China
Africa
Explore chapters and articles related to this topic
Acquired Laryngotracheal Stenosis
Published in R James A England, Eamon Shamil, Rajeev Mathew, Manohar Bance, Pavol Surda, Jemy Jose, Omar Hilmi, Adam J Donne, Scott-Brown's Essential Otorhinolaryngology, 2022
Other—KTP and Nd:YAG lasers can be delivered through a fibre, permitting management of tracheobronchial disease. Pulsed-dye laser in the paediatric population is being evaluated. Photodynamic therapy has significant side effects due to photosensitivity. Coblation® is not widely used for RRP.
Premalignant Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Ablative laser therapies are effective, but the risk of recurrence or malignancy ranges between 0–15%. Photodynamic therapy has been used with mixed results. There have been reports that mild epithelial dysplasia has spontaneously regressed without intervention, which makes observation a reasonable initial approach in certain cases; however, these reports may reflect trauma-induced reactive changes that are distinct from the characteristic dysplastic lesions that carry the risk of progression to carcinoma.
Malignant Tumors and the Microcirculation
Published in John H. Barker, Gary L. Anderson, Michael D. Menger, Clinically Applied Microcirculation Research, 2019
Bernhard Endrich, Peter Vaupel
It should also be mentioned that comparable microvascular damage has been reported upon photodynamic and shock-wave therapy.8,132,133 Based on encouraging experimental data, photodynamic therapy has also been used clinically.132
Octreotide and Octreotide-derived delivery systems
Published in Journal of Drug Targeting, 2023
Mingliang Fan, Yue Huang, Xinlin Zhu, Jiayu Zheng, Mingwei Du
Photodynamic therapy is a form of phototherapy which relies on the interaction of photosensitizer, light and oxygen. In order to improve tumour targeting ability of photosensitizer and prevent collateral damage to healthy tissue, Martin P. van Hagen’s group synthesised two conjugates containing photosensitizer Chlorin e6 (Ce6) and Y3-TATE: Ce6-K3-Y3-TATE and Ce6-Y3-TATE-K3-Y3-TATE, a tri-lysine linker (K3) was introduced to improve hydrophilicity. Compared with free Ce6, Ce6-K3-Y3-TATE had higher photostability but lower phototoxicity, exhibiting SSTR2-mediated uptake in subcutaneous SSTR2+ AR42J acinar pancreas tumour implants. Although another conjugate Ce6-Y3-TATE-K3-Y3-TATE contains two TATE peptide sections, it showed no specific effect due to increased hydrophobicity, the specific recognition between this conjugate and SSTR2 was outweighed by the non-specific accumulation with in cells [81].
aMMP-8 point-of-care - diagnostic methods and treatment modalities in periodontitis and peri-implantitis
Published in Expert Opinion on Therapeutic Targets, 2023
Hanna Lähteenmäki, Tommi Pätilä, C Pirjo Pärnänen, Ismo Räisänen, Taina Tervahartiala, Shipra Gupta, Timo Sorsa
Biofilm can be removed with careful anti-infective treatment, but bacteria that have already penetrated the tissue defense somehow survive. This issue has led to further research into the possibilities of different light treatments to eliminate those pathogens [86–88]. Dental clinicians so far have almost no chance of destroying these pathogens so an alternative method to treat drug-resistant bacterial infections is needed [89]. Photodynamic therapy (PDT) is a method that is based on local application of a photosensitive compound (the photosensitizer). This accumulates in pathological tissues. The photosensitizer molecules absorb the light of the wavelength, initiating the activation processes that lead to the destruction of the cells. The photodynamic therapy is well tolerated. The ease of application allows for home use [89]. Several studies have also demonstrated that bacterial destruction in dental implant tissues can be achieved without any damage to the treated titanium surfaces [90].
Steering light in fiber-optic medical devices: a patent review
Published in Expert Review of Medical Devices, 2022
Merle S. Losch, Famke Kardux, Jenny Dankelman, Benno H. W. Hendriks
The retrieved patents show that remote light delivery is an issue relevant to various applications involving tissue diagnostics and therapeutics. Spectroscopic devices use light to assess tissue type and status based on its optical properties [99]. Physicians apply spectroscopy to recognize diseases [100] and to distinguish tumors from healthy tissue [101]. On the other hand, photodynamic therapy is used to treat cancer by destroying malignant cells with a combination of light energy and a photosensitive drug [102]. Light can also provide treatment for various other medical conditions, such as benign prostatic hyperplasia [103], kidney and bladder stones [104], or incontinence [105]. New designs can support tissue diagnostics and therapeutics in hardly accessible locations of the body by providing light delivery to and collection from tissue off-axis.