China
Africa
Explore chapters and articles related to this topic
Histopathological aspects of peritoneal malignancy
Published in Tom Cecil, John Bunni, Akash Mehta, A Practical Guide to Peritoneal Malignancy, 2019
Babatunde Rowaiye, Norman Carr
Macroscopically, the cysts are filled with watery or gelatinous fluid and have thin walls. Occasionally, cysts become detached from the peritoneum and become free-floating within the abdominal cavity [48]. Histologically, cuboidal or flattened mesothelial cells line thin fibrous walls (Figure 12.12). Areas resembling adenomatoid tumour (a benign mesothelial neoplasm most often found in the genitourinary tract) are common, and some cases also show areas of WDPM. It has been suggested that multicystic mesothelioma, well-differentiated papillary mesothelioma and adenomatoid tumour are pathogenetically linked [47].
Uterine transplantation and lessons from transplant surgery
Published in J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, An Atlas of Gynecologic Oncology, 2018
Giuseppe Del Priore, Benjamin P. Jones, Srdjan Saso, J. Richard Smith
Many lessons can be learned from various aspects of transplant surgery that can be extrapolated to a whole range of medical and surgical specialties to improve clinician knowledge and experience. Advances in our own research in uterine transplantation has aided the development of novel surgical techniques, including the first case of a fertility-sparing procedure for the management of a recurrent adenomatoid tumor (Sieunarine et al. 2005). The patient, who presented with severe menorrhagia and dysmenorrhea, had previously undergone three transcervical resections of the tumor over a 12-month period, the last of which utilized ultrasound guidance and laparoscopic visualization of the uterus. She also failed to respond to medical treatment measures, including GnRH analog administration, and was further deemed unsuitable for vascular embolization. A Strassman procedure was subsequently performed, with successful removal of the adenomatoid tumor. This involved careful dissection of the ureters and pelvic vasculature, selective temporary ligation of uterine arteries, and hemisection of the uterus, followed by excision of the tumor. Frozen sections were undertaken to ensure clear tumor margins before the two uterine halves were sutured back together. Two and a half years on there is no evidence of recurrence. Similar techniques have been utilised in the successful management of placental site trophoblastic tumor (PSTT), described further in Chapter 25, and arteriovenous malformation, using temporary ligation of the uterine and ovarian vessels.
Fallopian Tube, Broad Ligament, and Peritoneal Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Tumors of the peritoneum comprise (1) peritoneal tumors, (2) mesothelial tumors (diffuse malignant mesothelioma, well-differentiated papillary mesothelioma, multicystic mesothelioma, adenomatoid tumor), (3) smooth muscle tumor (leiomyomatosis peritonealis disseminate), (4) tumor of uncertain origin (desmoplastic small round cell tumor), and (5) epithelial tumors (primary peritoneal serous adenocarcinoma, primary peritoneal borderline tumor) [1].
Selection of abstracts from Baylor Scott & White Health Central Texas Scholars Day
Published in Baylor University Medical Center Proceedings, 2021
Angela D. Rutherford, Wendy Hegefeld, William Culp, Patrick Lowry, Hania Janek, Shekhar Ghamande, Megan Newman, Austin Metting, J. Scott Thomas, V. Maxanne Flores, Niraj Vora, Christian Cable
Ovarian hilus cells are found in the ovarian hilum. Of the few reported cases of hilus cells occurring outside the ovarian hilum, all have been incidental findings associated with other gynecological abnormalities. The objective was to describe the clinicopathologic characteristics of patients with hilus cell heterotopia (HCH) at our institution between 2003 and 2020. Eight cases were identified. Patient age ranged from 43 to 70 years. Three patients had postmenopausal bleeding, two had pelvic pain, two had asymptomatic ovarian cysts, two had elevated preoperative CA-125, one had uterine prolapse, and one had Turner syndrome. HCH was an incidental finding in all cases. One or more other abnormalities occurred in seven of eight cases: adenomyosis (four cases); leiomyomata, endometrial endometrioid adenocarcinoma, and ovarian serous cystadenomas (three cases each); and ovarian fibroma, ovarian serous borderline tumor, Brenner tumor, and adenomatoid tumor (one case each). All patients were disease free throughout follow-up. HCH is a rare incidental finding sometimes present in gynecologic surgical pathology specimens, usually the fallopian tube. This study showed that other gynecological abnormalities were identified alongside HCH in most cases. Additional study is needed to determine whether HCH can have clinically significant hormonal effects or display neoplastic potential.
