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Adult Ocular and Orbital (Ocular Adnexa) Tumors
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
P.N. Plowman, Rachel Lewis, J.L. Hungerford
The orbit is one of the more common sites of extranodal origin of lymphoma, and orbital lymphoma is a disease that must be distinguished from the rare ocular lymphoma (see above). Almost all orbital lymphomas are of B-cell origin; Hodgkin disease rarely affects the orbit.
Lymphoma
Published in Anju Sahdev, Sarah J. Vinnicombe, Husband & Reznek's Imaging in Oncology, 2020
Sarah J Vinnicombe, Rodney J Hicks
Non-Hodgkin lymphoma is the most common primary orbital malignancy in adults, accounting for 10% of orbital masses (123) and about 2% of all primary extranodal NHL. Primary orbital lymphoma occurs most commonly in patients between the fifth and seventh decades and typically presents as a slow-growing infiltrative mass for which the main differential diagnosis is orbital pseudotumour. Secondary orbital involvement occurs in approximately 5% of NHL. Lymphomas can arise from the conjunctiva, eyelids, lacrimal glands, or retrobulbar tissues. Proptosis and ophthalmoplegia occur, with variable effects on visual acuity depending on the site of involvement. The usual subtypes are MALT and DLBCL. Up to 50% will prove to have disseminated disease on staging.
Orbital resection and reconstruction
Published in John Dudley Langdon, Mohan Francis Patel, Robert Andrew Ord, Peter Brennan, Operative Oral and Maxillofacial Surgery, 2017
Orbital lymphoma is the most common malignant tumour of the eyes. It can occur either as the primary site of disease or rarely as a secondary site of systemic non-Hodgkin lymphoma (NHL). Orbital lymphoma typically is a disease of the elderly as the majority are non- Hodgkin’s type and are seen primarily in adults in the 50–70-year age group.
Lymphoma and inflammatory disorders presenting in the orbit– a comparison of characteristics from a 10-year series in a tertiary hospital
Published in Orbit, 2022
Samantha Hunt, Ioana Pereni, Rebecca Ford, Helen Garrott
Pain is often considered as a key symptom in orbital inflammatory disease, occurring less frequently in orbital lymphoma.3,4 In our sample, pain was a symptom in 44% of patients with OID compared with 38% of those with lymphoma. The frequency of pain for patients with lymphoma was similar to the literature,4 but our cohort of patients with OID had much lower rates than have previously been reported.3 The difference in frequency of pain occurrence between the groups did not reach statistical significance on Chi-square testing, and therefore was not a presenting feature that could help clinically distinguish between OID and lymphoma. The only presenting feature in our cohort that did reach statistical significance and might be more supportive of a diagnosis of OID was lid swelling/puffiness, which occurred in 56% of patients.
Radiotherapy for Orbital Pseudotumor: The University of Florida Experience
Published in Cancer Investigation, 2018
Meriem Mokhtech, Sommer Nurkic, Christopher G. Morris, Nancy P. Mendenhall, William M. Mendenhall
There were 8 recorded adverse events in 7 patients. Acute side effects were negligible. All patients tolerated RT with no complications. Two patients developed grade 2 cataracts at 3 years and 3.25 years. One of these patients went on to develop grade 3 cataracts in the contralateral eye. Two patients developed grade 1 dry eye at 9 months and 1.4 years. The one patient who exhibited symptom progression during RT was diagnosed with orbital lymphoma 3 months after treatment and later developed blindness in the treated eye, likely associated to the progression of the lymphoma, but was recorded as a grade 4 event nonetheless. One patient developed Brown’s syndrome (superior oblique dysfunction) at 9 years after RT and 1 patient developed diplopia following surgery, but before RT; both were grade 1. None of the patients died due to OP or treatment-related complications.
Mucosa-associated lymphoid tissue lymphoma with intraocular and orbital involvement: case presentation and review of the literature
Published in Orbit, 2018
We report a case of simultaneous intraocular and orbital MALT lymphoma in an immune-competent patient. The patient presented with the mass-effect signs of orbital lymphoma and was also found to have uveal involvement upon presentation confirmed by computed tomography and fundus photography. The severe degree of orbital involvement seemed to suggest an orbital lymphoma with adjacent intraocular spread, which has not been previously reported. However, due to the simultaneous presentation, it is possible that the patient could have had primary uveal lymphoma that spread to the orbit. In the latter scenario, the degree of orbital involvement also makes the case unique.