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The Future Is Not What It Used to Be
Published in Tom Lawry, Hacking Healthcare, 2022
Steady advancements are being made in 3D bioprinting. This includes progress in the ability to bioprint bones, skin, blood vessels, cartilage, and even organs. While there is still much progress to be made before most of these practices are adapted into human medicine, this trend holds the promise of collecting data as well as noninvasive ways to see how the human body interacts with certain substances, which could lead to more personalized medicine for patients and fewer side effects.
From Conventional Approaches to Sol-gel Chemistry and Strategies for the Design of 3D Additive Manufactured Scaffolds for Craniofacial Tissue Engineering
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
A. Gloria, T. Russo, M. Martorelli, De Santis R.
However, in this context 3D cell printing technology would also be an interesting approach enabling researchers to suspend and position cells embedded in materials such as hydrogels (Tao et al. 2019). 3D bioprinting could allow in obtaining specific mechanical properties, cell interactions and desired distribution of growth factors. The possibility of printing blood capillaries has been already reported and cell printing for craniofacial tissue regeneration would seem feasible, even if many studies are still ongoing (Tao et al. 2019).
Tissue Engineering and Cell Therapies for Neurogenic Bladder Augmentation and Urinary Continence Restoration
Published in Jacques Corcos, Gilles Karsenty, Thomas Kessler, David Ginsberg, Essentials of the Adult Neurogenic Bladder, 2020
The main approaches for 3D bioprinting are inkjet printing, stereolithography, and extrusion printing. Inkjet bioprinters can deliver biomaterials and cells in controlled volumes like ink in a cartridge delivers droplets to paper to create documents.
3D bioprinting for organ and organoid models and disease modeling
Published in Expert Opinion on Drug Discovery, 2023
Amanda C. Juraski, Sonali Sharma, Sydney Sparanese, Victor A. da Silva, Julie Wong, Zachary Laksman, Ryan Flannigan, Leili Rohani, Stephanie M. Willerth
The advancement of 3D bioprinting enables the fabrication of in vitro 3D tissue models with specific extracellular features and cell organization. When compared to 2D cell cultures or animal models, 3D bioprinted organ models can better replicate the disposition of natural tissue, cell-cell interactions, and cell-extracellular matrix (ECM) interactions. For example, these models can be obtained from 3D constructs printed with human embryonic stem cells or human induced pluripotent stem cells (hiPSCs) and later differentiated into the cell types found in the target tissue [12]. The presence of heterogenous cell profiles on and cell-cell communication within the final construct allows the reproduction of the complex physiological environment, which makes 3D bioprinted models especially relevant for clinical applications such as drug screening [13] (Figure 2).
Future prospects in 3-dimensional (3D) technology and Mohs micrographic surgery
Published in Journal of Dermatological Treatment, 2022
Stephanie Ishack, Amor Khachemoune
The advancement of three-dimensional (3D) bioprinting has allowed for innovative and revolutionary changes within the field of regenerative medicine. Three-dimensional (3D) skin printing is a transformative technology used to fabricate biomimetic scaffold architectures which mimic human skin. 3D bioprinting uses a robotic stage and computer-aided design (CAD) systems to design layered tissue medical devices made from biomaterials. There are three major types of biological printing: inkjet-based bioprinting, laser-assisted bioprinting (LAB), and pressure-assisted bioprinting (1). Most of the applications of 3D printing in surgery focus on these three categories: surgical 3D models, surgical guides, and implants. Moreover, 3D printing software can be used to extract digital data from patients through the use of computed tomography, magnetic resonance imaging or computational laser scanning. These tools allow for custom-made and personalized skin constructs that can be used for scaffold implantation during Mohs micrographic surgery (MMS).
Current advances in cell therapeutics: a biomacromolecules application perspective
Published in Expert Opinion on Drug Delivery, 2022
Samson A. Adeyemi, Yahya E. Choonara
Interestingly, several clinical trials in which cellulose sulphate is used as the biomacromolecule for encapsulation, the microcapsules showed viable anti-tumour effects and exhibited superior biocompatibility with no adverse reactions such as a host immune response. Further research is needed to understand the role of various biomacromolecules in mounting an immune response. With the significant advances made in complementary scientific domains such as nanotechnology and 3D-bioprinting, the future of smart implantable cell therapeutics is closer than expected. 3D-bioprinting is a rapidly growing technology that holds great potential for the design and fabrication of functional tissues and organs. Using this approach, the patient<apos;>s cells can be utilized to design, engineer and produce constructs to replace diseased tissues and organs.