Targeting Bone Metastases Signaling Pathway Using Moringa oleifera Seed Nutri-miRs: A Cross Kingdom Approach
Published in Nutrition and Cancer, 2022
Kinjal Bhadresha, Maulikkumar Patel, Jpan Brahmbhatt, Nayan Jain, Rakesh Rawal
On showing the gene-disease interaction analysis of identified human target genes, their association with different diseases was revealed. Some genes such as TAF1 regulated by the miR159, miR396a, miR1515 family were identified to play a vital role in dystonia and torsion (23). Respectively, the miR408, miR6478, miR159b/c, and miR394b modulated genes TIMP2 and TIMP3 verified extensive significance in diseases such as gallbladder cancer, lipodermatosclerosis, juvenile pilocytic astrocytoma and fundus dystrophy (24, 25). The SSBP1 gene modulated by miR399a/d, this gene involvement in autistic disorder (26). Furthermore, some genes such as ALAD, PKP1, CBFB, FGF2, FGF1, and CYR61 were found to have an important role in porphyria, acute hepatic, tyrosinemia, ectodermal dysplasia/skin fragility syndrome, acute myeloid leukemia, cleidocranial dysplasia, kaposi sarcoma, chronic myocardial ischemia, sclerosteosis, vitreoretinopathy, wilms tumor susceptibility-5 and prostate cancer (27–32). Moreover, certain genes controlled by miR398a were originating to be related to breast cancer, ovarian cancer, and osteoporosis (33). In addition, few genes such as USP34 and SEZ6L were known that has not been earlier related with any of the diseases; though, these genes were originated to have a noteworthy function in regulating vigorous biological and molecular processes like translocation and splicing regulation for cellular survival (34). Similarly, few genes such as SATB2, NOV, CALB2, MDM2, LYN, AKT1, TOP1, and RRM2 have a significant role in various cancers such as periampullary adenocarcinoma, wilms tumor susceptibility-5, adenomatoid tumor, adenofibroma, aertoli-leydig cell tumor, dedifferentiated liposarcoma, sarcoma, leukemia, chronic myeloid, ovarian cancer, breast cancer, lung cancer, pancreatic cancer, hepatocellular carcinoma (35–41). Furthermore, some of the identified human targeted genes modulated miRNA families such as miR5559, miR159, miR156, miR396, miR1310, miR162, miR172, miR169d, miR398a, miR403, miR395, miR3711, miR397a, miR157a/d, miR168a/c/d, miR7751, miR530, a significance of gene was confirmed in diseases like autosomal dominant, microcephaly, fanconi anemia, dicarboxylic aminoaciduria, schizoaffective disorder, epidermolysis bullosa, commensal bacterial infectious disease, coronary heart disease, arthritis, lymph node disease, gapo syndrome, hemangioma, capillary infantile, diphtheria, bladder disease, urinary tract obstruction, cardiomyopathy, keratoderma, leukoencephalopathy, autosomal recessive, membranous nephropathy, thrombocythemia, and vertebral artery occlusion (42–48). In addition, we also found that some of the genes have a vital role in bone cancer and bone diseases such as CXCL12, CDH11, EGF, COL1A2, and COL6A3, a noteworthy gene were role in osteosarcoma, osteogenesis Imperfecta, and adamantinoma of long bones (49–51) (Table 3).