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Surgical Treatment of Fibroids
Published in Rooma Sinha, Arnold P. Advincula, Kurian Joseph, FIBROID UTERUS Surgical Challenges in Minimal Access Surgery, 2020
Ibrahim Alkatout, Liselotte Mettler
In spite of numerous theories, the etiology of fibroid formation remains unclear. While a genetic disposition must be given, as Africans have a much higher frequency of multiple myomas than Caucasians, certain up- and down-regulations in the genes of patients with or without myomas have been described. However, as yet, no clear guidelines for the prevention of fibroids are available. Hereditary leiomyomatosis and renal cell carcinoma syndrome are rare syndromes involving fibroids. Individuals with the gene that leads to both fibroids and skin leiomyomas have an increased risk of developing a rare case of kidney cell cancer (papillary renal cell carcinoma).
Hysteroscopic Myomectomy
Published in John C. Petrozza, Uterine Fibroids, 2020
Karissa Hammer, John C. Petrozza
An unfortunate reality of this procedure is that the pathology may grow back over time, especially with those that have a large fibroid burden. If patients are near menopause, this risk decreases. For patients wishing to conceive, they should be encouraged to do so within a few years from this procedure to decrease the chances of regrowth and impact on the lining [8].
Fibroids and Assisted Reproduction Technology
Published in Botros R.M.B. Rizk, Yakoub Khalaf, Mostafa A. Borahay, Fibroids and Reproduction, 2020
Subserosal myomas do not seem to affect fertility or ART outcome. A systematic review and meta-analysis including 23 studies reported that women with fibroids, irrespective of their location, had significantly lower implantation, clinical pregnancy rate (CPR), and ongoing pregnancy rate (OPR)/live birth rate (LBR) than control subjects. When the analysis was restricted to subserosal fibroids, no difference was observed for any of these outcomes. Therefore, the removal of this fibroid type does not offer any benefit [22]. Infrequently, large subserosal fibroids may impede access to the ovaries for transvaginal ovum pickup and therefore may warrant treatment.
Utilization of a nanostructured lipid carrier encapsulating pitavastatin–Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line
Published in Drug Delivery, 2023
Raed I. Felimban, Hossam H. Tayeb, Adeel G Chaudhary, Majed A. Felemban, Fuad H. Alnadwi, Sarah A. Ali, Jazia A. Alblowi, Eman ALfayez, Deena Bukhary, Mohammed Alissa, Safa H. Qahl
Oral malignancies, of which oral squamous cell carcinoma (OSCC) is the most common, are one of the most common tumors all over the world (Ferlay et al., 2015). Oral carcinoma is a major health worry, particularly in the developing world, in spite of the current techniques for cancer diagnosis and management (Rivera, 2015). OSCC is the most frequently encountered oral tumor and accounts for about 90% of oral cavity neoplasms (Casiglia & Woo, 2001). Interestingly, OSCC accounts for 4% of all cancers in males and 2% in females (Hoffman et al., 1998). Gingival neoplasms are an idiosyncratic subgroup of OSCCs, which account for approximately 10% of all OSCCs. They can simulate many benign oral lesions, particularly those of inflammatory origin, and this might result in delayed diagnoses and treatment. About 70% of gingival SCCs (GSCCs) occur in the mandible (Soo et al., 1988); they affect women more frequently than men (Barasch et al., 1994). GSCC has been clinically manifested, basically as an exophytic mass with a granulated or papillary surface or as an ulcerative lesion (Ramesh & Sadasivan, 2017). It is usually an asymptomatic, slow-growing lesion that is frequently misdiagnosed as a chronic inflammatory growth or a fibroma (Massano et al., 2006).
Lung, Liver and Skin Changes in an Infant with Positive Methamphetamine
Published in Fetal and Pediatric Pathology, 2023
Kunasilan Subramaniam, Hilma bt. Hazmi, Yong Swee Guan, Khairul Anuar bin Zainun
Post mortem examination showed an extensive erythematosus rash involving his lips, left ear, around his neck, extensor surface of his upper limbs and lower limbs, both antecubital fossa, bilateral axillae, inguinal, perineal, gluteal and lower back regions (Fig. 1). He was pale and dehydrated, but there were no visible injuries on his body. He was small for his age. His crown heel length was 61 cm (-3SD), his head circumference was 38 cm (<3rd centile), and he weighed 4650 g (<3SD). On the internal examination, the skin showed translucency due to loss of subcutaneous tissues. The chest cavities contained minimal serous fluid. His right lung weighed 41 g and left lung weighed 33 g (normal weight for lungs combined: 99.7–176 grams). The thymus has involuted. The liver was fatty (Fig. 2). Histologically, the lungs showed fibrinoid necrosis of arterial walls (Fig. 3), and pulmonary congestion, but no hemorrhage. No fibroid necrosis was apparent in other organs. The liver showed predominantly diffuse macrovesicular fatty changes (Fig. 4). Brain sections showed no edema or encephalitis. The histology section of the skin taken from the erythematosus area showed epidermal pallor, parakeratosis, and keratinocyte necrolysis. There was no inflammatory cells infiltration in the epidermis or dermis.
Long-term risk of uterine malignancies in women with uterine fibroids confirmed by myomectomy: a population-based study
Published in Journal of Obstetrics and Gynaecology, 2022
However, this study has a number of limitations. First, the claims data were used in our study. There was a possibility of miscoding. As mentioned above, the probability is very low, especially in cancer diagnostic codes. Second, data on the histopathological classifications (i.e. the malignancy subtype, such as carcinosarcoma, leiomyosarcoma, or endometrial stromal sarcoma) were not available. Approximately 3% of all uterine cancers are uterine sarcomas. In our cohort, the occurrence rate was approximately 10%, which we considered the cause of the difference in the uterine sarcoma incidence. However, it is meaningful to investigate the incidence of all uterine cancers (both endometrial cancer and uterine sarcoma corpus cancer). Third, uterine fibroid size or symptom severity were not considered while investigating uterine cancer incidence rates. Fourth, this study cannot answer the question that a fibroid can become leiomyosarcoma since fibroids were removed and not left for longitudinal observation.