Norman S. Williams, Keighley & Williams’ Surgery of the Anus, Rectum and Colon, 2019
As a result of the low complication rate and the high efficiency of endoscopic polypectomy and mucosal resection, this is the treatment of choice for colorectal adenomas. All endoscopic techniques should be fully utilised to ensure a complete resection of the adenoma, especially in villous adenoma. It is essential to obtain an accurate histopathological assessment in the prevention of local recurrence.
Presacral resections - Kraske
Published in P Ronan O’Connell, Robert D Madoff, Stanley M Goldberg, Michael J Solomon, Norman S Williams, Operative Surgery of the Colon, Rectum and Anus Operative Surgery of the Colon, Rectum and Anus, 2015
Because of technical advances with transanal resection techniques (see Chapter 6.14) and TEMS (see Chapter 6.15), it is now rarely necessary to perform a segmental resection of the lower rectum. However, the approach may be useful on occasions, particularly for circumferential villous adenoma of the lower third of rectum.
Serum macrophage inhibitory cytokine-1 serves as a novel diagnostic biomarker of early-stage colorectal cancer
Published in Biomarkers, 2021
Chunyang Dai, Xiaolei Zhang, Yanling Ma, Zhaowu Chen, Shaohua Chen, Yang Zhang, Ming Li
This study was based on the Colorectal Cancer Early Diagnosis and Treatment Project conducted in Hefei City, Anhui Province. We selected information from the Urban Society’s questionnaire given to asymptomatic normal persons from January 2014 to May 2016. The selection criteria were as follows: (1) age, 40–75 years, permanent resident of Hefei City; (2) cognitively proficient; (3) no serious heart, brain, lung, or kidney function conditions or mental illness; (4) compliance with the study protocol, voluntary participation, and signed informed consent agreement. Subjects’ characteristics analyzed included age, sex, body mass index (BMI), smoking status, and family history of tumours. Among 2759 patients who underwent colorectal endoscopy, 19 were diagnosed with invasive CRC, and 47 were diagnosed with the precancerous lesions as follows: (a) high-grade glandular intraepithelial neoplasia; (b) villous adenoma; (c) tubular adenoma; (d) multiple polyps (n > 10); or adenomatous polyps (≥1 cm diameter).
Villous adenoma of the urethra
Published in Baylor University Medical Center Proceedings, 2021
Katherine E. Dowd, Derek Yang, Harry Papaconstantinou, Erin T. Bird
Villous adenoma is commonly encountered in the colorectal practice but is rarely seen by the urologic surgeon. Fibroepithelial urethral polyps are more readily seen by the urologist; they are generally benign and can be treated with local resection/ablation to resolve irritative voiding symptoms. Other encountered benign urethral lesions include hemangiomas, leiomyomas, urethral diverticulum, and cowpers gland or skenes gland duct cysts. Due to the variability of presentation of suspicious lesions, most urologists opt for biopsy at the time of resection or fulguration to rule out underlying malignancy. Villous adenomas of the genitourinary tract have been reported, but generally in small case series or reviews of case reports.1 They present similarly to other urethral lesions—with gross hematuria, dysuria, or irritative voiding symptoms—and a histopathologic diagnosis is usually needed.1 Because reports of association with adenocarcinoma exist, most authors recommend full resection of the lesion and consideration of magnetic resonance imaging (MRI) and colonoscopy to rule out coexisting adenocarcinoma or malignancy.2 The tumor is more commonly encountered at the bladder dome, trigone, and urachus if present.3
Mucinous cystadenocarcinoma in the renal pelvis: primary or secondary? Case report and literature review
Published in Acta Chirurgica Belgica, 2020
An Tamsin, Charlotte Schillebeeckx, Charlotte Van Langenhove, Kathy Vander Eeckt, Dieter Ost, Kevin Wetzels
Diagnosis is usually made only after tumor excision. Pathological examination often shows a mucinous cyst. Isolated mucus within the kidney is uncommon and reported causes of muconephrosis include mainly metastasis of appendiceal mucinous cystadenocarcinoma, mucus-secreting adenocarcinoma of the renal pelvis, villous adenoma originating from urothelial metaplasia, and renal papillary adenoma [10]. Our architectural/morphological findings are not compatible with villous adenoma or renal papillary adenoma and the overwhelming cystic aspect doesn’t fit with the diagnosis of pure adenocarcinoma. Mucinous cystadenocarcinoma of the renal pelvis has a tendency to involve the broad pelvicalyceal area, as in our case [8]. Pathologic appearance defines the malignant character of a mucinous cystadeno(carcino)ma, according to stromal invasion, nuclear atypia, and multilayers of neoplastic cells. Especially stromal invasion is the definitive marker of malignancy [6].