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Soft Tissues
Published in Joseph Kovi, Hung Dinh Duong, Frozen Section In Surgical Pathology: An Atlas, 2019
DIFFERENTIAL DIAGNOSIS: ClinicalTo differentiate fibrosarcoma from fibromatosis see the discussion on differential diagnosis, clinical, under fibromatosis.*MicroscopicFor microscopic differential diagnosis of fibrosarcoma and fibromatosis, see discussion elsewhere.**
Neoplasms of the Nasal Cavity of Cattle and Sheep
Published in Gerd Reznik, Sherman F. Stinson, Nasal Tumors in Animals and Man, 2017
Usually the diagnosis of fibrosarcoma is made only on the basis of the histological criteria mentioned above. It is, however, important to remember that most of these tumors, although they appear to be malignant, are actually benign.
Fibrosarcoma
Published in Dongyou Liu, Tumors and Cancers, 2017
Fibrosarcoma of bone may cause pain or soreness (due to suppressed nerves and muscles), swelling, loss of motion (limp or difficulty using legs, feet, arms, and hands), and pathologic fracture (following trivial trauma). New pain and/or swelling at a sight of known fibrous dysplasia is indicative of malignant transformation. Adult fibrosarcoma of soft tissue is generally a large, painless mass deep to fascia with an ill-defined margin.
Nanodesigning of multifunctional quantum dots and nanoparticles for the treatment of fibrosarcoma
Published in Journal of Microencapsulation, 2022
Gulen Melike Demirbolat, Levent Altintas, Sukran Yilmaz, Taibe Arsoy, Mahmut Sözmen, Ismail Tuncer Degim
Fibrosarcoma, which stems from fibroblasts (fibrous connective tissue) predominantly found in the area around bones or the soft tissues, is one type of malignant tumour of mesenchymal cell origin. Fibrosarcoma tends to recur frequently and quickly metastasise. The primary treatment option for fibrosarcoma is surgical removal, but recurrence may occur years after the treatment. Therefore, the necessity of complementary therapy, such as chemotherapy and radiotherapy, has been increasing in popularity (Behzadi et al. 2017, Zielichowska et al. 2016). Chemotherapy is one of the frontline strategies employed in the treatment of many types of tumour (Zhu et al. 2017). The main aim of anticancer chemotherapy is the eradication of tumours and metastatic malignant cells at the first stage. The conventional anticancer drugs, administered through the parenteral route at the maximum tolerated dose, in practice cause suffering in patients (Beretta et al. 2017). The efficacy of the vast majority of cancer therapeutics is often limited for such reasons as non-specific biodistribution, insufficient accumulation in tumour tissue, or undesirable side effects (Guven et al. 2017). Hence, researchers have been continuously striving to develop a more efficient way to administer anticancer drugs, to selectively target tumour tissues and improve efficacy while minimising undesirable side effects and the aforementioned limitations (Gao et al. 2014, Birhanu et al. 2017).
Fetal Mediastinal Fibrosarcoma. Report of Two Cases
Published in Fetal and Pediatric Pathology, 2022
Murat Cagan, Selma Yildirim, Gulenay Gencosmanoglu Turkmen, Ozgur Ozyuncu, Zuhal Akcoren, Ozgur Deren, Safak Gucer
The frequency of detection has increased due to improvements in sonographic imaging and prenatal follow-up. Ultrasonography is usually used to detect fetal tumors, and fetal magnetic resonance imaging (MRI) can be a complementary tool. Prenatal MRI can make diagnosis and prognosis more accurate by providing additional information about tumor location, extent, appearance, degree of vascularization evolution, and metastases [11]. Unfortunately, imaging cannot differentiate between histologic types, and fetal tissue biopsy may be necessary to obtain a histological diagnosis. Antenatal diagnosis of fibrosarcoma can be obtained by an in utero ultrasound-guided needle core biopsy. However, even if the diagnosis of CF is made antenatally, the location and size of the tumor is important and should be followed closely. Tumor-associated fetal anemia may also occur, so MCA PSV should be monitored and intrauterine blood transfusion considered if necessary. Tumor location can affect fetal survival rate, especially when it compresses cervical and mediastinal structures [12]. In Case 1, since rapidly growing infiltrative mediastinal mass causing mediastinal shift and pleural effusion suggested a fetal mesenchymal tumor with a poor prognosis, no additional MRI and fetal tissue biopsy were required. The pregnancy was terminated. In Case 2, sonographic findings (multiple solid masses at the anterior wall of the thorax, the left kidney and maxillary area, polyhydramnios, scalp edema, thoracic hypoplasia, pleural and pericardial effusion) were compatible with malignant fetal tumor, and tumor-related fetal loss was observed. Both of our cases were diagnosed as fibrosarcoma at fetopsy.
Ex Utero Intrapartum Treatment (EXIT) in a rare infantile tongue fibrosarcoma and it’s management dilemma
Published in Acta Oto-Laryngologica Case Reports, 2023
Nabihah Roslle, Faizah Abdul Rahim, Norzi Gazali, Siti Sabzah Mohd Hashim, Goh Bee See
Fibrosarcoma has been defined as a malignant tumor of the fibroblasts that shows no other evidence of cellular differentiation and is capable of recurrence and metastasis. There are two types of fibrosarcoma, infantile or congenital (IF) and adult form. Infantile fibrosarcoma is a rare paediatric soft tissue sarcoma and is typically detected in children less than 1 year of age, most commonly presented as a non-tender, poorly circumscribed mass varying in size and consistency. Infantile fibrosarcoma is unique among human sarcomas because it has an excellent prognosis, very low metastatic rate and good chemosensitivity [1].