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Paper 4
Published in Amanda Rabone, Benedict Thomson, Nicky Dineen, Vincent Helyar, Aidan Shaw, The Final FRCR, 2020
Amanda Rabone, Benedict Thomson, Nicky Dineen, Vincent Helyar, Aidan Shaw
A female patient is discussed at the cancer of unknown primary multidisciplinary team meeting. An MRI lumbar spine incidentally detected multiple liver lesions and several paraaortic lymph nodes measuring up to 15 mm in short axis. A malignant looking gastric lesion was subsequently identified on endoscopy.
Summary of Experience in Radiation Litigation
Published in Kenneth L. Miller, Handbook of Management of Radiation Protection Programs, 2020
On October 25, he obtained an X-ray for a complaint for backache noting an injury while moving furniture. On November 11, he reported a back strain that occurred in the alleged work incident on October 15, 1979 and was seen at the local hospital. Over the next 2 months he became ill and lost weight. On January 11, 1980, a bone marrow aspirate was obtained and a diagnosis of acute myelogenous leukemia was made. He was transferred to Hershey Medical Center. There, a diagnosis of metastatic cancer of unknown primary origin was made with metastasis to bone and liver. He did improve with chemotherapy and returned to work temporarily but the cancer progressed. He died on July 21, 1982.
Metastasis
Published in John Melford, Pocket Guide to Cancer, 2017
Once a cancer spreads to other locations, it may be difficult to determine its site of origin. When this happens the growth is referred to as a cancer of unknown primary. Up to 5% of metastatic cancers belong to this category.
Predicting response to radiotherapy of head and neck squamous cell carcinoma using radiomics from cone-beam CT images
Published in Acta Oncologica, 2022
S. Sellami, V. Bourbonne, M. Hatt, F. Tixier, D. Bouzid, F. Lucia, O. Pradier, G. Goasduff, D. Visvikis, U. Schick
Patients with stage III–IV HNSCC following the 8th TNM classification treated with curative intent with definitive RT guided by weekly CBCTs, with or without chemotherapy (depending on age, performance status as well as comorbidities) between January 2014 and May 2017 were considered in this retrospective study. Among them, those with at least four CBCTs during treatment, including CBCT at week 1 were included. Patients who benefited from surgery of the primary tumor or those treated with palliative intent were excluded, as were patients with nasopharyngeal carcinoma, thyroid and salivary glands tumors or a different histology (melanoma and lymphoma). Patients with a cancer of unknown primary origin were also excluded. Patients who benefited from a neck dissection without surgical treatment on their primary tumor were considered.
Mental Disorders and Suicide Risk among Cancer Patients: A Nationwide Cohort Study
Published in Archives of Suicide Research, 2022
Jae Woo Choi, Eun-Cheol Park, Tae Hyun Kim, Euna Han
Data obtained at the time of cancer diagnosis (sex, age, diagnosis year, Charlson comorbidity index, residential area, household income, disability, insurance type, and subtype of cancer) were used as potential confounding factors. The cancer patients were divided into young (20–39 years), middle-aged (40–64 years), and older adults (≥65 years). This study measured the Charlson comorbidity index through screening the year before the index date of study participant’s claims data. The index date was defined as first diagnosis date of cancer in this study. Household income was categorized into high income (81th–100th percentile), middle income (41th–80th percentile), and low income (below the 40th percentile). We classified residential area as (1) metropolitan (capital), (2) urban (local government where >1 million people live), and (3) rural (elsewhere). The insurance type was divided by the National Health Insurance or Medical Aid, which are public medical assistance programs for low income group. Subtypes of cancer in this study were bladder, breast, cancer of unknown primary origin, central nervous system, colorectal, cervical, Hodgkin’s lymphoma, head and neck, kidney and unspecified urinary organs, liver, leukemia, lung, mesothelioma, melanoma, non‐Hodgkin’s lymphoma, multiple myeloma, esophageal, other malignant neoplasms, ovary, pancreatic, prostate, sarcoma, stomach, testicular, and uterine.
The diagnostic challenges of patients with carcinoma of unknown primary
Published in Expert Review of Anticancer Therapy, 2020
Cancer of unknown primary (CUP) usually refers to a clinical entity that encloses a heterogeneous group of metastatic tumors without an identifiable primary after a complete diagnostic work-up [1]. This definition of CUP was initially inconsistent as some experts mandated a histologically proven biopsy and some others based their diagnosis on clinical findings without histologic confirmation [2,3]. The latter approach was quickly abandoned as the clinical perspective could not differentiate benign and malignant lesions. Moreover, the constellation of malignant lesions identified as CUP included epithelial and undifferentiated tumors only and excludes lymphomas and sarcomas, which eventually required a histologically proven cancer [1].