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Cardiac Tumours
Published in Mary N. Sheppard, Practical Cardiovascular Pathology, 2022
Undifferentiated sarcomas are particularly aggressive and high-grade. Eighty per cent of patients with spindle-cell sarcoma have metastases at the time of diagnosis. Spindle-cell sarcoma lacks a specific and universal histological grading scheme. The prognosis of cardiac primary spindle-cell sarcomas is poor with a mean survival of 3 months to 1 year.
Hereditary Multiple Osteochondromas
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Resulting from malignant transformation in the cartilage cap of osteochondroma, secondary peripheral chondrosarcoma confers 10-year survival rates of 83% and 29% for grade I and III chondrosarcomas, respectively. Further, osteosarcoma and spindle cell sarcoma may develop in the stalk of the osteochondroma occasionally.
The Vascular Morphology of Tumors
Published in Hans-Inge Peterson, Tumor Blood Circulation: Angiogenesis, Vascular Morphology and Blood Flow of Experimental and Human Tumors, 2020
Lewis24 described the vascular patterns of a fibrosarcoma, a spindle-cell sarcoma, and a round-cell sarcoma of rats. The fibrosarcoma possessed a pattern that was similar to that of normal s.c. tissue. There was a rich capillary net and large afferent and efferent vessels. In contrast, the spindle-cell sarcoma formed a viable shell around a necrotic center. Within the peripheral shell was a rich plexus of fine capillaries, particularly abundant close to the necrotic center. The capillaries beneath the capsule contained elongated loops. The round-cell sarcoma possessed yet a further vascular pattern. In this type, there developed large necrotic centers and a thin shell of peripheral living tumor 1 to 2 mm in thickness. The vigorous part of the tumor was limited centrally by the zone of blood vessels. The zone of capillaries and the necrotic center were separated by two zones in which there were different stages of degeneration. The vessels of this type of sarcoma were coarser than that of the spindle-cell sarcoma. The capillary plexus was abundantly supplied with large afferent and efferent vessels. There were only short distances between such vessels and the terminal capillary plexus next to the degenerating tissue. All of these tumors arose spontaneously in rats of strain P in Dr. George Walker’s rat colony, and the specific organs of origin were the fibrosarcoma from tissues of the breast , the spindle-cell sarcoma from the liver, and the round-cell sarcoma from the wall of the vagina.
Bone sarcoma during pregnancy: an example of personalized multidisciplinary care
Published in Acta Oncologica, 2019
Marije Weidema, Suzanne Kaal, Loek de Jong, Nielka van Erp, Rosemarie Jansen, Bart Schreuder, Wieteke Heidema, Winette van der Graaf, Ingrid Desar
During chemotherapy, fetal well-being was monitored by the gynecologist. Two courses of chemotherapy resulted in a metabolic but not volumetric response of the tumor (Figure 1). At the pregnancy term of 29 + 5 weeks, we proceeded to limb saving surgery with a mega-prosthesis reconstruction. Fetal monitoring during and after surgery did not show any negative effects for the baby. The diagnosis of a high-grade pleomorphic undifferentiated spindle cell sarcoma was confirmed by the pathologist, with resection margins of at least 2 cm and a therapy effect of 50–60% necrosis, the latter below the preferred percentage of >90%. Because of the necessity of highly teratogenic adjuvant chemotherapy after surgery, prematurely cesarean section was scheduled at 32 + 0 weeks of gestation and a healthy daughter was delivered (weight 1870 g, p50–80, Apgar score 8/9 after 1/5 min). Due to prematurity, but not dysmaturity, the baby was admitted to the Neonatal Care Unit for almost 7 weeks. No adverse effects, especially no hearing impairment, were discovered until the age of 2 years, whereafter she was discharged from further pediatric follow-up.
Locally advanced carcinosarcoma of the pancreas
Published in Baylor University Medical Center Proceedings, 2018
Sasha A. Still, Carlos R. Becerra, Stacia E. Clement-Kruzel, Keith M. Cavaness
The IHC diagnosis of carcinosarcoma is established by visualizing positive reactivity of the carcinomatous elements to cytokeratin and of sarcomatous elements to vimentin or desmin. Additional IHC investigation typically is done to verifiably rule out other types of tumors. In the current study, the tumor tested positive for desmin and cytokeratin. Histologically, the tumor demonstrated moderately differentiated adenocarcinoma and high-grade spindle cell sarcoma. The majority of carcinosarcoma cases in the literature are composed of similar cellular components.3,4
Pleuropulmonary blastoma: Difficulty in diagnosis and treatment of a case in Vietnam
Published in Pediatric Hematology and Oncology, 2021
Bui Ngoc Lan, Le Thi Kim Ngoc, Hoang Ngoc Thach, Phan Canh Duy
The result of pathology in previous month revealed suspected PPB and needed more immunohistochemistry. The core needle biopsy under the ultrasonography was performed at this time. Microscopy showed the solid and cystic areas that contained blastema and spindle cell sarcoma features (Figure 4). Immunohistochemistry staining, the tumor cells were positive for Myogenin (10%), Desmin (focal), Vimentin, Ki67 (10%), SMA (focal) and negative for LCA, EMA. The tumor was diagnosed pleuropulmonary blastoma, type II and had been reviewed by experienced pathologists in Vietnam.