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Hyperthermia Treatment of Bladder Tumors
Published in Leopold J. Anghileri, Jacques Robert, Hyperthermia in Cancer Treatment, 2019
The effect of heat on normal and neoplastic bladder tissue can readily be evaluated in human material by endoscopic procedures. Some investigators studied bladder mucosa by scanning and transmission electron microscopy in patients with superficial bladder cancer who had undergone hyperthermic irrigation. A remarkable capacity for normal human urothelium, even in elderly subjects, to recover from an extended course of hyperthermia used to treat recurrent tumor was shown by Jacob et al.16 Moriyama et al.17 reported the effect of hyperthermia with bleomycin on superficial bladder cancer. The treatment induced sloughing of the outermost tumor cells; an increase in blebs; and a decrease in cytoplasmic processes, as well as cellular degeneration of deeply located tumor cells. Although less severe, nontumorous mucosa showed similar changes. Microvilli also appeared on the superficial cells of nontumorous mucosa 1 week after treatment. These investigators suggested that the treatment was effective but not specific to bladder tumor in the early phase.
Urinary Bladder Microcirculation
Published in John H. Barker, Gary L. Anderson, Michael D. Menger, Clinically Applied Microcirculation Research, 2019
Dale A. Schuschke, James I. Harty
Papillary transitional cell carcinoma is the most common type of bladder tumor. These tumors are characterized by an increase in the number of cells in the mucosal layer, followed by the formation of epithelial buds that protrude into the lumen of the bladder. These buds carry with them a stalk that contains supporting connective tissue and blood vessels. These papillary tumors can outgrow their blood supply and result in hematuria.
Urethral Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Unfavorable prognostic factors for urethral cancer include older age (>65 years), larger tumor size, later-stage or higher grade tumor, nodal involvement, lympho-vascular permeation, peri-neural involvement, metastasis, invasion of the prostate gland by prostatic urethral carcinoma, and presence of concomitant urinary bladder tumor.
Phyllodes Tumor of the Bladder in a 2-Year-Old Boy – An Exceptional Finding
Published in Fetal and Pediatric Pathology, 2023
Taycir Cheikhrouhou, Mahdi Ben Dhaou, Slim Charfi, Manar Hbaieb, Mohamed Zouari, Hayet Zitouni, Tahya Sellami Boudawara, Riadh Mhiri
To date, only one case of a human bladder phyllodes tumor has been described, which was in a 54-year-old man [7]. Phyllodes tumors have previously been reported to be mostly found in female breast tissue, followed by the prostate [1,2,5]. Several reports of phyllodes tumors of the prostate and seminal vesicle, as well as one report of a phyllodes tumor of the verumentanum, have been published [8]. Tchrakian et al. [7] proposed that phyllodes tumor of the bladder could be a cause of recurring hematuria. It is critical to distinguish from other medical conditions that may mimic bladder tumor, as hematuria may be undervalued, particularly in younger children. The child described here had urinary infection associated with significant difficulty urinating and was initially misdiagnosed as having a urinary congenital malformation.
Survival analysis of small cell carcinomas of the genitourinary system
Published in Baylor University Medical Center Proceedings, 2023
Bohdan Baralo, Michael Schneider, Ihor Baralo
We reviewed multiple available database studies and retrospective analyses of SCCB. These studies included 20 to 409 patients and reported the most common age of onset in the 60s to 70s and a male predominance. Better survival among all studies was associated with younger age, lesser extent of the tumor, absence of lymph node involvement, and absence of metastasis. OS ranged from to 10 to 15.7 months, which is consistent with the 11-month OS seen in our study. Survival improved with the administration of any treatment, as reported in our study. Most studies that assessed a combination of chemotherapy with surgery (cystectomy or transurethral resection of bladder tumor), radiotherapy, or both reported better prognosis than with chemotherapy alone.5,8,18–26
CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation
Published in OncoImmunology, 2021
Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel
Tumors were harvested for flow cytometry after mice were sacrificed via cervical dislocation and induction of deep isoflurane anesthesia. Bladder tumor dissection was as previously described.20 Subcutaneous and peritoneal B16 tumors were dissected and placed in a 6-well plate filled with serum-free RPMI-1640 and manually dissociated with the back of a syringe. Cells were incubated for 45–60 min in 3 mL serum-free RPMI-1640 with 0.25 mg/mL DNAse I and 1.65 mg/mL collagenase Type IV (both Sigma Aldrich; St. Louis, MO) and passed through a 70 µm filter to generate single-cell suspensions. 3–5 × 106 cells were then transferred to 96-well plates and samples with <5 × 106 cells from the same group were pooled to ensure uniform cell counts for all samples.