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Tumors of the Nervous System
Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020
Anaplastic oligodendroglioma is predominantly a tumor of adulthood with a peak incidence between the fourth and the sixth decade of life. Under the 2016 WHO classification of brain tumors, definitive diagnosis of oligodendroglioma requires presence of both an IDH mutation and 1p/19q codeletion. Diagnosis of anaplastic oligoastrocytoma should be avoided when possible, but is reserved for cases where molecular genetic testing is not available or inconclusive, and tumor cells have both oligodendrocytic and astrocytic features.
Oligodendroglioma
Published in Dongyou Liu, Tumors and Cancers, 2017
Histopathologically, oligodendroglioma (Grade II) contains uniform cells with round central nuclei, fine chromatin surrounded by a clear halo (or perinuclear halo, which is unstained cytoplasm resulting from an artifact of processing), delicate branching capillaries, and an absence of high-grade features. The combination of the round nuclei and perinuclear haloes results in a “fried egg” appearance of individual cells and in a honeycomb architectural pattern of groups of evenly spaced cells. Anaplastic oligodendroglioma (Grade III) typically shows focal or diffuse histological features of malignancy, with different degrees of malignant degeneration in the same lesion. Oligodendroglioma tends to calcify (which helps in radiological and histological diagnosis) and may form microcysts [6].
Secondary cerebellopontine angle oligodendroglioma after cranial irradiation: a case report and literature review
Published in International Journal of Neuroscience, 2023
Zhifei Guo, Dekun Li, Yongsheng Xie, Jin Qian, Bing Zhao
Oligodendroglioma is a neuroepithelial tumor that can be divided into oligodendroglioma (grade II) and anaplastic oligodendroglioma (grade III) according to WHO classification [9]. It often occurs in the subcortical white matter and extends to the cortex. The clinical course and prognosis of oligodendroglioma (grade II) are better than those of other gliomas. Grade III anaplastic oligodendrogliomas are more malignant tumors, which indicates a poor prognosis [10]. In our case, the pathological diagnosis was a grade II tumor. Immunohistochemically, CD34, Olig2, and synaptophysin were positive, Ki67 was 15%, and the prognosis was relatively good. However, infratentorial oligodendrogliomas may be more malignant than supratentorial oligodendrogliomas [5], tumor was not completely removed, and the recurrence time may be short, which all affect clinical course and prognosis. Further follow-up is needed.
Multicentric high grade oligodendroglioma: a rare entity
Published in British Journal of Neurosurgery, 2019
Atul Vats, Amit Amit, Paresh Doshi
Oligodendrogliomas are intrinsic brain tumour which are usually calcified solitary tumours made up of predominantly oligodendrocytes and are usually low grade gliomas (WHO Grade 2). Oligodendroglioma is commonly located in the frontal lobe. When the tumors are of mixed cell origin and contain both astrocytic and oligodendrocytic components, the astrocytic component often progresses and degenerates into anaplastic astrocytoma. This phenomena occurs in about half of oligodendrogliomas. Anaplastic oligodendroglioma (WHO grade III) has high-grade features, such as increased mitotic activity, microvascular proliferation, or necrosis. Multicentric oligodendroglioma is an extremely rare entity. Although a solitary case of multicentric low grade oligodendroglioma has been reported,1 we could not find any reports on high grade multifocal oligodendroglioma on literature search.
Incidence trends of adult malignant brain tumors in Finland, 1990–2016
Published in Acta Oncologica, 2019
Tuomas Natukka, Jani Raitanen, Hannu Haapasalo, Anssi Auvinen
In analyses of the incidence trends of adult malignant gliomas in Finland during 1990–2016, we found no increase for gliomas overall. Also, there was no difference in incidence trends between the genders. Incidence rates in the oldest age group (80+ years) increased throughout the earlier study period (1990–2006), while younger age groups showed no such increase. Incidence of glioblastoma increased slightly throughout the study period, while unspecified tumors of the brain showed a decreasing incidence trend. During 1990–2006, significant increases were observed for anaplastic oligodendroglioma, oligoastrocytoma and unspecified malignant glioma, whereas incidence of astrocytoma decreased. In addition, incidence of anaplastic astrocytoma increased in 2007–2016. Incidence rates for tumors in the frontal lobe, brainstem and unspecified location increased throughout the earlier study period. In contrast, tumor incidence decreased in the parietal lobes, cerebrum and ventricles.