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Alginate and Hydrogel Applications for Wound Dressing
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Dina Fransiska, Ellya Sinurat, Fera Roswita Dewi, Hari Eko Irianto
Wound healing is a complex and ongoing process influenced by various factors, and it requires the right environment to recover quickly. Various wound dressings, such as fiber, sponge, hydrogel, foam, hydrocolloid, and others are used for wound treatment. Hydrogels are commonly employed in the biomedical industry because they may give mechanical support and a wet environment for wounds (Zhang & Zhao, 2020).
Application of Viral Nanomaterials in Medicine
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Sudhakar Pola, Dhanalakshmi Padi
Hydrogels have many biomedical applications, such as drug delivery, cell culture, and tissue reconstruction during wound healing. The formation of biofilms increased the surface biocompatibility and cellular proliferation effectively; also, hydrogels have the ability to bind the negatively charged particles that are applied to the tissue engineering (Figure 8.1).
Fenugreek
Published in Dilip Ghosh, Prasad Thakurdesai, Fenugreek, 2022
Ujjwala Kandekar, Sunil Ramdasi, Prasad Thakurdesai
Because of the high water-holding capacity, fenugreek gum could be effectively used as antimicrobial packing material for hydrogel formulations for wound-healing effects. Hydrogels are hydrophilic three-dimensional structures having the ability to hold a large amount of water (Ahmed 2015). Composite hydrogel from fenugreek gum and cellulose was reported as porous, thermally stable with good water retention capability, with sustained effects that are desirable for good wound-healing formulation (Deng et al. 2020). Furthermore, the fenugreek gum hydrogel formulation (20% and 40%) prevented loss of blood and better wound-healing rate with excellent biocompatibility during 10-day application to wounds in mice (Deng et al. 2020). Researchers suggested the fenugreek gum hydrogel’s property of increased expression of factors such as vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β) (Cheng et al. 2018; Miscianinov et al. 2018) might be responsible for promoting neovascularization, tissue regeneration, and stimulated collagen synthesis and accelerated wound healing (Deng et al. 2020).
Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye
Published in Drug Delivery, 2023
Dong Wei, Ning Pu, Si-Yu Li, Yan-Ge Wang, Ye Tao
Hydrogels have been used as safe, comfortable, and effective probes for iontophoresis in ophthalmological practice (Gratieri et al., 2017; Jiang et al., 2021). Hydrogels are made of hydrophilic polymer with perfect water solubility. Previously, hydrogels are used for producing contact lenses and for controlled transdermal drug delivery. During iontophoresis, drug saturated hydrogels would facilitate drug handling, minimize tissue hydration, and modulating drug release kinetics (Guigui et al., 2020). Hydrogel probe can deliver a substantial amount of loaded antibiotics to the posterior segment of the eyeball. Thus far, several recent studies have used hydrogel probes to deliver therapeutic doses of antibiotics to treat ocular infections and inflammatory conditions (Eljarrat-Binstock et al., 2004; Chen & Kalia, 2018).
Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment
Published in Drug Delivery, 2022
Duy Toan Pham, Nguyen Thi Phuong Thao, Bui Thi Phuong Thuy, Van De Tran, Thanh Q. C. Nguyen, Ngoc Nha Thao Nguyen
To this end, hydrogels, crosslinked-network structures of water-soluble polymers possessing similar physiochemical properties to the extracellular matrix, prove their advantages. Hydrogels are biocompatible, versatile in entrapping various therapeutic compounds, possess controlled-release property due to high porosity, and could be easily formulated utilizing mild processing conditions (Li & Mooney 2016; Lee et al. 2018; Vigata et al. 2020; Pham et al. 2021). For RA treatment, local administration of hydrogel to the inflammatory joint sites significantly sustain the drug release rate to more than 20 days and enhance its therapeutic effects compared to the free drug (Kim et al. 2011; Oliveira et al., 2020, 2020). Among numerous hydrogel biomaterials, silk fibroin, commonly extracted from Bombyx mori silkworm, has gained increasingly attention due to its biocompatibility, biodegradability, versatility in chemical modification, controlled-release property, among others (Pham et al., 2019, 2020, 2021). Fibroin hydrogels have been proposed and developed for various biomedical applications (Oliveira et al., 2020; Zheng & Zuo 2021; Ziadlou et al. 2021). Nevertheless, although proving much potentials for RA treatment, reports on fibroin-based hydrogels for this purpose are limited. To the best of our knowledge, only one article has been published on this issue (Oliveira et al., 2020). Therefore, it is important to explore this research gap.
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system
Published in Drug Delivery, 2022
Cixin Huang, Xia Qi, Huilin Chen, Chao Wei, Xiaolin Qi, Hongwei Wang, Hua Gao
In the past decade, hydrogel-based biomaterials attracted significant attention in biomedical science and industrial applications due to their tunable physical, mechanical, and biological characteristics (Luo et al., 2019; Zhu et al., 2020; Clasky et al., 2021). Hydrogels are a form of three-dimensional networks of physically or chemically crosslinked polymers. Gelatin has been extensively been adopted to fabricate hydrogels for biomedical applications such as regenerative medicine (Griffin et al., 2021; Tong et al., 2021), tissue engineering (Park et al., 2020), and drug delivery (Luo et al., 2019; Dou et al., 2020) because of their following attributes: high hydrophilicity, high degree of swelling, excellent biocompatibility, and low immune response. Among these features, the swelling property of hydrogel can to some extent increase biological compatibility; however, it can also cause the mechanical compression of tissues (Ding et al., 2021; M. Zhang et al., 2019). Moreover, low-loading amounts also impeded the wide applications of hydrogels. Thus, it was interesting for researchers to develop hydrogels with a reduced swelling property and an enhanced loading efficiency by chemical modification with functional materials.