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Fibrosarcoma
Published in Dongyou Liu, Tumors and Cancers, 2017
Compared with fibrosarcoma of bone, desmoplastic fibroma—the other fibrogenic bone tumor—is the bony counterpart of soft tissue fibromatosis commonly occurring in the metaphysis of long bones (56%), mandible (26%), and pelvis (14%). Macroscopically, the tumor is a white-gray, fibrous rubbery mass with variable bony spicules and cysts. Radiographically, the tumor is a lytic and honeycombed (“soap bubble”) lesion with cortical thinning, soft tissue extension, local destruction, and no metastases. Microscopically, the tumor contains mature, bland fibroblasts separated by abundant collagen with thin-walled, dilated vascular channels, infiltration into soft tissue, and the absence of necrosis, pleomorphism, atypia, and mitotic activity. Cytogenetically, the tumor is trisomy 8 and 20.
Bone and Soft Tissue Tumors
Published in Harry Griffiths, Musculoskeletal Radiology, 2008
There is a wide zone of demarcation. Approximately 10% of such cases present with a pathological fracture. Treatment is excision with clear margins and bone grafting, although 25% recur. Desmoplastic fibroma has a complicated differential diagnosis because of its aggressive appearance, and the differential diagnosis ranges from aneurysmal bone cyst, giant cell tumor, and fibrous dysplasia to more aggressive cortical lesions.
An ultrastructural pathologist’s views on fibroblasts, modified smooth muscle cells, wound healing, stenosing arteriopathies, Kawasaki disease, Dupuytren’s contracture, and the stroma of carcinomas
Published in Ultrastructural Pathology, 2020
TEM will be required to decipher the cellular components of the different phases of superficial and musculoaponeurotic fibromatoses, which include palmar, plantar, and penile fibromatosis and knuckle pads. Likewise, it is needed to ascertain the roles of fibroblasts and mSMCs in desmoid tumors, infantile fibromatosis, and desmoplastic fibroma of bone, as well as a long list of soft tissue proliferations, such as nodular and proliferative fasciitis.