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Carcinoma of the Vagina and Vulva
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Sadaf Ghaem-Maghami, Kostas Lathouras
Usually an adenocarcinoma, this tumor may be squamous, transitional cell type, or even mixed squamous and adenocarcinoma. It has often spread widely to pelvic and groin nodes before the diagnosis is made. It must be distinguished from adenoid cystic carcinoma, which is similar to the tumor found in salivary glands and which seldom gives rise to metastatic disease. The treatment is surgery, but because of its deep origin, part of the vagina, levatores ani, and the ischio-rectal fat must be removed.
The salivary glands
Published in Neeraj Sethi, R. James A. England, Neil de Zoysa, Head, Neck and Thyroid Surgery, 2020
Basal cell adenoma is characteristically encapsulated. It has an intact basement membrane, which differentiates it from pleomorphic adenoma. It can be difficult to distinguish from solid adenoid cystic carcinoma on biopsy [19].
Breast
Published in Joseph Kovi, Hung Dinh Duong, Frozen Section In Surgical Pathology: An Atlas, 2019
Joseph Kovi, M.D. Hung Dinh Duong
In contrast to the ubiquitous invasive duct carcinoma adenoid cystic carcinoma has a favorable prognosis. Lymph node involvement is virtually unheard of.53,88 Axillary lymph node metastasis occurs in 40.6% to 67% of patients with invasive duct carcinoma.47,83 Among the 21 patients with adenoid cystic carcinoma of the breast reported by Cavanzo and Taylor,88 none died of the disease. Simple mastectomy is the recommended treatment.
A single-institution review of lacrimal gland biopsies between 1962 and 2017
Published in Orbit, 2023
Catherine J. Choi, Ann Q. Tran, Apostolos G. Anagnostopoulos, Henry W. Zhou, David T. Tse, Sander R. Dubovy
The most common surgical indications listed on the pathology requisition forms included enlarged lacrimal gland with discomfort/pain (110, 27%), rule out lymphoma (100, 25%), rule out pseudotumor (94, 23%), rule out other malignancy (60, 15%), and other (35, 9%). Based on these pre-operative indications listed, 42% of final diagnoses were consistent with the preliminary diagnoses. Of these, the largest groups were lymphoma (55), pseudotumor or NSOI (53), pleomorphic adenoma (13), adenoid cystic carcinoma (8), and metastasis (6). Thirty-seven of the lymphoma cases had evidence of lacrimal gland enlargement on imaging, 10 of which also had concurrent extraocular muscle enlargement. Clinical presentations of these lymphoma patients were largely described as painless eyelid or lacrimal gland swelling with or without proptosis. Thirty-six of the pseudotumor or NSOI patients had evidence of lacrimal gland enlargement on imaging, 16 of which also had concurrent extraocular muscle enlargement. All cases of pleomorphic adenoma presented with a slowly enlarging painless lacrimal gland mass without any involvement of extraocular muscles. Five of the patients with adenoid cystic carcinoma were recurrences with a prior history, and all six cases with metastasis had known primary malignancies at the time of presentation. Exenteration was performed for 8 cases of adenoid cystic carcinoma, 1 carcinoma ex-pleomorphic adenoma, 1 squamous cell carcinoma, and 1 metastatic breast carcinoma.
Adenoid cystic carcinoma of the parotid gland: a first case report on 11C-methionine PET/CT detection of histologically confirmed pulmonary metastases
Published in Acta Oncologica, 2022
Silvia Taralli, Antonella Martino, Alessandra Cancellieri, Lucio Calandriello, Filippo Lococo, Carmelo Caldarella
Adenoid cystic carcinoma (ACC) is a rare head-and-neck malignancy, with a yearly incidence of 3–4.5 cases per million, most commonly observed in middle age women and involving salivary glands. Despite an apparently local indolent course, ACC has an aggressive long-term behavior, presenting with local or distant recurrence even several years after optimal primary tumor treatment, and with a rather poor prognosis (15-years overall survival rate <25%) [1–3]. Distant metastases are observed in more than 50% of cases, even up to 10–20 years after the first diagnosis, being lung the most common site of metastatic involvement. 11C-methionine (11C-MET) positron emission tomography/computed tomography (PET/CT) is considered an effective imaging tool for assessing recurrent ACC, with tracer uptake reflecting increased amino acid metabolism associated with tumor growth [4,5]. However, 11C-MET PET/CT detection of histologically confirmed ACC pulmonary metastases has never been reported before.
The role of frozen section biopsy for submandibular gland tumors
Published in Acta Oto-Laryngologica, 2021
Masahiro Suzuki, Yuta Nakaegawa, Tomotaka Kawase, Masakazu Ikeda, Shigeyuki Murono
Among the 42 patients who had undergone FNAC and FSB, 37, four and one were diagnosed as having benign, indeterminate and malignant tumors, respectively, by FNAC. Of the 37 benign cases, FNAC revealed suspected pleomorphic adenoma (PA) in 24 cases, and could not histologically identify 13 cases. The malignant case detected was suspected to be adenoid cystic carcinoma. Using FSB, 36, three and three cases were diagnosed as benign, indeterminate, and malignant, respectively. Of the 36 benign cases, FSB revealed suspected PA in 34 cases and suspected basal cell adenoma in one case, and could not histologically identify one case. Of the three malignant cases, FSB revealed suspected solitary fibrous tumor in one case, adenocarcinoma in one case, and adenoid cystic carcinoma in one case. The final histological diagnoses showed that 38 cases were benign and four were malignant. All 38 histologically benign cases were PA. The histological tumor types of the four malignant cases included three cases of adenoid cystic carcinoma and one case of carcinoma ex PA (Table 1).